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Allergic and Immunologic Reactions to Food Additives

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Abstract

For centuries, food additives have been used for flavouring, colouring and extension of the useful shelf life of food, as well as the promotion of food safety. During the last 20 years, the studies implicating the additives contained in foods and medicine as a causative factor of allergic reactions have been proliferated considerably. In this review, we aimed to overview all of the food additives which were approved to consume in EU and find out how common and serious allergic reactions come into existence following the consuming of food additives.

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References

  1. Emerton V, Choi E (2008) Chapter 1: Food additives and why they are used. In: Leatherhead Food International (ed) Essential guide to food additives, 3rd edn. RSC, Cambridge, pp 1–11

    Chapter  Google Scholar 

  2. Jones SM, Burks AW (2008) Part 2: Adverse reactions to food antigens: clinical science. Chapter 8: The spectrum of allergic reactions to foods. In: Metcalfe DD, Sampson HA, Simon RA (eds) Food allergy adverse reactions to foods and food additives, 4th edn. Blackwell, Melbourne, p 101

    Google Scholar 

  3. Rona RJ, Keil T, Summers C, Gislason D, Zuidmeer L, Sodergren E, Sigurdardottir ST, Lindner T, Goldhahn K, Dahlstrom J, McBride D, Madsen C (2007) The prevalence of food allergy: a meta-analysis. J Allergy Clin Immunol 120(3):638–646

    Article  PubMed  Google Scholar 

  4. Wüthrich B (1993) Adverse reactions to food additives. Ann Allergy 71(4):379–384

    PubMed  Google Scholar 

  5. Reus KE, Houben GF, Stam M, Dubois AE (2000) Food additives as a cause of medical symptoms: relationship shown between sulfites and asthma and anaphylaxis; results of a literature review. Ned Tijdschr Geneeskd 144(38):1836–1839

    PubMed  CAS  Google Scholar 

  6. Goodman DL, McDonnell JT, Nelson HS, Vaughan TR, Weber RW (1990) Chronic urticaria exacerbated by the antioxidant food preservatives, butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT). J Allergy Clin Immunol 86(4 Pt 1):570–575

    Article  PubMed  CAS  Google Scholar 

  7. Orton DI, Shaw S (2001) Allergic contact dermatitis from pharmaceutical grade BHA in Timodine, with no patch test reaction to analytical grade BHA. Contact Dermatitis 44(3):191–192

    Article  PubMed  CAS  Google Scholar 

  8. Yamaki K, Taneda S, Yanagisawa R, Inoue K, Takano H, Yoshino S (2007) Enhancement of allergic responses in vivo and in vitro by butylated hydroxytoluene. Toxicol Appl Pharmacol 223(2):164–172

    Article  PubMed  CAS  Google Scholar 

  9. Le Coz CJ, Schneider GA (1998) Contact dermatitis from tertiary-butylhydroquinone in a hair dye, with cross-sensitivity to BHA and BHT. Contact Dermatitis 39(1):39–40

    Article  PubMed  Google Scholar 

  10. White IR, Lovell CR, Cronin E (1984) Antioxidants in cosmetics. Contact Dermatitis 11(5):265–267

    Article  PubMed  CAS  Google Scholar 

  11. García-Melgares ML, de la Cuadra J, Martín B, Laguna C, Martínez L, Alegre V (2007) Sensitization to gallates: review of 46 cases. Actas Dermosifiliogr 98(10):688–693

    Article  PubMed  Google Scholar 

  12. Lomaga MA, Polak S, Grushka M, Walsh S (2009) Results of patch testing in patients diagnosed with oral lichen planus. J Cutan Med Surg 13(2):88–95

    PubMed  Google Scholar 

  13. Igoe RS (2011) Part I: Ingredients dictionary. In: Dictionary of food ingredients, 5th edn. Springer, Berlin

  14. Young E, Patel S, Stoneham M, Rona R, Wilkinson JD (1987) The prevalence of reaction to food additives in a survey population. J R Coll Physicians Lond 21(4):241–247

    PubMed  CAS  Google Scholar 

  15. Hannuksela M, Haahtela T (1987) Hypersensitivity reactions to food additives. Allergy 42(8):561–575

    Article  PubMed  CAS  Google Scholar 

  16. Fuglsang G, Madsen C, Saval P, Osterballe O (1993) Prevalence of intolerance to food additives among Danish school children. Pediatr Allergy Immunol 4(3):123–129

    Article  PubMed  CAS  Google Scholar 

  17. Keil H (1962) Group reactions in contact dermatitis due to resorcinol. Arch Dermatol 86:212–216

    Article  PubMed  CAS  Google Scholar 

  18. Burrows D, Irvine J (1982) Contact dermatitis to hexylresorcinol. Contact Dermatitis 8(1):71

    Article  PubMed  CAS  Google Scholar 

  19. Greenhawt M, Baldwin JL (2008) Part 4: Adverse reactions to food additives. Chapter 34: Food colorings and flavors. In: Metcalfe DD, Sampson HA, Simon RA (eds) Food allergy adverse reactions to foods and food additives. Blackwell, Melbourne, pp 403–428

