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Hyperbaric oxygen preconditioning protects skin from UV-A damage

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Cell Stress and Chaperones Aims and scope

Abstract

Hyperbaric oxygen therapy (HBOT) is used for a number of applications, including the treatment of diabetic foot ulcers and CO poisoning. However, we and others have shown that HBOT can mobilize cellular antioxidant defenses, suggesting that it may also be useful under circumstances in which tissue protection from oxidative damage is desired. To test the protective properties of hyperbaric oxygen (HBO) on a tissue level, we evaluated the ability of a preconditioning treatment regimen to protect cutaneous tissue from UV-A-induced oxidative damage. Three groups of hairless SKH1-E mice were exposed to UV-A 3 days per week for 22 weeks, with two of these groups receiving an HBO pretreatment either two or four times per week. UV-A exposure increased apoptosis and proliferation of the skin tissue, indicating elevated levels of epithelial damage and repair. Pretreatment with HBO significantly reduced UV-A-induced apoptosis and proliferation. A morphometric analysis of microscopic tissue folds also showed a significant increase in skin creasing following UV-A exposure, which was prevented by HBO pretreatment. Likewise, skin elasticity was found to be greatest in the group treated with HBO four times per week. The effects of HBO were also apparent systemically as reductions in caspase-3 activity and expression were observed in the liver. Our findings support a protective function of HBO pretreatment from a direct oxidative challenge of UV-A to skin tissue. Similar protection of other tissues may likewise be achievable.

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References

  • Abidia A, Laden G, Kuhan G, Johnson BF, Wilkinson AR, Renwick PM, Masson EA, McCollum PT (2003) The role of hyperbaric oxygen therapy in ischaemic diabetic lower extremity ulcers: a double-blind randomised-controlled trial. Eur J Vasc Endovasc Surg: Off J Eur Soc Vasc Surg 25(6):513–518. doi:10.1053/ejvs.2002.1911

    Article  CAS  Google Scholar 

  • Alex J, Laden G, Cale ARJ, Bennett S, Flowers K, Madden L, Gardiner E, McCollum PT, Griffin SC (2005) Pretreatment with hyperbaric oxygen and its effect on neuropsychometric dysfunction and systemic inflammatory response after cardiopulmonary bypass: a prospective randomized double-blind trial. J Thorac Cardiovasc Surg 130(6):1623–1630. doi:10.1016/j.jtcvs.2005.08.018

    Article  PubMed  Google Scholar 

  • Al-Waili NS, Butler GJ (2006) Effects of hyperbaric oxygen on inflammatory response to wound and trauma: possible mechanism of action. The Scientific World Journal 6:425–441. doi:10.1100/tsw.2006.78

    Article  CAS  Google Scholar 

  • Babchin A, Levich E, Melamed MDY, Sivashinsky G (2011) Osmotic phenomena in application for hyperbaric oxygen treatment. Colloids Surf B: Biointerfaces 83(1):128–132. doi:10.1016/j.colsurfb.2010.11.019

    Article  CAS  Google Scholar 

  • Bell SG, Vallee BL (2009) The metallothionein/thionein system: an oxidoreductive metabolic zinc link. ChemBioChem 10(1):55–62. doi:10.1002/cbic.200800511

    Article  CAS  PubMed  Google Scholar 

  • Benavides F, Oberyszyn TM, VanBuskirk AM, Reeve VE, Kusewitt DF (2009) The hairless mouse in skin research. J Dermatol Sci 53(1):10–18. doi:10.1016/j.jdermsci.2008.08.012

    Article  CAS  PubMed  Google Scholar 

  • Bishop AJ, Mudge E (2012) A retrospective study of diabetic foot ulcers treated with hyperbaric oxygen therapy. Int Wound J. doi:10.1111/j.1742-481X.2011.00936.x

