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The function of DNA topoisomerase IIβ in neuronal development

拓扑异构酶IIβ在神经发育中的作用

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Abstract

Type II DNA topoisomerases (Tops) are ATP-dependent enzymes that catalyze topological transformations of genomic DNA by the transport of one DNA double helix through another. In mammals, there are 2 isoforms of DNA Top II, termed Top IIα and Top IIβ. The IIβ isoform is abundantly expressed in cells that have undergone the final cell division and are committed to differentiation into neuronal cells. In recent years, there have been accumulating studies showing the significant role of Top IIβ in neuronal development through regulating expression of certain genes in cells committed to the neuronal fate after the final division. These genes are involved in the processes of neuronal differentiation, migration, axon guidance and so on. The present review mainly focused on the research progress on the role of Top IIβ in neuronal development over the recent decades.

摘要

II型DNA拓扑异构酶是一类ATP依赖性酶, 能引导双链DNA绕过另一个双链上的缺口来催化基因组DNA拓扑结构的改变。 在哺乳动物中, II型DNA拓扑异构酶又分为 α 和 β 两个亚型。 β 亚型高表达于已完成终末分裂并能分化为神经细胞的一类细胞中。 近年来, 越来越多的研究表明拓扑异构酶IIβ在神经发育中有至关重要的作用。 细胞进行终末分裂以后, 拓扑异构酶IIβ能够调控决定神经命运的一些特定基因的表达。 这些基因主要与神经分化、 迁移以及轴突导向等过程相关。 本文就近几十年内关于拓扑异构酶IIβ在神经发育中作用的研究进展进行综述。

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References

  1. Wang JC. Cellular roles of DNA topoisomerases: A molecular perspective. Nat Rev Mol Cell Biol 2002, 3:430–440.

    Article  CAS  PubMed  Google Scholar 

  2. Austin CA, Sng JH, Patel S, Fisher LM. Novel hela topoisomerase II is the II beta isoform: Complete coding sequence and homology with other type II topoisomerases. Biochim Biophys Acta 1993, 1172:283–291.

    CAS  PubMed  Google Scholar 

  3. Drake FH, Zimmerman JP, McCabe FL, Bartus HF, Per SR, Sullivan DM, et al. Purification of topoisomerase II from amsacrine-resistant p388 leukemia cells. Evidence for two forms of the enzyme. J Biol Chem 1987, 262:16739–16747.

    CAS  PubMed  Google Scholar 

  4. Jenkins JR, Ayton P, Jones T, Davies SL, Simmons DL, Harris AL, et al. Hickson ID: Isolation of cdna clones encoding the beta isozyme of human DNA topoisomerase II and localisation of the gene to chromosome 3p24. Nucleic Acids Res 1992, 20:5587–5592.

    Article  CAS  PubMed  Google Scholar 

  5. Tan KB, Dorman TE, Falls KM, Chung TD, Mirabelli CK, Crooke ST, et al. Topoisomerase II alpha and topoisomerase II beta genes: Characterization and mapping to human chromosomes 17 and 3, respectively. Cancer Res 1992, 52: 231–234.

    CAS  PubMed  Google Scholar 

  6. Wang JC. DNA topoisomerases. Annu Rev Biochem 1996, 65:635–692.

    Article  CAS  PubMed  Google Scholar 

  7. Watt PM, Hickson ID. Structure and function of type II DNA topoisomerases. Biochem J 1994, 303(Pt 3):681–695.

    CAS  PubMed  Google Scholar 

  8. Caron PR, Wang JC. Appendix. II: Alignment of primary sequences of DNA topoisomerases. Adv Pharmacol 1994, 29B:271–297.

    Article  CAS  PubMed  Google Scholar 

  9. Austin CA, Marsh KL, Wasserman RA, Willmore E, Sayer PJ, Wang JC, et al. Expression, domain structure, and enzymatic properties of an active recombinant human DNA topoisomerase II beta. J Biol Chem 1995, 270:15739–15746.

    Article  CAS  PubMed  Google Scholar 

  10. Zini N, Martelli AM, Sabatelli P, Santi S, Negri C, Astaldi Ricotti GC, et al. The 180-kda isoform of topoisomerase II is localized in the nucleolus and belongs to the structural elements of the nucleolar remnant. Exp Cell Res 1992, 200:460–466.

    Article  CAS  PubMed  Google Scholar 

  11. Drake FH, Hofmann GA, Bartus HF, Mattern MR, Crooke ST, Mirabelli CK. Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II. Biochemistry 1989, 28:8154–8160.

    Article  CAS  PubMed  Google Scholar 

  12. Chaly N, Chen X, Dentry J, Brown DL. Organization of DNA topoisomerase II isotypes during the cell cycle of human lymphocytes and hela cells. Chromosome Res 1996, 4:457–466.

    Article  CAS  PubMed  Google Scholar 

  13. Tsutsui K, Hosoya O, Sano K, Tokunaga A. Immunohistochemical analyses of DNA topoisomerase II isoforms in developing rat cerebellum. J Comp Neurol 2001, 431:228–239.

