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Association between glutathione S-transferase T1 null genotype and risk of myelodysplastic syndromes: a comprehensive meta-analysis

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Tumor Biology

Abstract

Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematologic neoplasms, and the pathophysiology of these disorders is still unclear. Previous studies investigating the association between glutathione S-transferase Tl (GSTT1) null genotype and risk of MDS reported controversial results. We performed a comprehensive meta-analysis to clarify the effect of GSTT1 null genotype on risk of MDS. The strength of the association was measured by odds ratio (OR) with 95 % confidence interval (CI). Fifteen studies were finally included, involving a total of 1,796 cases and 2,502 controls. Subgroup analysis was performed by race. Meta-analysis of all 15 studies showed that the GSTT1 null genotype was significantly associated with an increased risk of MDS (OR = 1.47, 95 % CI 1.16–1.88, P OR = 0.002; I 2 = 54.4 %). Besides, an obvious association was also observed after adjusting the heterogeneity (OR = 1.32, 95 % CI 1.13–1.54, P OR = 0.001; I 2 = 9.0 %). Subgroup analysis by race suggested that this association existed in both Caucasians (OR = 1.40, 95 % CI 1.04–1.89, P OR = 0.027) and Asians (OR = 1.68, 95 % CI 1.00–2.81, P OR = 0.049). This meta-analysis suggests the GSTT1 null genotype is significantly associated with an increased risk of MDS in both Caucasians and Asians.

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Authors and Affiliations

  1. Department of Emergency Medicine, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Minghao Fang

  2. Department of Hematology, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095# Jiefang Avenue, Wuhan, 430030, China

    Wen Zeng, Lifang Huang, Shuang Qin, Jianfeng Zhou, Hanying Sun & Fankai Meng

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  1. Minghao Fang
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  2. Wen Zeng
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Correspondence to Fankai Meng.

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Fang, M., Zeng, W., Huang, L. et al. Association between glutathione S-transferase T1 null genotype and risk of myelodysplastic syndromes: a comprehensive meta-analysis. Tumor Biol. 34, 2747–2752 (2013). https://doi.org/10.1007/s13277-013-0828-6

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  • DOI: https://doi.org/10.1007/s13277-013-0828-6

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