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Successful treatment of young-onset adult T cell leukemia/lymphoma and preceding chronic refractory eczema and corneal injury by allogeneic hematopoietic stem cell transplantation

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Abstract

Only some carriers of human T cell lymphotropic virus type I (HTLV-1) develop adult T cell leukemia/lymphoma (ATLL) after a long latency period, and an association has been reported between chronic refractory eczema, known as infective dermatitis, and young-onset ATLL. A 25-year-old female developed ATLL and underwent allogeneic hematopoietic stem cell transplantation (HSCT) in non-remission. She had chronic refractory eczema and corneal injury at the onset of ATLL. Remission of ATLL was achieved, and the HTLV-1 proviral load decreased after HSCT. In addition, her pre-existing eczema and corneal injuries almost disappeared. More than a year has passed since the transplantation was performed, and she has had no recurrence of either ATLL or lesions in the skin and eye. Her clinical course suggests a possible association between skin and eye lesions and HTLV-1 infection. Changes in the immunological condition after HSCT might play a key role. Special attention is needed when HTLV-1 carriers develop eye or skin lesions.

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Authors and Affiliations

  1. Division of Hematology, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya-ku, Saitama, Saitama, 330-8503, Japan

    Fumiya Miyamura, Shinichi Kako, Ken Sato, Miki Sato, Kiriko Terasako, Shun-ichi Kimura, Hideki Nakasone, Shinya Okuda, Rie Yamazaki, Kumi Oshima, Takakazu Higuchi, Junji Nishida & Yoshinobu Kanda

  2. Division of Ophthalmology, Saitama Medical Center, Jichi Medical University, Saitama, Japan

    Hiroko Yamagami & Akihiro Kakehashi

  3. Department of Dermatology, Tokyo Women’s Medical University, Tokyo, Japan

    Satoko Aoki

  4. Department of Hematology, Tokyo Women’s Medical University, Tokyo, Japan

    Kentaro Yoshinaga

  5. Division of Dermatology, Saitama Medical Center, Jichi Medical University, Saitama, Japan

    Toshio Demitsu

Authors
  1. Fumiya Miyamura
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  2. Shinichi Kako
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  3. Hiroko Yamagami
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  4. Ken Sato
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  5. Miki Sato
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  7. Shun-ichi Kimura
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  9. Satoko Aoki
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  10. Shinya Okuda
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  13. Kentaro Yoshinaga
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  14. Takakazu Higuchi
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  15. Junji Nishida
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  16. Toshio Demitsu
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  17. Akihiro Kakehashi
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  18. Yoshinobu Kanda
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Corresponding author

Correspondence to Yoshinobu Kanda.

Additional information

F. Miyamura, S. Kako and H. Yamagami contributed equally to this work.

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Miyamura, F., Kako, S., Yamagami, H. et al. Successful treatment of young-onset adult T cell leukemia/lymphoma and preceding chronic refractory eczema and corneal injury by allogeneic hematopoietic stem cell transplantation. Int J Hematol 90, 397–401 (2009). https://doi.org/10.1007/s12185-009-0406-2

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  • DOI: https://doi.org/10.1007/s12185-009-0406-2

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