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Hyalinizing Clear Cell Carcinoma: Report of Eight Cases and a Review of Literature

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Abstract

Hyalinizing clear cell carcinoma (HCCC) is an extremely rare neoplasm with a female predominance, composed of nests of monomorphic clear cells within a hyaline stroma. This tumor often follows an indolent course and treatment includes wide surgical excision with or without adjuvant radiotherapy. We report eight cases of HCCC identified at two academic institutions in six women and two men, ranging in age from 25 to 86 years. Histologically, all cases demonstrated cords, trabeculae, and nests of monomorphic clear cells as well as cells with eosinophilic granular cytoplasm. Mild cellular atypia was occasionally seen and mitoses were very rare. Seven cases demonstrated a hyalinized stroma, and one case, a myxoid stroma. Immunohistochemically, the tumor cells were positive for epithelial markers and negative for desmin and actin. Seven cases were negative for S-100. Cells were also positive for periodic acid-Schiff and negative for mucin. The important clinicopathologic features and the differential diagnoses of HCCC, as well as a review of the literature are discussed.

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References

  1. Milchgrub S, Gnepp DR, Vuitch F, et al. Hyalinizing clear cell carcinoma of the salivary gland. Am J Surg Pathol. 1994;18(1):74–82.

    Article  PubMed  CAS  Google Scholar 

  2. Tang SK, Wan SK, Chan JK. Hyalinizing clear cell carcinoma of salivary gland: report of a case with multiple recurrences over 12 years. Am J Surg Pathol. 1995;19(2):240–1.

    Article  PubMed  CAS  Google Scholar 

  3. Okón K, Modrzejewski M, Strék P. Hyalinizing clear cell carcinoma of the salivary gland. A case report. Pol J Pathol. 1996;47(1):33–6.

    PubMed  Google Scholar 

  4. Urban SD, Deith DA, Goodman M. Hyalinizing clear cell carcinoma: report of a case. J Oral Pathol Med. 1996;25(10):562–4.

    Article  PubMed  CAS  Google Scholar 

  5. Rinaldo A, McLaren KM, Boccato P, et al. Hyalinizing clear cell carcinoma of the oral cavity and of the parotid gland. ORL J Otorhinolaryngol Relat Spec. 1999;61(1):48–51.

    PubMed  CAS  Google Scholar 

  6. Berho M, Huvos AG. Central hyalinizing clear cell carcinoma of the mandible and the maxilla a clinicopathologic study of two cases with an analysis of the literature. Hum Pathol. 1999;30(1):101–5.

    Article  PubMed  CAS  Google Scholar 

  7. Ereño C, Grande J, Alija V, Yamoz J, et al. Hyalinizing clear cell carcinoma of the hypopharynx metastasizing to the lung: a case report. Histopathology. 2000;37(1):89–91.

    Article  PubMed  Google Scholar 

  8. Milchgrub S, Vuitch F, Saboorian MH, et al. Hyalinizing clear cell carcinoma of salivary glands in fine-needle aspiration. Diagn Cytopathol. 2000;23(5):333–7.

    Article  PubMed  CAS  Google Scholar 

  9. Boccato P, Rinaldo A, McLaren KM. A rare tumor of salivary gland origin: hyalinizing clear cell carcinoma. ORL J Otorhinolaryngol Relat Spec. 2001;63(2):119–20.

    PubMed  CAS  Google Scholar 

  10. Grenevicki LF, Barker BF, Fiorella RM, et al. Clear cell carcinoma of the palate. Int J Oral Maxillofac Surg. 2001;30:452–4.

    Article  PubMed  CAS  Google Scholar 

  11. Manoharan M, Othman NH, Samsudin AR. Hyalinizing clear cell carcinoma of minor salivary gland: case report. Braz Dent J. 2002;12(1):66–9.

    Google Scholar 

  12. Félix A, Rosa JC, Nunes JF, et al. Hyalinizing clear cell carcinoma of salivary glands: a study of extracellular matrix. Oral Oncol. 2002;38(4):364–8.

    Article  PubMed  Google Scholar 

  13. Balakrishnan R, Nayak DR, Pillai S, et al. Hyalinizing clear cell carcinoma of the base of the tongue. J Laryngol Otol. 2002;116(10):851–3.

    Article  PubMed  CAS  Google Scholar 

  14. Browne JD, Holland BW. Combined intraoral and lateral temporal approach for palatal malignancies with temporalis muscle reconstruction. Arch Otolaryngol Head Neck Surg. 2002;128:531–7.

    PubMed  Google Scholar 

  15. O’Regan E, Shandilya M, Gnepp DR, et al. Hyalinizing clear cell carcinoma of salivary gland: an aggressive variant. Oral Oncol. 2004;40(3):348–52.

    Article  PubMed  Google Scholar 

  16. Chao TK, Tsai CC, Yeh SY, et al. Hyalinizing clear cell carcinoma of the hard palate. J Laryngol Otol. 2004;118(5):382–4.

    Article  PubMed  Google Scholar 

  17. Suzuki H, Katoh A, Udaka T, et al. Hyalinizing clear cell carcinoma arising from the base of the tongue. Acta Otolaryngol. 2006;126(6):653–6.

    Article  PubMed  Google Scholar 

  18. Meer S, Altini M. CK7+/CK20- immunoexpression profile is typical of salivary gland neoplasia. Histopathology. 2007;51(1):26–32.

    Article  PubMed  CAS  Google Scholar 

  19. Pujary K, Rangarajan S, Nayak DR, et al. Hyalinizing clear cell carcinoma of the base of tongue. Int J Oral Maxillofac Surg. 2008;37(1):93–6.

    Article  PubMed  CAS  Google Scholar 

  20. Angiero F, Stefani M. Hyalinizing clear cell carcinoma arising on the anterior palatoglossal arch. Anticancer Res. 2007;27(6C):4271–7.

    PubMed  Google Scholar 

  21. Uzochukwu NO, Shrier DA, Lapoint RJ. Clear cell carcinoma of the base of the tongue: MR imaging findings. Am J Neuroradiol. 2007;28:127–8.

    PubMed  CAS  Google Scholar 

  22. Solar AA, Schmidt BL, Jordan RC. Hyalinizing clear cell carcinoma: case series and comprehensive review of the literature. Cancer. 2009;115(1):75–83.

    Article  PubMed  Google Scholar 

  23. Weinreb I, Seethala RR, Perez-Ordoñez B, et al. Oncocytic mucoepidermoid carcinoma: clinicopathologic description in a series of 12 cases. Am J Surgical Pathol. 2009;33(3):410–6.

    Google Scholar 

  24. Maiorano E, Altini M, Favia G. Clear cell tumors of the salivary glands, jaws, and oral mucosa. Semin Diagn Pathol. 1997;14(3):201–12.

    Google Scholar 

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Authors and Affiliations

  1. Virginia Commonwealth University Health System, Richmond, VA, USA

    E. D. O’Sullivan-Mejia, H. D. Massey & C. N. Powers

  2. Massachusetts General Hospital, Boston, MA, USA

    W. C. Faquin

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  1. E. D. O’Sullivan-Mejia
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  2. H. D. Massey
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  3. W. C. Faquin
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  4. C. N. Powers
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Correspondence to E. D. O’Sullivan-Mejia.

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O’Sullivan-Mejia, E.D., Massey, H.D., Faquin, W.C. et al. Hyalinizing Clear Cell Carcinoma: Report of Eight Cases and a Review of Literature. Head and Neck Pathol 3, 179–185 (2009). https://doi.org/10.1007/s12105-009-0124-3

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  • DOI: https://doi.org/10.1007/s12105-009-0124-3

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