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Cardiac Myocyte–Fibroblast Interactions and the Coronary Vasculature

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Abstract

Treatment of cardiovascular diseases relies on the ability not only to abrogate and compensate for congenital deformities but also to repair cardiac pathologies in the adult. Determining how cells communicate within the myocardium and how to use this communication to repair and treat pathological conditions have been necessary steps in the successful intervention of cardiac diseases. In this regard, research has mostly focused on relationships between the main cellular constituents of the heart, myocytes, and fibroblasts. However, the coronary vasculature is also critical to myocardial organization and integrity, and how the vasculature influences and responds to cues from cardiac myocytes and fibroblasts is largely underappreciated. This review discusses how factors that affect myocyte and fibroblast physiology and communication may also interact with the coronary vasculature. Defining the mechanisms of these cellular relationships will help identify ways to control angiogenesis during cardiac remodeling and the development of tissue-engineered therapies.

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Acknowledgments

This material is the result of work supported with resources and the use of facilities at the Central Texas Veterans Health Care System, Temple, Texas.

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Authors and Affiliations

  1. Texas A&M Health Science Center, Cardiovascular Research Institute, 1901 South First St., Bldg 205, Temple, TX, 76504, USA

    Stephanie L. K. Bowers & Troy A. Baudino

  2. Scott and White Hospital Systems, Department of Medicine, Temple, TX, USA

    Stephanie L. K. Bowers & Troy A. Baudino

  3. Central Texas Veterans Health Administration, Temple, TX, USA

    Stephanie L. K. Bowers & Troy A. Baudino

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Correspondence to Troy A. Baudino.

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Bowers, S.L.K., Baudino, T.A. Cardiac Myocyte–Fibroblast Interactions and the Coronary Vasculature. J. of Cardiovasc. Trans. Res. 5, 783–793 (2012). https://doi.org/10.1007/s12265-012-9407-2

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