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Cyclin D1 G870A polymorphism and lung cancer risk: a meta-analysis

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Tumor Biology

Abstract

Many studies have investigated the association between Cyclin D1 (CCND1) G870A polymorphism and lung cancer risk, but the impact of CCND G870A polymorphism on lung cancer is unclear owing to the obvious inconsistence among those studies. This study aimed to quantify the strength of association between CCND1 G870A polymorphism and lung cancer risk. We searched the PubMed, Embase, and Wangfang databases for articles on studies relating the CCND1 G870A polymorphism to the risk of lung cancer in humans. We estimated summary odds ratios (ORs) with their confidence intervals (CIs) to assess the association. Meta-analyses of total studies showed that CCND1 G870A polymorphism was associated with lung cancer risk under three genetic models (ORA versus G = 1.13, 95 % CI 1.03–1.24; ORAA versus GG = 1.20, 95 % CI 1.07–1.35; ORAA versus AG + GG = 1.23, 95 % CI 1.02–1.50). Meta-analyses of studies with high quality showed that CCND1 G870A polymorphism was associated with lung cancer risk under two genetic models (ORA versus G = 1.08, 95 % CI 1.02–1.15; ORAA versus GG = 1.17, 95 % CI 1.04–1.32). Subgroup analyses by ethnicity and sensitivity analyses further identified the significant association above. No evidence of publication bias was observed. Meta-analyses of available data show a significant association between the CCND1 G870A polymorphism and lung cancer risk, and CCND1 G870A polymorphic variant A contributes to increased risk of lung cancer.

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Acknowledgments

We thank Fei Zhang, Xiangya Hospital of Changsha, for her statistical support.

Funding

No external funding was either sought or obtained for this study.

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Authors and Affiliations

  1. Department of Respiratory diseases, the Third Xiangya Hospital of Central South University, Changsha, 410013, China

    Jianming Liu & Shenghua Sun

  2. National Hepatobiliary and Enteric Surgery Research Center of Ministry of Health, Changsha, 410008, People’s Republic of China

    Jianming Liu, Qiande Liao & Yangde Zhang

  3. Department of Health Toxicology, School of Public Health of Central South University, Changsha, 410078, China

    Caigao Zhong & Xinmin Liu

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  1. Jianming Liu
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  2. Qiande Liao
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  6. Xinmin Liu
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Correspondence to Qiande Liao.

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Liu, J., Liao, Q., Zhang, Y. et al. Cyclin D1 G870A polymorphism and lung cancer risk: a meta-analysis. Tumor Biol. 33, 1467–1476 (2012). https://doi.org/10.1007/s13277-012-0397-0

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