  • Bonomo SR, Davidson JD, Yu Y, Xia Y, Lin X, Mustoe TA (1998) Hyperbaric oxygen as a signal transducer: upregulation of platelet derived growth factor-beta receptor in the presence of HBO2 and PDGF. Undersea Hyperb Med: J Undersea Hyperb Med Soc Inc 25(4):211–216

    CAS  Google Scholar 

  • Boyer JZ, Jandova J, Janda J, Vleugels FR, Elliott DA, Sligh JE (2012) Resveratrol-sensitized UVA induced apoptosis in human keratinocytes through mitochondrial oxidative stress and pore opening. J Photochem Photobiol B: Biol 113:42–50. doi:10.1016/j.jphotobiol.2012.04.013

    Article  CAS  Google Scholar 

  • Buerk DG (2007) Nitric oxide regulation of microvascular oxygen. Antioxid Redox Signal 9(7):829–843. doi:10.1089/ars.2007.1551

    Article  CAS  PubMed  Google Scholar 

  • Buras JA, Stahl GL, Svoboda KK, Reenstra WR (2000) Hyperbaric oxygen downregulates ICAM-1 expression induced by hypoxia and hypoglycemia: the role of NOS. Am J Physiol Cell Physiol 278(2):C292–C302

    CAS  PubMed  Google Scholar 

  • Cabigas BP, Su J, Hutchins W, Shi Y, Schaefer RB, Recinos RF, Nilakantan V, Kindwall E, Niezgoda JA, Baker JE (2006) Hyperoxic and hyperbaric-induced cardioprotection: role of nitric oxide synthase 3. Cardiovasc Res 72(1):143–151. doi:10.1016/j.cardiores.2006.06.031

    Article  CAS  PubMed  Google Scholar 

  • Chavko M, McCarron RM (2006) Extension of brain tolerance to hyperbaric O2 by intermittent air breaks is related to the time of CBF increase. Brain Res 1084(1):196–201. doi:10.1016/j.brainres.2006.02.014

    Article  CAS  PubMed  Google Scholar 

  • Cheng O, Ostrowski RP, Wu B, Liu W, Chen C, Zhang JH (2011) Cyclooxygenase-2 mediates hyperbaric oxygen preconditioning in the rat model of transient global cerebral ischemia. Stroke 42(2):484–490. doi:10.1161/strokeaha.110.604421

    Article  CAS  PubMed  Google Scholar 

  • Cypser JR, Johnson TE (2002) Multiple stressors in Caenorhabditis elegans induce stress hormesis and extended longevity. J Gerontol Ser A: Biol Sci Med Sci 57(3):B109–B114. doi:10.1093/gerona/57.3.B109

    Article  Google Scholar 

  • Daniel RAF, Cardoso VK, Góis E Jr, Parra RS, Garcia SB, Rocha JJ, Féres O (2011) Effect of hyperbaric oxygen therapy on the intestinal ischemia reperfusion injury. Acta Cir Bras 26:463–469

    Article  PubMed  Google Scholar 

  • Dennog C, Radermacher P, Barnett YA, Speit G (1999) Antioxidant status in humans after exposure to hyperbaric oxygen. Mutat Res 428(1–2):83–89

    CAS  PubMed  Google Scholar 

  • Duzgun AP, Satır HZ, Ozozan O, Saylam B, Kulah B, Coskun F (2008) Effect of hyperbaric oxygen therapy on healing of diabetic foot ulcers. J Foot Ankle Surg 47(6):515–519. doi:10.1053/j.jfas.2008.08.002

    Article  PubMed  Google Scholar 

  • El-Abaseri TB, Putta S, Hansen LA (2006) Ultraviolet irradiation induces keratinocyte proliferation and epidermal hyperplasia through the activation of the epidermal growth factor receptor. Carcinogenesis 27(2):225–231. doi:10.1093/carcin/bgi220

