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Application of an artificial neural network to the computer-aided differentiation of focal liver disease in MR imaging

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Abstract

The differentiation of focal liver lesions in magnetic resonance (MR) imaging is primarily based on the intensity and homogeneity of lesions with different imaging sequences. However, these imaging findings are falsely interpreted in some patients because of the complexities involved. Our aim is to establish a computer-aided diagnosis system named LiverANN for classifying the pathologies of focal liver lesions into five categories using the artificial neural network (ANN) technique. On each MR image, a region of interest (ROI) in the focal liver lesion was delineated by a radiologist. The intensity and homogeneity within the ROI were calculated automatically, producing numerical data that were analyzed by feeding them into the LiverANN as inputs. Outputs were the following five pathologic categories of hepatic disease: hepatic cyst, hepatocellular carcinoma, dysplasia in cirrhosis, cavernous hemangioma, and metastasis. Of the 320 MR images obtained from 80 patients (four images per patient) with liver lesions, our LiverANN classified 50 cases of a training set into five types of liver lesions with a training accuracy of 100% and 30 test cases with a testing accuracy of 93%. The experiment demonstrated that our LiverANN, which functions as a computer-aided differentiation tool, can provide radiologists with a second opinion during the radiologic diagnostic procedure.

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Acknowledgments

This research was supported in part by the National Natural Science Foundations of China (No. 60863014 and 60762001); in part by the Program to Sponsor Teams for Innovation in the Construction of Talent Highlands in Guangxi Institutions of Higher Learning; in part by the National Creative Plan for Undergraduate Students of Guangxi University (No. 200707 and X071036); in part by a research foundation project of the Guangxi Ministry of Education (No. 200810MS048); and in part by a research grant from the Collaborative Centre for Academy/Industry/Government of Gifu University, the Ministry of Health, Labor, and Welfare under a Grant-In-Aid for Cancer Research, and the Ministry of Education, Culture, Sports, Science and Technology under a Grant-In-Aid for Scientific Research by the Japanese Government.

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Correspondence to Xuejun Zhang.

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Zhang, X., Kanematsu, M., Fujita, H. et al. Application of an artificial neural network to the computer-aided differentiation of focal liver disease in MR imaging. Radiol Phys Technol 2, 175–182 (2009). https://doi.org/10.1007/s12194-009-0062-5

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  • DOI: https://doi.org/10.1007/s12194-009-0062-5

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