Skip to main content
SpringerLink
Log in

The correlation between the clinical laboratory data and the telomere length in peripheral blood leukocytes of Japanese female patients with hypertension

  • Clinical Laboratory Data, Telomere Length in Peripheral Blood Leukocytes
  • Published:
The journal of nutrition, health & aging

Abstract

Objective

This study investigated the correlation between the chronological age, telomere length in peripheral blood leukocytes and blood laboratory data of female patients with mild hypertension to identify laboratory data that reflect the biological aging of individuals.

Design

Cross-sectional population-based study.

Setting

Outpatient clinic of the Department of Cardiovascular, Respiratory, and Geriatric Medicine Kyushu University Hospital at Beppu in Japan.

Participants

Outpatients with mild hypertension treated with a low dose of amlodipine.

Measurements

The laboratory data of female patients were collected and the telomere length parameters in their peripheral blood leukocytes were determined by Southern blotting. Any correlations between the laboratory data and the telomere length parameters were assessed.

Results

The patients showed a positive correlation between the telomere length and the high density lipoprotein, albumin, creatinine, hemoglobin levels, red blood cell counts, and a negative correlation with the globulin level. The extent of subtelomeric methylation of long telomeres tended to correlate negatively with the telomeric attrition. Only the creatinine level correlated with subtelomeric methylation, but not with telomeric length.

Conclusion

HDL and the albumin/globulin ratio were potential indicators for individual somatic genomic aging. Creatinine may therefore be a useful indicator for a predisposition for telomeric attrition.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Blackburn EH Structure and function of telomeres. Nature (London). 1991;350:569–573.

    Article  CAS  Google Scholar 

  2. Zakian VA. Telomeres: beginning to understand the end. Science. 1995;270:1601–1607.

    Article  PubMed  CAS  Google Scholar 

  3. Aubert G, Lansdorp PM. Telomeres and aging. Physiol Rev. 2008;88:557–795.

    Article  PubMed  CAS  Google Scholar 

  4. Iwama H, Ohyashiki K, Ohyashiki JH, et al. Telomeric length and telomerase activity vary with age in peripheral blood cells obtained from normal individuals. Hum Genet. 1998;102:397–402.

    Article  PubMed  CAS  Google Scholar 

  5. Guan JZ, Maeda T, Sugano M, Oyama J, Higuchi Y, Makino N. Change in the telomere length distribution with age in the Japanese population. Mol Cell Biochem. 2007;304:253–260.

    Article  Google Scholar 

  6. Sidorova I, Kimurab M, Yashinc A, Aviv A. Leukocyte telomere dynamics and human hematopoietic stem cell kinetics during somatic growth. Experimental Hematology 2009;37:514–524.

    Article  Google Scholar 

  7. Okuda K, Khan MY, Skurnick J, et al. Telomere attrition of the human abdominal aorta: relationships with age and atherosclerosis. Atherosclerosis. 2000;152:391–398.

    Article  PubMed  CAS  Google Scholar 

  8. Uziel O, Singer JA, Danicek V, et al. Telomere dynamics in arteries and mononuclear cells of diabetic patients: effect of diabetes and of glycemic control. Exp Gerontol. 2007;42:971–978.

    Article  PubMed  CAS  Google Scholar 

  9. Panossian LA, Porter VR, Valenzuela HF, et al. Telomere shortening in T cells correlates with Alzheimer’s disease status. Neurobiol ageing. 2003;24:77–84.

    Article  CAS  Google Scholar 

  10. Valdes AM, Andrew T, Gardner JP, et al. Obesity, cigarette smoking, and telomere length in women. Lancet. 2005;366:662–664.

    Article  PubMed  CAS  Google Scholar 

  11. Epel ES, Blackburn EH, Lin F, et al. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci U S A. 2004;101:17312–17315.

    Article  PubMed  CAS  Google Scholar 

  12. Guan JZ, Maeda T, Sugano M, et al. A Percentage analysis of the telomere length in Parkinson’s disease patients. J Gerontol A Biol Sci Med Sci. 2008;63A:467–473.

    CAS  Google Scholar 

  13. Guan JZ, Maeda T, Sugano M, et al. An analysis of telomere length in sarcoidosis. J Gerontol A Biol Sci Med Sci. 2007;62:1199–1203.