    Article  CAS  PubMed  Google Scholar 

  • Faglia E, Favales F, Aldeghi A, Calia P, Quarantiello A, Oriani G, Michael M, Campagnoli P, Morabito A (1996) Adjunctive systemic hyperbaric oxygen therapy in treatment of severe prevalently ischemic diabetic foot ulcer. A randomized study. Diabetes Care 19(12):1338–1343

    Article  CAS  PubMed  Google Scholar 

  • Gentile M, Latonen L, Laiho M (2003) Cell cycle arrest and apoptosis provoked by UV radiation–induced DNA damage are transcriptionally highly divergent responses. Nucleic Acids Res 31(16):4779–4790. doi:10.1093/nar/gkg675

    Article  CAS  PubMed  Google Scholar 

  • Giles TD, Sander GE, Nossaman BD, Kadowitz PJ (2012) Impaired vasodilation in the pathogenesis of hypertension: focus on nitric oxide, endothelial-derived hyperpolarizing factors, and prostaglandins. J Clin Hypertens 14(4):198–205. doi:10.1111/j.1751-7176.2012.00606.x

    Article  CAS  Google Scholar 

  • Gill AL, Bell CNA (2004) Hyperbaric oxygen: its uses, mechanisms of action and outcomes. QJM 97(7):385–395. doi:10.1093/qjmed/hch074

    Article  CAS  PubMed  Google Scholar 

  • Godman C, Chheda K, Hightower L, Perdrizet G, Shin D-G, Giardina C (2010a) Hyperbaric oxygen induces a cytoprotective and angiogenic response in human microvascular endothelial cells. Cell Stress Chaperones 15(4):431–442. doi:10.1007/s12192-009-0159-0

    Article  CAS  PubMed  Google Scholar 

  • Godman CA, Joshi R, Giardina C, Perdrizet G, Hightower LE (2010b) Hyperbaric oxygen treatment induces antioxidant gene expression. Ann N Y Acad Sci 1197(1):178–183. doi:10.1111/j.1749-6632.2009.05393.x

    Article  CAS  PubMed  Google Scholar 

  • Halliday GM (2005) Inflammation, gene mutation and photoimmunosuppression in response to UVR-induced oxidative damage contributes to photocarcinogenesis. Mutat Res Fundam Mol Mech Mutagen 571(1–2):107–120. doi:10.1016/j.mrfmmm.2004.09.013

    Article  CAS  Google Scholar 

  • Han C, Lin L, Zhang W, Zhang L, Lv S, Sun Q, Tao H, Zhang JH, Sun X (2008) Hyperbaric oxygen preconditioning alleviates myocardial ischemic injury in rats. Exp Biol Med 233(11):1448–1453. doi:10.3181/0801-rm-8

    Article  CAS  Google Scholar 

  • He YY, Huang JL, Block ML, Hong JS, Chignell CF (2005) Role of phagocyte oxidase in UVA-induced oxidative stress and apoptosis in keratinocytes. J Investig Dermatol 125(3):560–566. doi:10.1111/j.0022-202X.2005.23851.x

    Article  CAS  PubMed  Google Scholar 

  • He X, Xu X, Fan M, Chen X, Sun X, Luo G, Chen L, Mu Q, Feng Y, Mao Q, Chao Z (2011) Preconditioning with hyperbaric oxygen induces tolerance against renal ischemia–reperfusion injury via increased expression of heme oxygenase-1. J Surg Res 170(2):e271–e277. doi:10.1016/j.jss.2011.06.008

    Article  CAS  PubMed  Google Scholar 

  • Heyneman CA, Lawless-Liday C (2002) Using hyperbaric oxygen to treat diabetic foot ulcers: safety and effectiveness. Crit Care Nurse 22(6):52–60

    PubMed  Google Scholar 

  • Hou W, Tian Q, Steuerwald NM, Schrum LW, Bonkovsky HL (2012) The let-7 microRNA enhances heme oxygenase-1 by suppressing Bach1 and attenuates oxidant injury in human hepatocytes. Biochim Biophys Acta (BBA)—Gene Regul Mech (0). doi:10.1016/j.bbagrm.2012.06.001

