Abstract
Hypertension is one of the leading causes of disability or death due to stroke, heart attack and kidney failure. Because the etiology of essential hypertension is not known and may be multifactorial, the use of experimental animal models has provided valuable information regarding many aspects of the disease, which include etiology, pathophysiology, complications and treatment. The models of hypertension are various, and in this review, we provide a brief overview of the most widely used animal models, their features and their importance.
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Abbreviations
- ANG II:
-
angiotensin II
- BHR:
-
borderline hypertensive rat
- CBF:
-
cerebral blood flow
- DOCA:
-
11-desoxycorticosterone acetate
- DR:
-
Dahl salt-resistant rat
- DS:
-
Dahl salt-sensitive rat
- EDCF:
-
endothelium-derived constricting factor
- EDRF:
-
endothelium-derived relaxing factor
- HR:
-
heart rate
- LV:
-
left ventricle
- MAP:
-
mean arterial pressure
- PRA:
-
plasma rennin activity
- RAAS:
-
rennin–angiotensin–aldosterone system
- ROS:
-
reactive oxygen species
- RSNA:
-
renal sympathetic nerve activity
- SAD:
-
sinoaortic baroreceptors
- SHR:
-
spontaneously hypertensive rat
- SHRSP:
-
stroke-prone spontaneously hypertensive rat
- SOD:
-
superoxide dismutase
- WKY:
-
Wistar–Kyoto
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We are grateful to Dr Rinaldo Cardoso dos Santos for his critical reading of the manuscript.
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ePublication: 16 August 2011
[Dornas WC and Silva ME 2011 Animal models for the study of arterial hypertension. J. Biosci. 36 731–737] DOI 10.1007/s12038-011-9097-y
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Dornas, W.C., Silva, M.E. Animal models for the study of arterial hypertension. J Biosci 36, 731–737 (2011). https://doi.org/10.1007/s12038-011-9097-y
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DOI: https://doi.org/10.1007/s12038-011-9097-y