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CSF Catecholamine Profile in Subarachnoid Hemorrhage Patients with Neurogenic Cardiomyopathy

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Abstract

Background

Patients experiencing apoplectic intracranial processes may develop neurogenic cardiomyopathy (NC). The purpose of this research is to determine whether cerebrospinal fluid (CSF) catecholamine levels are elevated in subarachnoid hemorrhage (SAH) patients with NC when compared to those without NC.

Methods

Observational study of consecutive grades 3–5 SAH patients requiring ventriculostomy. All patients underwent CSF sampling for catecholamine levels, and transthoracic echocardiography (TTE) to assess for NC, within 48 h of SAH onset. Univariate analyses were performed to identify clinical and laboratory variables associated with NC. Clinical variables associated with NC in the univaritate analysis were entered into logistic regression models along with the candidate catecholamine variables to identify predictors of NC.

Results

The study group contained 100 patients—mean age of study subjects was 58 years, 73% were female, and 15% developed NC. NC patients were more likely to have a worse clinical grade than patients without NC (80 vs. 34%, P = 0.001). NC patients possessed greater DOPA levels (5.83 vs. 4.60 nmol/l, P = 0.044), and a trend toward greater noradrenergic activity as determined by NE/DHPG ratio (0.3799 vs. 0.2519, P = 0.073). Multivariate analysis identified worse clinical grade (OR 7.09, P = 0.005) and possibly NE levels (OR 1.005, P = 0.057) as independent predictors of NC. Bivariate analysis reinforced the findings for NE (OR 1.006, P = 0.022), and also identified DOPA levels (OR 1.001, P = 0.034) and NE/DHPG (OR 22.18, P = 0.019) as predictors of NC.

Conclusions

SAH patients with NC tend to have greater CSF catecholamine levels than those without NC. However, the development of NC may also be related to factors not evaluated by our study.

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Acknowledgments

The authors express gratitude to the nurses of the neurological intensive care unit from the Jefferson Hospital of Neurosciences at Thomas Jefferson University Medical Center for their assistance in this project. This research study was supported in part by the Intramural Research Program of the NIH/NICHD.

Conflict of interest

The authors have no financial interests or conflicts of interest to announce.

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Authors and Affiliations

  1. Cerebrovascular and Neurocritical Care Division, Thomas Jefferson Medical Center, 900 Walnut Street, Suite 200, Philadelphia, PA, 19107, USA

    Michael Moussouttas

  2. Section on Medical Neuroendocrinology, Reproductive and Adult Endocrinology Program, National Institutes of Health, Bethesda, MD, USA

    Edwin W. Lai, Thanh T. Huynh, Gilberto Carmona & Karel Pacak

  3. Department of Neurology, Thomas Jefferson Medical Center, Philadelphia, PA, USA

    Keith Dombrowski & John Khoury

  4. Department of Medicine, Thomas Jefferson Medical Center, Philadelphia, PA, USA

    Matthew DeCaro

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  1. Michael Moussouttas
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  2. Edwin W. Lai
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  4. Thanh T. Huynh
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  5. John Khoury
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  6. Gilberto Carmona
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Corresponding author

Correspondence to Michael Moussouttas.

Additional information

Collaborating Institutions: This project represents a collaboration between the Neurocritical Care Division and Department of Cardiology at Thomas Jefferson Medical Center, and the Section on Neuroendocrinology of the Reproductive and Adult Endocrinology Program at the National Institutes of Health.

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Moussouttas, M., Lai, E.W., Dombrowski, K. et al. CSF Catecholamine Profile in Subarachnoid Hemorrhage Patients with Neurogenic Cardiomyopathy. Neurocrit Care 14, 401–406 (2011). https://doi.org/10.1007/s12028-011-9527-6

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  • DOI: https://doi.org/10.1007/s12028-011-9527-6

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