  • Hseu Y-C, Chou C-W, Senthil Kumar KJ, Fu K-T, Wang H-M, Hsu L-S, Kuo Y-H, Wu C-R, Chen S-C, Yang H-L (2012) Ellagic acid protects human keratinocyte (HaCaT) cells against UVA-induced oxidative stress and apoptosis through the upregulation of the HO-1 and Nrf-2 antioxidant genes. Food Chem Toxicol 50(5):1245–1255. doi:10.1016/j.fct.2012.02.020

    Article  CAS  PubMed  Google Scholar 

  • Kendall AC, Whatmore JL, Harries LW, Winyard PG, Smerdon GR, Eggleton P (2012) Changes in inflammatory gene expression induced by hyperbaric oxygen treatment in human endothelial cells under chronic wound conditions. Exp Cell Res 318(3):207–216. doi:10.1016/j.yexcr.2011.10.014

    Article  CAS  PubMed  Google Scholar 

  • Kessler L, Bilbault P, Ortéga F, Grasso C, Passemard R, Stephan D, Pinget M, Schneider F (2003) Hyperbaric oxygenation accelerates the healing rate of nonischemic chronic diabetic foot ulcers. Diabetes Care 26(8):2378–2382. doi:10.2337/diacare.26.8.2378

    Article  PubMed  Google Scholar 

  • Krutmann J (2000) Ultraviolet A radiation-induced biological effects in human skin: relevance for photoaging and photodermatosis. J Dermatol Sci 23(Supplement 1 (0)):S22–S26. doi:10.1016/s0923-1811(99)00077-8

    Article  CAS  PubMed  Google Scholar 

  • Kujoth GC, Hiona A, Pugh TD, Someya S, Panzer K, Wohlgemuth SE, Hofer T, Seo AY, Sullivan R, Jobling WA, Morrow JD, Van Remmen H, Sedivy JM, Yamasoba T, Tanokura M, Weindruch R, Leeuwenburgh C, Prolla TA (2005) Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 309(5733):481–484. doi:10.1126/science.1112125

    Article  CAS  PubMed  Google Scholar 

  • Kuratnik A, Senapati VE, Verma R, Mellone BG, Vella AT, Giardina C (2012) Acute sensitization of colon cancer cells to inflammatory cytokines by prophase arrest. Biochem Pharmacol 83(9):1217–1228. doi:10.1016/j.bcp.2012.01.024

    Article  CAS  PubMed  Google Scholar 

  • Lee Y, Cha H, Hong M, Yoon Y, Lee H, An S (2012) Role of NF-κB–p53 crosstalk in ultraviolet A-induced cell death and G1 arrest in human dermal fibroblasts. Arch Dermatol Res 304(1):73–79. doi:10.1007/s00403-011-1176-2

    Article  CAS  PubMed  Google Scholar 

  • Li J, Liu W, Ding S, Xu W, Guan Y, Zhang JH, Sun X (2008) Hyperbaric oxygen preconditioning induces tolerance against brain ischemia–reperfusion injury by upregulation of antioxidant enzymes in rats. Brain Res 1210:223–229. doi:10.1016/j.brainres.2008.03.007

    Article  CAS  PubMed  Google Scholar 

  • Li JS, Zhang W, Kang ZM, Ding SJ, Liu WW, Zhang JH, Guan YT, Sun XJ (2009) Hyperbaric oxygen preconditioning reduces ischemia–reperfusion injury by inhibition of apoptosis via mitochondrial pathway in rat brain. Neuroscience 159(4):1309–1315. doi:10.1016/j.neuroscience.2009.01.011

    Article  CAS  PubMed  Google Scholar 

  • Lin S, Shyu K-G, Lee C-C, Wang B-W, Chang C-C, Liu Y-C, Huang F-Y, Chang H (2002) Hyperbaric oxygen selectively induces angiopoietin-2 in human umbilical vein endothelial cells. Biochem Biophys Res Commun 296(3):710–715. doi:10.1016/s0006-291x(02)00924-5

