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Clinical features of the most common fusion genes in childhood acute lymphoblastic leukemia

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Abstract

Contemporary protocols ensure high-remission rate and long-term free survival in children with acute lymphoblastic leukemia (ALL), but small percentage of patients is still incurable. Molecular genetic methods helped to establish submicroscopic classification as well as minimal residual disease follow-up, considered to be responsible for relapse. Our study enrolled 70 pediatric patients with de novo ALL, analyzed using reverse transcriptase-polymerase chain reaction for the presence of four major risk-stratifying translocations (BCR/ABL, MLL/AF4, TEL/AML1, and E2A/PBX1). Bone marrow samples were collected at diagnosis, at the end of induction phase, and after intensive chemotherapy with the aim to establish the correlation between chromosomal aberration, clinical features, and treatment response. Presenting the results of this study, we offer another evidence of variable incidence and clinical characteristics of ALL subtypes.

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Acknowledgments

This work was supported by Ministry of Science, Republic of Serbia (Grant No. 143051).

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Authors and Affiliations

  1. Department for Hematology and Oncology, University Children’s Hospital, Tirsova 10, 11000, Belgrade, Serbia

    J. Lazic, L. Dokmanovic, N. Krstovski, P. Rodic & D. Janic

  2. Laboratory for Molecular Hematology, Institute for Molecular Genetics and Molecular Engineering, Vojvode Stepe 444b, 11000, Belgrade, Serbia

    N. Tosic & S. Pavlovic

Authors
  1. J. Lazic
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  2. N. Tosic
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  3. L. Dokmanovic
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  4. N. Krstovski
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  5. P. Rodic
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  6. S. Pavlovic
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  7. D. Janic
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Correspondence to D. Janic.

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J. Lazic and N. Tosic equally contributed to the manuscript.

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Lazic, J., Tosic, N., Dokmanovic, L. et al. Clinical features of the most common fusion genes in childhood acute lymphoblastic leukemia. Med Oncol 27, 449–453 (2010). https://doi.org/10.1007/s12032-009-9232-x

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  • DOI: https://doi.org/10.1007/s12032-009-9232-x

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