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Indian Perspective on Clinical Aspects, Usage, and Guidelines of Folic Acid

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Abstract

Folic acid (pteroylmonoglutamic acid) is the stable, fully oxidized form of folate which is used in food fortification and supplements. Keen interest has been generated in folic acid due to its suggested role in prevention of various disorders. Strong evidence from clinical trials indicates preventive effect of folic acid on both occurrence and recurrence of neural tube defects. It also plays a significant role in mitigating the risk of cardiovascular disorders through homocysteine regulation. In addition, the beneficial effect of folic acid in various types of cancers, neurological disorders, conditions affecting pregnancy, and other clinical conditions has been reported in literature. Various guidelines reinforce the need for women to obtain adequate amount of folic acid either through food fortification or supplements. In India, national guidelines on the proper dose of folic acid to pregnant women are not available. Given its significant beneficial effects on health, awareness should be spread among communities on the usage and benefits of folic acid.

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References

  1. Lucock M. Is folic acid the ultimate functional food component for disease prevention? BMJ. 2004;328(7433):211–4.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  2. Crider KS, Bailey LB, Berry RJ. Folic acid food fortification-its history, effect, concerns, and future directions. Nutrients. 2011;3(3):370–84.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Lucock M. Folic acid: nutritional biochemistry, molecular biology, and role in disease processes. Mol Genet Metab. 2000;71(1–2):121–38.

    Article  PubMed  CAS  Google Scholar 

  4. Wani NA, Hamid A, Kaur J. Folate status in various pathophysiological conditions. IUBMB Life. 2008;60(12):834–42.

    Article  PubMed  Google Scholar 

  5. Chandra J. Megaloblastic anemia: back in focus. Indian J Pediatr. 2010;77(7):795–9.

    Article  PubMed  Google Scholar 

  6. Wald DS, Wald NJ, Morris JK, Law M. Folic acid, homocysteine, and cardiovascular disease: judging causality in the face of inconclusive trial evidence. BMJ. 2006;333(7578):1114–7.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  7. Wang X, Qin X, Demirtas H et al. Efficacy of folic acid supplementation in stroke prevention: a meta-analysis. Lancet. 2007;369(9576):1876–82.

    Article  PubMed  CAS  Google Scholar 

  8. Cook S, Hess OM. Homocysteine and B vitamins. Handb Exp Pharmacol. 2005;170:325–38.

    Article  PubMed  CAS  Google Scholar 

  9. Reynolds E. Vitamin B12, folic acid, and the nervous system. Lancet Neurol. 2006;5(11):949–60.

    Article  PubMed  CAS  Google Scholar 

  10. Selhub J, Bagley LC, Miller J, et al. B vitamins, homocysteine, and neurocognitive function in the elderly. Am J Clin Nutr. 2000;71:614S–20S.

    PubMed  CAS  Google Scholar 

  11. Blencowe H, Cousens S, Modell B, et al. Folic acid to reduce neonatal mortality from neural tube disorders. Int J Epidemiol. 2010;39(Suppl 1):i110–21.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Au KS, Ashley-Koch A, Northrup H. Epidemiologic and genetic aspects of spina bifida and other neural tube defects. Dev Disabil Res Rev. 2010;16(1):6–15.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Botto LD, Moore CA, Khoury MJ, et al. Nural tube defects. N Engl J Med. 1999;341:1509–19.

    Article  PubMed  CAS  Google Scholar 

  14. Williams LJ, Rasmussen SA, Flores A, et al. Decline in the prevalence of spina bifida and anencephaly by race/ethnicity. Pediatrics. 2005;116(3):580–6.

    Article  PubMed  Google Scholar 

  15. De Wals P, Tairou F, Van Allen MI, et al. Reduction in neural-tube defects after folic acid fortification in Canada. N Engl J Med. 2007;357(2):135–42.

    Article  PubMed  Google Scholar 

  16. Lumley J, Watson L, Watson M, et al. Periconceptional supplementation with folate and/or multivitamins for preventing neural tube defects. Cochrane Database Syst Rev. 2001;3:CD001056.

    PubMed  Google Scholar 

  17. Rampersaud GC, Bailey LB, Kauwell GPA. Relationship of folate to colorectal and cervical cancer. Review and recommendations for practitioners. J Am Diet Assoc. 2002;102:1273–82.

    Article  PubMed  Google Scholar 

  18. Choi S-W, Mason JB. Folate and carcinogenesis: an integrated scheme. J Nutr. 2000;130:129–32.

    PubMed  CAS  Google Scholar 

  19. WHO Guideline. Daily iron and folic acid supplementation in pregnant women. Geneva: World Health Organization; 2012.

    Google Scholar 

  20. Nutrient requirements and recommended dietary allowances for Indians. A Report of the Expert Group of the Indian Council of Medical Research; 2009.

  21. Joint SOGC-MOTHERISK Clinical Practice Guideline. Pre-conceptional vitamin/folic acid supplementation 2007: the use of folic acid in combination with a multivitamin supplement for the prevention of neural tube defects and other congenital anomalies. J Obstet Gynaecol Can. 2007;29(12):1003–26.

    Google Scholar 

  22. McNulty B, Pentieva K, Marshall B, et al. Women’s compliance with current folic acid recommendations and achievement of optimal vitamin status for preventing neural tube defects. Hum Reprod. 2011;26(6):1530–6.

    Article  PubMed  CAS  Google Scholar 

  23. Katre P, Bhat D, Lubree H, et al. Vitamin B12 and folic acid supplementation and plasma total homocysteine concentrations in pregnant Indian women with low B12 and high folate status. Asia Pac J Clin Nutr. 2010;19(3):335–43.

    PubMed  CAS  Google Scholar 

  24. Salvi VS, Damania KR. Neural tube defects in India—time for action. Lancet. 2005;366:871–2.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. OBGY, Shree Clinic, Shreya Nagar, Aurangabad, India

    Chobe Paayal (Consultant Gynecologist)

  2. Pharmacology, Flat no. 603 B-wing, Om Jai Balaji Heights, Ramdev Park, Mira Road (East), Thane, 401107, Maharashtra, India

    Uchit Ganesh (Clinical Pharmacologist)

  3. Pharmaceutical Medicine, Andheri (East), Mumbai, India

    Donde Shaantanu (Consultant)

Authors
  1. Chobe Paayal
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  2. Uchit Ganesh
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  3. Donde Shaantanu
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Correspondence to Uchit Ganesh.

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Paayal, C., Ganesh, U. & Shaantanu, D. Indian Perspective on Clinical Aspects, Usage, and Guidelines of Folic Acid. J Obstet Gynecol India 64, 328–331 (2014). https://doi.org/10.1007/s13224-014-0526-3

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  • DOI: https://doi.org/10.1007/s13224-014-0526-3

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