    Article  CAS  PubMed  Google Scholar 

  • Lin CD, Wei IH, Lai CH, Hsia TC, Kao MC, Tsai MH, Wu CH (2011) Hyperbaric oxygen upregulates cochlear constitutive nitric oxide synthase. BMC Neurosci 12:21. doi:10.1186/1471-2202-12-21

    Article  CAS  PubMed  Google Scholar 

  • Lin KC, Niu KC, Tsai KJ, Kuo JR, Wang LC, Chio CC, Chang CP (2012) Attenuating inflammation but stimulating both angiogenesis and neurogenesis using hyperbaric oxygen in rats with traumatic brain injury. J Trauma Acute Care Surg 72(3):650–659. doi:10.1097/TA.0b013e31823c575f

    CAS  PubMed  Google Scholar 

  • Liu W, Li J, Sun X, Liu K, Zhang JH, Xu W, Tao H (2008) Repetitive hyperbaric oxygen exposures enhance sensitivity to convulsion by upregulation of eNOS and nNOS. Brain Res 1201:128–134. doi:10.1016/j.brainres.2008.01.068

    Article  CAS  PubMed  Google Scholar 

  • Londahl M (2012) Hyperbaric oxygen therapy as treatment of diabetic foot ulcers. Diabetes Metab Res Rev 28(Suppl 1):78–84. doi:10.1002/dmrr.2256

    Article  PubMed  Google Scholar 

  • Londahl M, Landin-Olsson M, Katzman P (2011) Hyperbaric oxygen therapy improves health-related quality of life in patients with diabetes and chronic foot ulcer. Diabet Med: J Br Diabet Assoc 28(2):186–190. doi:10.1111/j.1464-5491.2010.03185.x

    Article  CAS  Google Scholar 

  • Marrot L, Belaïdi J-P, Jones C, Perez P, Meunler J-R (2005) Molecular responses to stress induced in normal human Caucasian melanocytes in culture by exposure to simulated solar UV. Photochem Photobiol 81(2):367–375. doi:10.1111/j.1751-1097.2005.tb00196.x

    Article  CAS  PubMed  Google Scholar 

  • Martins I, Galluzzi L, Kroemer G (2011) Hormesis, cell death and aging. Aging 3(9):821–828

    CAS  PubMed  Google Scholar 

  • Matsunami T, Sato Y, Sato T, Ariga S, Shimomura T, Yukawa M (2009) Oxidative stress and gene expression of antioxidant enzymes in the streptozotocin-induced diabetic rats under hyperbaric oxygen exposure. Int J Clin Exp Pathol 3(2):177–188

    PubMed  Google Scholar 

  • Matsunami T, Sato Y, Hasegawa Y, Ariga S, Kashimura H, Sato T, Yukawa M (2011) Enhancement of reactive oxygen species and induction of apoptosis in streptozotocin-induced diabetic rats under hyperbaric oxygen exposure. Int J Clin Exp Pathol 4(3):255–266

    CAS  PubMed  Google Scholar 

  • Morita A, Grewe M, Grether-Beck S, Olaizola-Horn S, Krutmann J (1997) Induction of proinflammatory cytokines in human epidermoid carcinoma cells by in vitro ultraviolet A1 irradiation. Photochem Photobiol 65(4):630–635. doi:10.1111/j.1751-1097.1997.tb01904.x

    Article  CAS  PubMed  Google Scholar 

  • Padgaonkar VA, Giblin FJ, Fowler K, Leverenz VR, Reddan JR, Dziedzic DC (1997) Heme oxygenase synthesis is induced in cultured lens epithelium by hyperbaric oxygen or puromycin. Exp Eye Res 65(3):435–443. doi:10.1006/exer.1997.0356

