Abstract
Objective
To investigate association between vitamin D status and recurrent wheezing in infants.
Methods
Thirty infants with recurrent wheezing and 45 healthy, similar aged infants without any history of acute or chronic illness were included in the study. The clinical features of infants were recorded and serum 25-hydroxyvitamin D [25(OH)D] levels were measured. Data analysis was performed using SPSS 13 package program.
Results
The mean value of 25 (OH) D vitamin levels were 22.1 ± 8.9 IU/L and 18.8 ± 11 IU/L for the control and recurrent attack group respectively. Seventy-three percent of subjects with recurrent wheezing had vitamin D levels in the deficient range (<20 ng/ml) and 48.9 % had vitamin D levels under < 20 ng/ml in the control group. The percentage of insufficient vitamin D levels (<30 ng/ml) were 90 and 77.8 for the patient and control group respectively. Eight patients had extremely deficient vitamin D (<10 ng/ml) levels. There was no statistical significance between the groups in terms of the distribution of 25 (OH)D level.
Conclusions
The present study did not demonstrate significant association between vitamin D status and recurrent wheezing in the infants.
Similar content being viewed by others
References
Black PN, Scragg R. Relationship between serum 25-hydroxyvitamin D and pulmonary function in the third national health and nutrition examination survey. Chest. 2005;128:3792–8.
Hollams EM, Hart PH, Holt BJ, et al. Vitamin D and atopy and asthma phenotypes in children: A longitudinal cohort study. Eur Respir J. 2011;38:1320–7.
Lange NE, Litonjua A, Hawrylowicz CM, Weiss S. Vitamin D, the immune system and asthma. Expert Rev Clin Immunol. 2009;5:693–702.
Liu PT, Stenger S, Tang DH, Modlin RL. Cutting edge: Vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin. J Immunol. 2007;179:2060–3.
Karatekin G, Kaya A, Salihoglu O, Balci H, Nuhoglu A. Association of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers. Eur J Clin Nutr. 2009;63:473–7.
Ginde AA, Mansbach JM, Camargo Jr CA. Vitamin D, respiratory infections and asthma. Curr Allergy Asthma Rep. 2009;9:81–7.
Camargo Jr CA, Rifas-Shiman SL, Litonjua AA, et al. Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 year of age. Am J Clin Nutr. 2007;85:788–95.
Devereux G, Litonjua AA, Turner SW, et al. Maternal vitamin D intake during pregnancy and early childhood wheezing. Am J Clin Nutr. 2007;85:853–9.
Taylor CE, Camargo CA Jr. Impact of micronutrients on respiratory infections. Nutr Rev. 2011;69:259–69.
Sandhu MS, Casale TB. The role of vitamin D in asthma. Ann Allergy Asthma Immunol. 2010;105:191–202.
Majak P, Olszowiec-Chlebna M, Smejda K, Stelmach I. Vitamin D supplementation in children may prevent asthma exacerbation triggered by acute respiratory infection. J Allergy Clin Immunol. 2011;127:1294–6.
Misra M, Pacaud D, Petryk A, et al. Vitamin D deficiency in children and its management: Review of current knowledge and recommendations. Pediatrics. 2008;122:398–417.
Plotkin H, Lifshitz F. Rickets and osteoporosis. In: Lifshitz F, ed. Pediatric Endocrinology, 5th ed, Vol. 2. 5th ed. New York: Informa Healthcare; 2007. pp. 531–57.
Cianferotti L, Marcocci C. Subclinical vitamin D deficiency. Best Pract Res Clin Endocrinol Metabol. 2012;26:523–37.
Binkley N, Ramamurthy R, Krueger D. Low vitamin D status: definition, consequences and correction. Endocrinol Metab Clin N Am. 2010;39:287–301.
Holick MF. Vitamin D, deficiency. N Engl J Med. 2007;357:266–81.
Holick MF, Binkley NC, Bischoff-Ferrari HA, et al., Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911–30.
Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R. Estimates of optimal vitamin D status. Osteoporos Int. 2005;16:713–6.
Vieth R. Why the minimum desirable serum 25-hydroxyvitamin D level should be 75 mol/L (30 ng/ml). Best Pract Res Clin Endocrinol Metabol. 2011;25:681–91.
Nguyen TM, Guillozo H, Marin L, Tordet C, Koite S, Garabedian M. Evidence for a vitamin D paracrine system regulating maturation of developing rat lung epithelium. Am J Physiol. 1996;271:L392–9.
Gaultier C, Harf A, Balmain N, Cuisinier-Gleizes P, Mathieu H. Lung mechanics in rachitic rats. Am Rev Respir Dis. 1984;130:1108–10.
Morales E, Romieu I, Guerra S, et al. Maternal vitamin D status in pregnancy and risk of lower respiratory tract infections, wheezing, and asthma in offspring. Epidemiology. 2012;23:64–71.
Hewison M. Vitamin D, and the immune system: New perspectives on an old theme. Endocrinol Metab Clin N Am. 2010;39:365–79.
Wang TT, Dabbas B, Laperriere D, et al. Direct and indirect induction by 1,25-dihydroxy vitamin D3 of the NOD2/CARD15- defensin beta2 innate immune pathway defective in Crohn disease. J Biol Chem. 2010;285:2227–31.
Janssen R, Bont L, Siezen CL, et al. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. J Infect Dis. 2007;196:826–34.
Roth DE, Jones AB, Prosser C, Robinson JL, Vohra S. Vitamin D receptor polymorphisms and the risk of acute lower respiratory tract infection in early childhood. J Infect Dis. 2008;197:676–80.
Jartti T, Ruuskanen O, Mansbach JM, Vuorinen T, Camargo CA Jr. Low serum 25-hydroxyvitamin D levels are associated with increased risk of viral coinfections in wheezing children. J Allergy Clin Immunol. 2010;126:1074–6.
Bosse Y, Maghni K, Hudson TJ. 1α,25-dihidroxy-vitamin D3 stimulation of bronchial smooth muscle cells induces autocrine, contractility and remodeling processes. Physiol Genomics. 2007;29:161–8.
Brehm JM, Celedon JC, Soto-Quiros ME, et al. Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica. Am J Res Crit Care Med. 2009;179:765–71.
Conflict of Interest
None.
Role of Funding Source
None.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Özaydın, E., Bütün, M.F., Çakır, B.Ç. et al. The Association Between Vitamin D Status and Recurrent Wheezing. Indian J Pediatr 80, 907–910 (2013). https://doi.org/10.1007/s12098-013-1005-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12098-013-1005-z