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The dissociation between the diabetes and both Child–Pugh score and in-hospital mortality in cirrhotic patients due to hepatitis B, hepatitis C, or alcoholic

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Abstract

Background

Up to 30% of the cirrhotic patients may clinically be classified as having diabetes. The aims of this retrospective study were to evaluate the prevalence of diabetes, its association with the severity of cirrhosis, and subsequent implication on mortality in a broad population of cirrhotic patients in Taiwan.

Methods

From January 2004 to October 2008, 4,127 cirrhotic patients were reviewed. The latest demographic data were gathered after the latest laboratory measurement in the outpatient or inpatient department. In all, 2,945 patients were included on the basis of the etiology of cirrhosis: hepatitis B, hepatitis C, hepatitis B, and hepatitis C co-infection, or alcoholics.

Results

The observed cases of diabetes were significantly higher in cirrhotic patients than general population. Neither the Child–Pugh score (odds ratio = 0.99, p = 0.527) nor the model for end-stage liver disease score (MELD) (odds ratio = 1.00, p = 0.352) was associated with diabetes. The presence of diabetes was dissociated with renal function by means of serum creatinine (β = −0.01, p = 0.604) or estimated glomerular filtration rate (eGFR) (β = −0.02, p = 0.233), or in-hospital mortality (odds ratio = 1.08, p = 0.362).

Conclusion

The prevalence of diabetes was higher in cirrhotic patients in Taiwan. The prevalence of diabetes was dissociated with Child–Pugh or MELD score. The diagnosis of diabetes did not affect the renal function or in-hospital mortality in cirrhotic patients. Since the clinical outcomes of diabetes were different from cirrhotic patients to general population, it is unclear whether the treatment of diabetes and improved glycemic control will benefit cirrhotic patients.

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Authors and Affiliations

  1. Division of Nephrology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan

    Yu-Wei Chen, Han-Hsiang Chen & Chih-Jen Wu

  2. Division of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan

    Tsang-En Wang, Ching-Wei Chang & Chen-Wang Chang

  3. Division of Endocrinology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan

    Wei-Che Chen

  4. Mackay Medicine, Nursing and Management College, Taipei, Taiwan

    Yu-Wei Chen, Han-Hsiang Chen, Tsang-En Wang, Ching-Wei Chang, Chen-Wang Chang, Wei-Che Chen & Chih-Jen Wu

  5. National Taipei College of Nursing, Taipei, Taiwan

    Han-Hsiang Chen

  6. Graduate Institute of Medical Science, Taipei Medical University, Taipei, Taiwan

    Chih-Jen Wu

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  1. Yu-Wei Chen
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Correspondence to Chih-Jen Wu.

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Chen, YW., Chen, HH., Wang, TE. et al. The dissociation between the diabetes and both Child–Pugh score and in-hospital mortality in cirrhotic patients due to hepatitis B, hepatitis C, or alcoholic. Hepatol Int 5, 955–964 (2011). https://doi.org/10.1007/s12072-011-9274-y

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  • DOI: https://doi.org/10.1007/s12072-011-9274-y

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