    Article  CAS  PubMed  Google Scholar 

  • Panteleyev AA, Paus R, Ahmad W, Sundberg JP, Christiano AM (1998) Molecular and functional aspects of the hairless (hr) gene in laboratory rodents and humans. Exp Dermatol 7(5):249–267. doi:10.1111/j.1600-0625.1998.tb00295.x-i1

    Article  CAS  PubMed  Google Scholar 

  • Phillipson RP, Tobi SE, Morris JA, McMillan TJ (2002) UV-A induces persistent genomic instability in human keratinocytes through an oxidative stress mechanism. Free Radic Biol Med 32(5):474–480. doi:10.1016/s0891-5849(01)00829-2

    Article  CAS  PubMed  Google Scholar 

  • Poljsak B, Dahmane R (2012) Free radicals and extrinsic skin aging. Dermatol Res Pract 2012:135206. doi:10.1155/2012/135206

    PubMed  Google Scholar 

  • Pustisek N, Situm M (2011) UV-radiation, apoptosis and skin. Coll Antropologicum 35(Suppl 2):339–341

    Google Scholar 

  • Rebane A, Zimmermann M, Aab A, Baurecht H, Koreck A, Karelson M, Abram K, Metsalu T, Pihlap M, Meyer N, Fölster-Holst R, Nagy N, Kemeny L, Kingo K, Vilo J, Illig T, Akdis M, Franke A, Novak N, Weidinger S, Akdis CA (2012) Mechanisms of IFN-γ-induced apoptosis of human skin keratinocytes in patients with atopic dermatitis. J Allergy Clin Immunol 129(5):1297–1306. doi:10.1016/j.jaci.2012.02.020

    Article  CAS  PubMed  Google Scholar 

  • Rigatti MJ, Verma R, Belinsky GS, Rosenberg DW, Giardina C (2012) Pharmacological inhibition of Mdm2 triggers growth arrest and promotes DNA breakage in mouse colon tumors and human colon cancer cells. Mol Carcinog 51(5):363–378. doi:10.1002/mc.20795

    Article  CAS  PubMed  Google Scholar 

  • Rinaldi B, Cuzzocrea S, Donniacuo M, Capuano A, Di Palma D, Imperatore F, Mazzon E, Di Paola R, Sodano L, Rossi F (2011) Hyperbaric oxygen therapy reduces the Toll-like receptor signaling pathway in multiple organ failures. Intensive Care Med 37(7):1110–1119. doi:10.1007/s00134-011-2241-1

    Article  CAS  PubMed  Google Scholar 

  • Rock KL (2009) Pathobiology of inflammation to cell death. Biol Blood Marrow Transplant: J Am Soc Blood Marrow Transplant 15(1 Suppl):137–138. doi:10.1016/j.bbmt.2008.11.007

    Article  Google Scholar 

  • Rothfuss A, Speit G (2002) Investigations on the mechanism of hyperbaric oxygen (HBO)-induced adaptive protection against oxidative stress. Mutat Res Fundam Mol Mech Mutagen 508(1–2):157–165. doi:10.1016/s0027-5107(02)00213-0

    Article  CAS  Google Scholar 

  • Rothfuss A, Radermacher P, Speit G (2001) Involvement of heme oxygenase-1 (HO-1) in the adaptive protection of human lymphocytes after hyperbaric oxygen (HBO) treatment. Carcinogenesis 22(12):1979–1985. doi:10.1093/carcin/22.12.1979

    Article  CAS  PubMed  Google Scholar 

  • Ruvolo EC Jr, Stamatas GN, Kollias N (2007) Skin viscoelasticity displays site- and age-dependent angular anisotropy. Ski Pharmacol Physiol 20(6):313–321

    Article  Google Scholar 

  • Saglam M, Bozlar U, Kantarci F, Ay H, Battal B, Coskun U (2008) Effect of hyperbaric oxygen on flow-mediated vasodilation. J Ultrasound Med 27(2):209–214

