Skip to main content

Advertisement

SpringerLink
Log in

Ion mobility spectrometry for the rapid analysis of over-the-counter drugs and beverages

  • Original Research
  • Published:
International Journal for Ion Mobility Spectrometry

Abstract

In the pharmaceutical industry, there are increasing requirements for analytical methods in quality assessment for the production of drugs. In this investigation, ion mobility spectrometry (IMS) was used for the rapid qualitative separation and identification of active ingredients in generic over-the-counter drugs and food additives in beverages. The active ingredients determined in drugs were acetaminophen, aspartame, bisacodyl, caffeine, dextromethorphan, diphenhydramine, famotidine, glucosamine, guaifenesin, loratadine, niacin, phenylephrine, pyridoxine, thiamin, and tetrahydrozoline. Aspartame and caffeine were determined in beverages. Fourteen over-the-counter drugs and beverages were analyzed. Analysis times below 10 s were obtained for IMS, and reduced mobilities were reported for the first time for 12 compounds. A quadrupole mass spectrometer coupled to a mobility spectrometer was used to assure a correct peak assignation. The combination of fast analysis, low cost, and inexpensive maintenance of IMS instruments makes IMS an attractive technique for the qualitative determination of the active ingredients in over-the-counter drugs and food additives in manufacture quality control and cleaning verification for the drug and food industries.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Asbury GR, Klasmeier J, Hill HH Jr (2000) Talanta 50:1291–1298

    Article  CAS  Google Scholar 

  2. Hill HH Jr, Simpson G (1997) Field Anal Chem Technol 1:119–134

    Article  Google Scholar 

  3. Huff J, LaDou J (2007) Int J Occup Environ Health 13:446–448

    Google Scholar 

  4. Shumate C, St Louis RH, Hill HH Jr (1986) J Chromatogr 373:141–173

    Article  CAS  Google Scholar 

  5. Wu C, Siems WF, Asbury GR, Hill HH (1998) Anal Chem 70:4929–4938

    Article  CAS  Google Scholar 

  6. Dwivedi P, Bendiak B, Clowers BH, Hill HH Jr (2007) J Am Soc Mass Spectrom 18:1163–1175

    Article  CAS  Google Scholar 

  7. Eiceman GA, Nazarov EG, Stone JA (2003) Anal Chim Acta 493:185–194

    Article  CAS  Google Scholar 

  8. Mason EA, Schamp HW Jr (1958) Ann Phys 4:233–270

    Article  CAS  Google Scholar 

  9. Karasek FW, Hill HH, Kim SH (1976) J Chromatogr 117:327–336

    Article  CAS  Google Scholar 

  10. Shumate CB, Hill HH (1989) Anal Chem 61:601–606

    Article  CAS  Google Scholar 

  11. Payne K, Fawber W, Faria J, Buaron J, DeBono R, Mahmood A (2005) Spectroscopy Magazine Online 24–27. http://www.forumsci.co.il/newsletters/IMS-for-Cleaning-Verification.doc Accessed February 12, 2009

