Skip to main content

Advertisement

SpringerLink
Log in

Clinicohematological study of thrombocytosis

  • Original Article
  • Published:
The Indian Journal of Pediatrics Aims and scope Submit manuscript

Abstract

Objective

To find out etiology and clinical course of thrombocytosis in Indian pediatric population.

Methods

A total of 250 patients having thrombocytosis (defined as platelet count >500 × 109/L) on haematological investigations were studied over one yr period. All patients were evaluated clinically and were subjected to investigations, including complete blood counts (CBC) with peripheral smear examination. To elucidate the possible role of inflammatory cytokines in pathogenesis of RT, levels of Interleukin-6 (IL-6) and C — reactive protein (CRP) were estimated.

Results

Infants and young children (<2 yr age) were most common group, contributing 60% of total cases. Out of total 250 cases, only 3 (1.2%) cases were found to have primary thrombocytosis and remaining 98.8% cases were having RT. Among RT patients, infections (alone or in association with iron deficiency anemia) were most common cause, accounting for 65% cases, while iron deficiency anemia (IDA) was second most common cause accounting for 41.3% cases (12.6% IDA alone and 28.7 % in association with infections). Other causes included nutritional dimorphic anemia and patients on treatment for megaloblastic anemia, acute lymphoblastic leukemia (during treatment) and lymphoma. Among various groups of RT, IL-6 and CRP levels were higher in patients with infection with or without IDA than IDA alone. One child with essential thrombocytosis and one child with RT had thrombotic complications. On follow up, platelet counts normalized in most of the patients with treatment of underlying conditions.

Conclusions

Results of this study suggest that essential thrombocytosis is extremely rare in children. Infections and IDA (alone or in association with infections) are common causes of RT. IL-6 and CRP levels are increased in patients with RT, to a higher level in patients with infections than in patients with IDA. Most patients with RT have uneventful recovery of platelet counts to normal range with treatment for underlying condition.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Dame C, Sutor AH. Primary and secondary thrombocytosis in childhood. Br J Haematol 2005; 129: 165–177.

    Article  CAS  PubMed  Google Scholar 

  2. Schafer AI. Thrombocytosis. New Engl J Med 2004; 350: 1211–1219.

    Article  CAS  PubMed  Google Scholar 

  3. Maguire JL, deVeber G, Parkin PC. Association between iron-deficiency anemia and stroke in young children. Pediatrics 2007; 120: 1053–1057.

    Article  PubMed  Google Scholar 

  4. Akins PT, Glenn S, Nemeth PM, Derdeyn CP. Carotid artery thrombus associated with severe iron-deficiency anemia and thrombocytosis. Stroke 1996; 27: 1002–1005.

    CAS  PubMed  Google Scholar 

  5. Belman AL, Roque CT, Ancona R, Anand AK, Davis RP. Cerebral venous thrombosis in a child with iron deficiency anemia and thrombocytosis. Stroke 1990; 21: 488–493.

    CAS  PubMed  Google Scholar 

  6. Sebire G, Tabarki B, Saunders DE, Leroy I, Leisner R, Martin SC, Husson B et al. Cerebral venous sinus thrombosis in children: risk factors, presentation, diagnosis and outcome. Brain 2005; 128: 477–489.

    Article  CAS  PubMed  Google Scholar 

  7. Hollen CW, Henthorn J, Koziol JA, Burstein SA. Elevated serum interleukin-6 levels in patients with reactive thrombocytosis. Br J Haematol 1991; 79: 286–290.

    Article  CAS  PubMed  Google Scholar 

  8. Tefferi A, Ho TC, Ahmann GJ, Katzmann JA, Greipp PR. Plasma interleukin-6 and C-reactive protein levels in reactive versus clonal thrombocytosis. Am J Med 1994; 94: 374–378.

    Article  Google Scholar 

  9. Matsubara K, Fukaya T, Nigami H, Harigaya H, Hirata T, Nozaki H, baba K. Age-dependent changes in the incidence and etiology of childhood thrombocytosis. Acta Haematol 2004; 111: 132–137.

    Article  PubMed  Google Scholar 

  10. Chan KW, Kaikov Y, Wadsworth LD. Thrombocytosis in childhood: A survey of 94 patients. Pediatrics 1989; 84: 1064–1067.

    CAS  PubMed  Google Scholar 

  11. Vora AJ, Lilleyman JS. Secondary thrombocytosis. Arch Dis Child 1993; 68: 88–90.

    Article  CAS  PubMed  Google Scholar 

  12. Yohannan MD, Higgy KE, Al-Mashhadani SA, Santhosh-Kumar CR. Thrombocytosis: Etiologic analysis of 663 patients. Clinic Pediatr 1994; 33: 340–343.

    Article  CAS  Google Scholar 

  13. Gomber S, Kumar S, Rusia U, Gupta P, Agarwal KN, Sharma S. Prevalence and etiology of nutritional anemias in early childhood in an urban slum. Indian J Med Res 1998; 107: 269–273.

    CAS  PubMed  Google Scholar 

  14. Lipschitz DA, Cook JD, Finch CA. A Clinical evaluation of serum ferritin as an index of iron stores. New Engl J Med 1974; 290: 1213.

    CAS  PubMed  Google Scholar 

  15. National Family Health Survey-3, 2005–2006. International Institute of Population Sciences, Mumbai 2005.

  16. Bilic E. Amino acid sequence homology of thrombopoietin and erythropoietin may explain thrombocytosis in children with iron deficiency anemia. J Pediatr Hematol Oncol 2003; 25: 675–676.

    Article  PubMed  Google Scholar 

  17. Chandra J, Jain V, Narayan S et al. Tremors and thrombocytosis during treatment of megaloblastic anemia. Annals Trop Pediatr 2006; 26: 101–105.

    Article  Google Scholar 

  18. Randi ML, Rossi C, Barbonr E, Pietrogrande F, Girolami A. Incidence of thrombocytosis in lymphomas. Leuk Lymphoma 1992; 7: 139–141.

    Article  CAS  PubMed  Google Scholar 

  19. Ishiguro A, Suzuki Y, Mito M et al. Elevation of serum thrombopoietin precedes thrombocytosis in acute infections. Br J Haematol 2002; 116: 612–618.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, Lady Hardinge Medical College and Associated Kalawati Saran, Children’s Hospital, New Delhi, India

    Dinesh Yadav, Jagdish Chandra & Varinder Singh

  2. Department of Pathology, Lady Hardinge Medical College and Associated Kalawati Saran, Children’s Hospital, New Delhi, India

    Sunita Sharma

  3. Lady Hardinge Medical College, Lecturer’s Flat No 5, New Delhi, 110001, India

    Jagdish Chandra

Authors
  1. Dinesh Yadav
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jagdish Chandra
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sunita Sharma
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Varinder Singh
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jagdish Chandra.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yadav, D., Chandra, J., Sharma, S. et al. Clinicohematological study of thrombocytosis. Indian J Pediatr 77, 643–647 (2010). https://doi.org/10.1007/s12098-010-0091-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12098-010-0091-4

Key words

Search

Navigation