    PubMed  Google Scholar 

  • Schafer P (2012) Apremilast mechanism of action and application to psoriasis and psoriatic arthritis. Biochem Pharmacol 83(12):1583–1590. doi:10.1016/j.bcp.2012.01.001

    Article  CAS  PubMed  Google Scholar 

  • Shiraishi N, Aono K, Utsumi K (1983) Increased metallothionein content in rat liver induced by X irradiation and exposure to high oxygen tension. Radiat Res 95(2):298–302

    Article  CAS  PubMed  Google Scholar 

  • Shyu KG, Wang BW, Chang H (2009) Hyperbaric oxygen activates discoidin domain receptor 2 via tumour necrosis factor-alpha and the p38 MAPK pathway to increase vascular smooth muscle cell migration through matrix metalloproteinase 2. Clin Sci (Lond) 116(7):575–583. doi:10.1042/CS20080215

    Article  CAS  Google Scholar 

  • Simsek K, Ay H, Topal T, Ozler M, Uysal B, Ucar E, Acikel CH, Yesilyurt O, Korkmaz A, Oter S, Yildiz S (2011) Long-term exposure to repetitive hyperbaric oxygen results in cumulative oxidative stress in rat lung tissue. Inhal Toxicol 23(3):166–172. doi:doi:10.3109/08958378.2011.558528

    Article  PubMed  Google Scholar 

  • Sommerfeld B (2007) Randomised, placebo-controlled, double-blind, split-face study on the clinical efficacy of Tricutan® on skin firmness. Phytomedicine 14(11):711–715. doi:10.1016/j.phymed.2007.09.015

    Article  CAS  PubMed  Google Scholar 

  • Sun Q, Sun Q, Liu Y, Sun X, Tao H (2011) Anti-apoptotic effect of hyperbaric oxygen preconditioning on a rat model of myocardial infarction. J Surg Res 171(1):41–46. doi:10.1016/j.jss.2010.01.036

    Article  CAS  PubMed  Google Scholar 

  • Svobodová A, Vostálová J (2010) Solar radiation induced skin damage: review of protective and preventive options. Int J Radiat Biol 86(12):999–1030. doi:doi:10.3109/09553002.2010.501842

    Article  PubMed  Google Scholar 

  • Svobodova AR, Galandakova A, Sianska J, Dolezal D, Ulrichova J, Vostalova J (2011) Acute exposure to solar simulated ultraviolet radiation affects oxidative stress-related biomarkers in skin, liver and blood of hairless mice. Biol Pharm Bull 34(4):471–479

    Article  PubMed  Google Scholar 

  • Svobodová A, Galandáková A, Šianská J, Doležal D, Lichnovská R, Ulrichová J, Vostálová J (2012) DNA damage after acute exposure of mice skin to physiological doses of UVB and UVA light. Arch Dermatol Res 304:407–412. doi:10.1007/s00403-012-1212-x

    Google Scholar 

  • Thackham JA, McElwain DLS, Long RJ (2008) The use of hyperbaric oxygen therapy to treat chronic wounds: a review. Wound Repair Regen 16(3):321–330. doi:10.1111/j.1524-475X.2008.00372.x

    Article  PubMed  Google Scholar 

  • Thom SR (2009) Oxidative stress is fundamental to hyperbaric oxygen therapy. J Appl Physiol 106(3):988–995. doi:10.1152/japplphysiol.91004.2008

    Article  CAS  PubMed  Google Scholar 

  • Tiaka EK, Papanas N, Manolakis AC, Maltezos E (2012) The role of hyperbaric oxygen in the treatment of diabetic foot ulcers. Angiology 63(4):302–314. doi:10.1177/0003319711416804

    Article  PubMed  Google Scholar 

  • Uhoda E, Piérard GE (2003) Irritation cutanée et vitesse de propagation d'ondes ultrasonores. Int J Cosmet Sci 25(1/2):31–35. doi:10.1046/j.1467-2494.2003.00170.x