  12. Williamson CS (2008) Nutr Bull 33:4–7

    Article  Google Scholar 

  13. Eckers C, Laures AM-F, Giles K, Major H, Pringle S (2007) Rapid Commun Mass Spectrom 21:1255–1263

    Article  CAS  Google Scholar 

  14. Waltman MJ, Dwivedi P, Hill HH Jr, Blanchard WC, Ewing RG (2008) Talanta 77(1):249–255

    Article  CAS  Google Scholar 

  15. Asbury GR, Wu C, Siems WF, Hill HH Jr (2000) Anal Chim Acta 404:273–283

    Article  CAS  Google Scholar 

  16. Liu X, Valentine SJ, Plasencia MD, Trimpin S, Naylor S, Clemmer DE (2007) J Am Soc Mass Spectrom 18:1249–1264

    Article  CAS  Google Scholar 

  17. Heydari R (2008) Anal Lett 41:965–976

    Article  CAS  Google Scholar 

  18. Wüthrich B (1993) Ann Allergy 71:379–384

    Google Scholar 

  19. Lee D-S, Wu C, Hill HH Jr (1998) J Chrom A 822:1–9

    Article  CAS  Google Scholar 

  20. McLean JA, Ridenour WB, Caprioli RM (2007) J Mass Spectrom 42:1099–1105

    Article  CAS  Google Scholar 

  21. McMinn DG, Kinzer JA, Shumate CB, Siems WF, Hill HH Jr (1990) J Microcol Sep 2:188–192

    Article  CAS  Google Scholar 

  22. Chiarello-Ebner K (2006) Pharm Techn Pharm Technol 30:52–64

    Google Scholar 

  23. Mason EA, McDaniel EW (1988) Transport properties of ions in gases. Wiley, New York

    Book  Google Scholar 

  24. Wittmer D, Chen YH, Luckenbill BK, Hill HH (1994) Anal Chem 66:2348–2355

    Article  CAS  Google Scholar 

  25. Dwivedi P, Wu P, Klopsch SJ, Puzon GJ, Xun L, Hill HH Jr (2008) Metabolomics 4:63–80

    Article  CAS  Google Scholar 

  26. Siems WF, Wu C, Asbury GR, Tarver EE, Hill HH, Larsen PR, McMinn D (1994) Anal Chem 66:4195–4201

    Article  CAS  Google Scholar 

  27. Kaddis CS, Lomeli SH, Yin S, Berhane B, Apostol MI, Kickhoefer VA, Rome LH, Loo JA (2007) J Am Soc Mass Spectrom 18:1206–1216

    Article  CAS  Google Scholar 

  28. O’Donnell RM, Sun X, Harrington PB (2008) Trends Anal Chem 27:44–53

    Article  Google Scholar 

  29. Weston DJ, Bateman R, Wilson ID, Wood TR, Creaser CS (2005) Anal Chem 77:7572–7580

    Article  CAS  Google Scholar 

  30. Cohen MJ, Karasek FW (1970) J Chromatogr Sci 8:330–337

    CAS  Google Scholar 

  31. McCann D, Barrett A, Cooper A et al (2007) Lancet 370:1560–1567

    Article  CAS  Google Scholar 

  32. Wongiel S, Hymete A, Mohammed AIM (2008) Ethiopian Pharm J 26:39–48

    CAS  Google Scholar 

  33. Andreatta MM, Munoz SE, Lantieri MJ, Eynard AR, Navarro A (2008) Argentina Preventive Medicine 47:136–139

    Article  CAS  Google Scholar 

  34. Tan Y, DeBono R (2004) Today’s Chemist at Work November p 15

  35. Chen YH, Hill HH Jr (1994) J Microcol Sep 6:515–524

    Article  CAS  Google Scholar 

  36. Weihrauch MR, Diehl V (2004) Ann Oncol 15:1460–1465

    Article  CAS  Google Scholar 

  37. Eiceman GA, Blyth DA, Shoff DB, Snyder PA (1990) Anal Chem 62:1374–1379

    Article  CAS  Google Scholar 

  38. Taraszka JA, Gao X, Valentine SJ, Sowell RA, Koeniger SL, Miller DF, Kaufman TC, Clemmer DE (2005) J Proteome Res 4:1238

    Article  CAS  Google Scholar 

  39. Budimir N, Weston DJ, Creaser CS (2007) Analyst (Cambridge, UK) 132:34–40

    CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by NIH grant R33DK0702740351. The authors thank the Graduate professional Writing Center in WSU for proofreading the manuscript.

Author information

Author notes

  1. Roberto Fernández-Maestre

    Present address: Programa de Quimica, Campus de Zaragocilla, Universidad de Cartagena, Cartagena, Colombia

Authors and Affiliations

  1. Department of Chemistry, Washington State University, Pullman, WA, 99163, USA

    Roberto Fernández-Maestre & Herbert H. Hill Jr.

Authors
  1. Roberto Fernández-Maestre
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Herbert H. Hill Jr.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Herbert H. Hill Jr..

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fernández-Maestre, R., Hill, H.H. Ion mobility spectrometry for the rapid analysis of over-the-counter drugs and beverages. Int. J. Ion Mobil. Spec. 12, 91–102 (2009). https://doi.org/10.1007/s12127-009-0025-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12127-009-0025-x

Keywords

Search

Navigation