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Toll-like receptors and B cells: functions and mechanisms

  • IMMUNOLOGY AT THE UNIVERSITY OF IOWA
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Abstract

Numerous reports have described Toll-like receptor (TLR) functions in myeloid cells such as dendritic cells (DCs) and macrophages, but relatively fewer studies have examined TLR responses in B lymphocytes. B cells express a wide variety of TLRs and are highly activated after TLR ligation, leading to enhancements in B cell survival, surface molecule expression, cytokine and antibody production, and antigen presentation. During an immune response, B cells can receive signals through TLRs as well as the B cell antigen receptor (BCR) and/or CD40. TLR ligation synergizes with signals through these receptors and augments both innate and adaptive immune functions of B lymphocytes. Additionally, targeting B cell TLRs may provide new therapies against certain types of cancer as well as autoimmune diseases. Here, we summarize TLR expression and contributions to both normal and pathogenic functions in mouse and human B cells.

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Authors and Affiliations

  1. Graduate Program in Immunology, University of Iowa, Iowa City, IA, 52242, USA

    Claire M. Buchta & Gail A. Bishop

  2. Department of Microbiology, University of Iowa, Iowa City, IA, 52242, USA

    Gail A. Bishop

  3. Department of Internal Medicine, University of Iowa, Iowa City, IA, 52242, USA

    Gail A. Bishop

  4. Iowa City Veterans Affairs Medical Center, Iowa City, IA, 52242, USA

    Gail A. Bishop

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  1. Claire M. Buchta
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Buchta, C.M., Bishop, G.A. Toll-like receptors and B cells: functions and mechanisms. Immunol Res 59, 12–22 (2014). https://doi.org/10.1007/s12026-014-8523-2

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