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Mechanisms involved in antibody- and complement-mediated allograft rejection

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Abstract

Antibody-mediated rejection has become critical clinically because this form of rejection is usually unresponsive to conventional anti-rejection therapy, and therefore, it has been recognized as a major cause of allograft loss. Our group developed experimental animal models of vascularized organ transplantation to study pathogenesis of antibody- and complement-mediated endothelial cell injury leading to graft rejection. In this review, we discuss mechanisms of antibody-mediated graft rejection resulting from activation of complement by C1q- and MBL (mannose-binding lectin)-dependent pathways and interactions with a variety of effector cells, including macrophages and monocytes through Fcγ receptors and complement receptors.

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Acknowledgments

The author would like to thank Dr. William M. Baldwin, III for critical review of the manuscript and help with the preparation of Fig. 1, and Dr. Joan Glick Bieler for the help with the editing of the manuscript. The author was supported by grants: NIH R01-HL63948, American Heart Association Grant-in-Aid, Roche Organ Transplantation Research Foundation (ROTRF) grants ID#508303540 and #513443778, Talecris Biotherapeutics, Inc., Talent Program grant.

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  1. Department of Pathology, The Johns Hopkins University School of Medicine, 720 Rutland Ave., Ross Bldg. 664B, Baltimore, MD, 21205, USA

    Barbara A. Wasowska

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Wasowska, B.A. Mechanisms involved in antibody- and complement-mediated allograft rejection. Immunol Res 47, 25–44 (2010). https://doi.org/10.1007/s12026-009-8136-3

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