    Article  CAS  PubMed  Google Scholar 

  14. Meyer KN, Kjeldsen E, Straub T, Knudsen BR, Hickson ID, Kikuchi A, et al. Cell cycle-coupled relocation of types I and II topoisomerases and modulation of catalytic enzyme activities. J Cell Biol 1997, 136:775–788.

    Article  CAS  PubMed  Google Scholar 

  15. Taagepera S, Rao PN, Drake FH, Gorbsky GJ. DNA topoisomerase II alpha is the major chromosome protein recognized by the mitotic phosphoprotein antibody mpm-2. Proc Natl Acad Sci U S A 1993, 90:8407–8411.

    Article  CAS  PubMed  Google Scholar 

  16. Chaly N, Brown DL. Is DNA topoisomerase II beta a nucleolar protein? J Cell Biochem 1996, 63: 162–173.

    Article  CAS  PubMed  Google Scholar 

  17. Kondapi AK, Mulpuri N, Mandraju RK, Sasikaran B, Subba Rao K. Analysis of age dependent changes of topoisomerase II alpha and beta in rat brain. Int J Dev Neurosci 2004, 22:19–30.

    Article  CAS  PubMed  Google Scholar 

  18. Yang X, Li W, Prescott ED, Burden SJ, Wang JC. DNA topoisomerase IIbeta and neural development. Science 2000, 287:131–134.

    Article  CAS  PubMed  Google Scholar 

  19. Lyu YL, Lin CP, Azarova AM, Cai L, Wang JC, Liu LF. Role of topoisomerase IIbeta in the expression of developmentally regulated genes. Mol Cell Biol 2006, 26:7929–7941.

    Article  CAS  PubMed  Google Scholar 

  20. Lyu YL, Wang JC. Aberrant lamination in the cerebral cortex of mouse embryos lacking DNA topoisomerase IIbeta. Proc Natl Acad Sci U S A 2003, 100:7123–7128.

    Article  CAS  PubMed  Google Scholar 

  21. Tsutsui K, Tsutsui K, Sano K, Kikuchi A, Tokunaga A. Involvement of DNA topoisomerase IIbeta in neuronal differentiation. J Biol Chem 2001, 276:5769–5778.

    Article  CAS  PubMed  Google Scholar 

  22. Chen M, Beck WT. Teniposide-resistant cem cells, which express mutant DNA topoisomerase II alpha, when treated with non-complex-stabilizing inhibitors of the enzyme, display no cross-resistance and reveal aberrant functions of the mutant enzyme. Cancer Res 1993, 53:5946–5953.

    CAS  PubMed  Google Scholar 

  23. Allen MP, Xu M, Zeng C, Tobet SA, Wierman ME. Myocyte enhancer factors-2b and -2c are required for adhesion related kinase repression of neuronal gonadotropin releasing hormone gene expression. J Biol Chem 2000, 275:39662–39670.

    Article  CAS  PubMed  Google Scholar 

  24. Garel S, Marin F, Grosschedl R, Charnay P. Ebf1 controls early cell differentiation in the embryonic striatum. Development 1999, 126:5285–5294.

    CAS  PubMed  Google Scholar 

  25. Romm E, Nielsen JA, Kim JG, Hudson LD. Myt1 family recruits histone deacetylase to regulate neural transcription. J Neurochem 2005, 93:1444–1453.

    Article  CAS  PubMed  Google Scholar 

  26. Nur EKA, Meiners S, Ahmed I, Azarova A, Lin CP, Lyu YL, et al. Role of DNA topoisomerase IIbeta in neurite outgrowth. Brain Res 2007, 1154:50–60.

    Article  Google Scholar 

  27. Ju BG, Lunyak VV, Perissi V, Garcia-Bassets I, Rose DW, Glass CK, et al. A topoisomerase IIbeta-mediated dsdna break required for regulated transcription. Science 2006, 312:1798–1802.

    Article  CAS  PubMed  Google Scholar 

  28. Gilbert N, Boyle S, Fiegler H, Woodfine K, Carter NP, Bickmore WA. Chromatin architecture of the human genome: Gene-rich domains are enriched in open chromatin fibers. Cell 2004, 118:555–566.

    Article  CAS  PubMed  Google Scholar 

  29. Sano K, Miyaji-Yamaguchi M, Tsutsui KM, Tsutsui K. Topoisomerase IIbeta activates a subset of neuronal genes that are repressed in AT-rich genomic environment. PLoS One 2008, 3:e4103.

    Article  PubMed  Google Scholar 

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  1. Institute of Health Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, Ruijin Hospital, Shanghai, 200025, China

    Xin Heng  (衡鑫) & Wei-Dong Le  (乐卫东)

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  1. Xin Heng  (衡鑫)
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  2. Wei-Dong Le  (乐卫东)
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Correspondence to Wei-Dong Le  (乐卫东).

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Heng, X., Le, WD. The function of DNA topoisomerase IIβ in neuronal development. Neurosci. Bull. 26, 411–416 (2010). https://doi.org/10.1007/s12264-010-0625-9

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  • DOI: https://doi.org/10.1007/s12264-010-0625-9

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