    Article  CAS  PubMed  Google Scholar 

  • Verma R, Rigatti MJ, Belinsky GS, Godman CA, Giardina C (2010) DNA damage response to the Mdm2 inhibitor nutlin-3. Biochem Pharmacol 79(4):565–574. doi:10.1016/j.bcp.2009.09.020

    Article  CAS  PubMed  Google Scholar 

  • von Neubeck C, Shankaran H, Karin NJ, Kauer PM, Chrisler WB, Wang X, Robinson RJ, Waters KM, Tilton SC, Sowa MB (2012) Cell type-dependent gene transcription profile in a three-dimensional human skin tissue model exposed to low doses of ionizing radiation: implications for medical exposures. Environ Mol Mutagen 53(4):247–259. doi:10.1002/em.21682

    Article  Google Scholar 

  • Wang BW, Lin CM, Wu GJ, Shyu KG (2011) Tumor necrosis factor-alpha enhances hyperbaric oxygen-induced visfatin expression via JNK pathway in human coronary arterial endothelial cells. J Biomed Sci 18:27. doi:10.1186/1423-0127-18-27

    Article  PubMed  Google Scholar 

  • Wu N-L, Fang J-Y, Chen M, Wu C-J, Huang C-C, Hung C-F (2011) Chrysin protects epidermal keratinocytes from UVA- and UVB-induced damage. J Agric Food Chem 59(15):8391–8400. doi:10.1021/jf200931t

    Article  CAS  PubMed  Google Scholar 

  • Xu X, Wang Z, Li Q, Xiao X, Lian Q, Xu W, Sun X, Tao H, Li R (2009) Endothelial nitric oxide synthase expression is progressively increased in primary cerebral microvascular endothelial cells during hyperbaric oxygen exposure. Oxidative Med Cell Longev 2(1):7–13

    Article  Google Scholar 

  • Xue W, Liu Q, Cai L, Wang Z, Feng W (2009) Stable overexpression of human metallothionein-IIA in a heart-derived cell line confers oxidative protection. Toxicol Lett 188(1):70–76. doi:10.1016/j.toxlet.2009.03.007

    Article  CAS  PubMed  Google Scholar 

  • Yildiz S, Aktas S, Cimsit M, Ay H, Togrol E (2004) Seizure incidence in 80,000 patient treatments with hyperbaric oxygen. Aviat, Space, Environ Med 75(11):992–994

    Google Scholar 

  • Zhang Y, Chong E, Herman B (2002) Age-associated increases in the activity of multiple caspases in Fisher 344 rat organs. Exp Gerontol 37(6):777–789. doi:10.1016/s0531-5565(02)00013-x

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

We are indebted to Dr. Rajeev Verma, Saryn Kunajukr, and Kousanee Chheda for their help in treating animals and preparing tissues for analysis. We also thank Aashay Vyas for his assistance in developing and performing the skin micro-creasing analysis. The OxyHeal Health Group provided the hyperbaric chamber for these studies as well as some of the funding.

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Authors and Affiliations

  1. Department of Molecular and Cell Biology, University of Connecticut, 91 North Eagleville Road, U3125, Storrs, CT, 06269, USA

    Ashley M. Fuller, Charles Giardina, Lawrence E. Hightower & Cassandra A. Tierney

  2. Wound Recovery and Hyperbaric Medicine Center, Kent Hospital, Warwick, RI, 02886, USA

    George A. Perdrizet

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  1. Ashley M. Fuller
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  2. Charles Giardina
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Correspondence to Cassandra A. Tierney.

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Fuller, A.M., Giardina, C., Hightower, L.E. et al. Hyperbaric oxygen preconditioning protects skin from UV-A damage. Cell Stress and Chaperones 18, 97–107 (2013). https://doi.org/10.1007/s12192-012-0362-2

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  • DOI: https://doi.org/10.1007/s12192-012-0362-2

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