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Delayed response and survival from NovoTTF-100A in recurrent GBM

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Abstract

We present a 48-year-old male with recurrent glioblastoma (GBM) who was enrolled in the NovoTTF-100A landmark phase III study and has been on device for >6 years. During this time, his magnetic resonance images demonstrated initial growth followed by a slow decrease in enhancement with continued residual disease. Long-term survivors in patients with recurrent GBM are rare, especially in the absence of definitive local treatment such as surgery or radiosurgery. We present the clinical, imaging and pathological findings for this patient in relation to use of the NovoTTF-100A device.

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Acknowledgments

Authors received fund from Novocure clinical trial sponsorship.

Conflict of interest

None.

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Authors and Affiliations

  1. Department of Medicine, University of Illinois Medical Center, Chicago, IL, USA

    J. Lee Villano & Nandini Ignatius

  2. Department of Neurosurgery, University of Illinois Medical Center, Chicago, IL, USA

    J. Lee Villano, Leena E. Williams, Karriem S. Watson & Herbert H. Engelhard

  3. Department of Neurology, University of Illinois Medical Center, Chicago, IL, USA

    Marquess T. Wilson

  4. Department of Pathology, University of Illinois Medical Center, Chicago, IL, USA

    Tibor Valyi-Nagy

  5. Department of Radiology, University of Illinois Medical Center, Chicago, IL, USA

    Edward A. Michals

  6. University of Kentucky, 800 Rose St., CC447, Lexington, KY, 40536-0093, USA

    J. Lee Villano

Authors
  1. J. Lee Villano
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  2. Leena E. Williams
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  3. Karriem S. Watson
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  4. Nandini Ignatius
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  5. Marquess T. Wilson
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  6. Tibor Valyi-Nagy
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  7. Edward A. Michals
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  8. Herbert H. Engelhard
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Correspondence to J. Lee Villano.

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Villano, J.L., Williams, L.E., Watson, K.S. et al. Delayed response and survival from NovoTTF-100A in recurrent GBM. Med Oncol 30, 338 (2013). https://doi.org/10.1007/s12032-012-0338-1

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  • DOI: https://doi.org/10.1007/s12032-012-0338-1

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