    PubMed  Google Scholar 

  14. Brouilette S, Singh RK, Thompson JR, Goodall AH, Samani NJ. White cell telomere length and risk of premature myocardial infarction. Arterioscler Thromb Vasc Biol. 2003;23:842–46.

    Article  PubMed  CAS  Google Scholar 

  15. Ogami M, Ikura Y, Ohsawa M, et al. Telomere shortening in human coronary artery diseases. Arterioscler Thromb Vasc Biol. 2004;24:546–50.

    Article  PubMed  CAS  Google Scholar 

  16. Hansen RS, Wijmenga C, Luo P, et al. The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome. Proc Natl Acad Sci U S A. 1999;96:14412–7.

    Article  PubMed  CAS  Google Scholar 

  17. Yehezkel S, Segev Y, Viegas-Péquignot E, Skorecki K, Selig S. Hypomethylation of subtelomeric regions in ICF syndrome is associated with abnormally short telomeres and enhanced transcription from telomeric regions. Hum Mol Genet. 2008;17:2776–89.

    Article  PubMed  CAS  Google Scholar 

  18. Maeda T, Guan JZ, Oyama J, Higuchi Y, Makino N. Aging-associated alteration in subtelomeric methylation in Parkinson’s disease. J Gerontol A Biol Sci Med Sci. 2009 64:949–955.

    Article  PubMed  Google Scholar 

  19. Maeda T, Guan JZ, Higuchi Y, Oyama J, Makino N. Age-related alterations in subtelomeric methylation in sarcoidosis patients. J Gerontol A Biol Sci Med Sci. 2009 64:752–760.

    Article  PubMed  Google Scholar 

  20. Yamaguchi H, Calado RT, Ly H, et al. Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. N Engl J Med. 2005;352:1413–1424.

    Article  PubMed  CAS  Google Scholar 

  21. Chen W, Gardner JP, Kimura M, et al. Leukocyte telomere length is associated with HDL cholesterol levels: The Bogalusa heart study. Atherosclerosis. 2009;205:620–625

    Article  PubMed  CAS  Google Scholar 

  22. Shay JW, Wright WE. Telomerase therapeutics for cancer: challenges and new directions. Nat Rev Drug Discov. 2006;5:577–584.

    Article  PubMed  CAS  Google Scholar 

  23. van Overveld PG, Lemmers RJ, Sandkuijl LA, et al. Hypomethylation of D4Z4 in 4q-linked and non-4q-linked facioscapulohumeral muscular dystrophy. Nat Genet. 2003;35:315–317.

    Article  PubMed  Google Scholar 

  24. Pedram M, Sprung CN, Gao Q, Lo AW, Reynolds GE, Murnane JP. Telomere position effect and silencing of transgenes near telomeres in the mouse. Mol Cell Biol. 2006;26:1865–1878.

    Article  PubMed  CAS  Google Scholar 

  25. Blanco R, Muñoz P, Flores JM, Klatt P, Blasco MA. Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis. Genes Dev. 2007;21:206–220.

    Article  PubMed  CAS  Google Scholar 

  26. Wu L, Multani AS, He H, et al. Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres. Cell. 2006;126:49–62.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Division of Molecular and Clinical Gerontology, the Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Oita, 874-0838, Japan

    Toyoki Maeda, M. Sasaki & N. Makino

  2. The Department of Cardiovascular, Respiratory, and Geriatric Medicine, Kyushu University Hospital at Beppu, Kyushu University, Oita, 874-0838, Japan

    J. -I. Oyama

  3. Innovation of New Biomedical Engineering Center, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan

    T. Arima

Authors
  1. Toyoki Maeda
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. -I. Oyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Sasaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. Arima
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. N. Makino
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Toyoki Maeda.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Maeda, T., Oyama, J.I., Sasaki, M. et al. The correlation between the clinical laboratory data and the telomere length in peripheral blood leukocytes of Japanese female patients with hypertension. J Nutr Health Aging 15, 240–244 (2011). https://doi.org/10.1007/s12603-010-0137-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12603-010-0137-3

Key words

Search

Navigation