    Google Scholar 

  20. Lucas CD, Hallagan JB, Taylor SL (2001) The role of natural color additives in food allergy. Adv Food Nutr Res 43:195–216

    Article  PubMed  CAS  Google Scholar 

  21. Ebo DG, Ingelbrecht S, Bridts CH, Stevens WJ (2009) Allergy for cheese: evidence for an IgE-mediated reaction from the natural dye annatto. Allergy 64(10):1558–1560

    Article  PubMed  CAS  Google Scholar 

  22. Nish WA, Whisman BA, Goetz DW, Ramirez DA (1991) Anaphylaxis to annatto dye: a case report. Ann Allergy 66(2):129–131

    PubMed  CAS  Google Scholar 

  23. Mikkelsen H, Larsen JC, Tarding F (1978) Hypersensitivity reactions to food colours with special reference to the natural colour annatto extract (butter colour). Arch Toxicol Suppl (1):141–143

  24. Juhlin L (1981) Recurrent urticaria: clinical investigation of 330 patients. Br J Dermatol 104(4):369–381

    Article  PubMed  CAS  Google Scholar 

  25. Stein HL (2009) Annatto and IBS. J Clin Gastroenterol 43(10):1014–1015

    Article  PubMed  Google Scholar 

  26. Gousse AE, Safir MH, Madjar S, Ziadlourad F, Raz S (2000) Life-threatening anaphylactoid reaction associated with indigo carmine intravenous injection. Urology 56(3):508

    Article  PubMed  CAS  Google Scholar 

  27. Naitoh J, Fox BM (1994) Severe hypotension, bronchospasm, and urticaria from intravenous indigo carmine. Urology 44(2):271–272

    Article  PubMed  CAS  Google Scholar 

  28. Graziano S, Hoyte L, Vilich F, Brubaker L (2005) Life-threatening reaction to indigo carmine—a sulfa allergy? Int Urogynecol J Pelvic Floor Dysfunct 16(5):418–419

    Article  PubMed  Google Scholar 

  29. Miller ME, Lummus ZL, Bernstein DI (1996) Occupational asthma caused by FD&C blue dye no. 2. Allergy Asthma Proc 17(1):31–34

    Article  PubMed  CAS  Google Scholar 

  30. Magner J, Gerber P (1994) Urticaria due to blue dye in synthroid tablets. Thyroid 4(3):341

    Article  PubMed  CAS  Google Scholar 

  31. Acero S, Tabar AI, Alvarez MJ, Garcia BE, Olaguibel JM, Moneo I (1998) Occupational asthma and food allergy due to carmine. Allergy 53(9):897–901

    Article  PubMed  CAS  Google Scholar 

  32. Lizaso MT, Moneo I, García BE, Acero S, Quirce S, Tabar AI (2000) Identification of allergens involved in occupational asthma due to carmine dye. Ann Allergy Asthma Immunol 84(5):549–552

    Article  PubMed  CAS  Google Scholar 

  33. Tabar AI, Acero S, Arregui C, Urdánoz M, Quirce S (2003) Asthma and allergy due to carmine dye. An Sist Sanit Navar 26(Suppl 2):65–73

    PubMed  Google Scholar 

  34. Tabar-Purroy AI, Alvarez-Puebla MJ, Acero-Sainz S, García-Figueroa BE, Echechipía-Madoz S, Olaguibel-Rivera JM, Quirce-Gancedo SJ (2003) Carmine (E-120)-induced occupational asthma revisited. Allergy Clin Immunol 111(2):415–419

    Article  CAS  Google Scholar 

  35. Ferrer A, Marco FM, Andreu C, Sempere JM (2005) Occupational asthma to carmine in a butcher. Int Arch Allergy Immunol 138(3):243–250

    Article  PubMed  Google Scholar 

  36. Añíbarro B, Seoane J, Vila C, Múgica V, Lombardero M (2003) Occupational asthma induced by inhaled carmine among butchers. Int J Occup Med Environ Health 16(2):133–137

    PubMed  Google Scholar 

  37. Beaudouin E, Kanny G, Lambert H, Fremont S, Moneret-Vautrin DA (1995) Food anaphylaxis following ingestion of carmine. Ann Allergy Asthma Immunol 74(5):427–430

    PubMed  CAS  Google Scholar 

  38. Kotobuki Y, Azukizawa H, Nishida Y, Murota H, Katayama I, Yoshikawa K (2007) Case of urticaria due to cochineal dye in red-colored diet. Arerugi 56(12):1510–1514

    PubMed  Google Scholar 

  39. Zenaidi M, Pauliat S, Chaliier P, Fratta A, Girardet JP (2005) Allergy to food colouring. A prospective study in ten children. Tunis Med 83(7):414–418

    PubMed  Google Scholar 

  40. Yamakawa Y, Oosuna H, Yamakawa T, Aihara M, Ikezawa Z (2009) Cochineal extract-induced immediate allergy. J Dermatol 36(1):72–74

    Article  PubMed  Google Scholar 

  41. Wüthrich B, Kägi MK, Stücker W (1997) Anaphylactic reactions to ingested carmine (E120). Allergy 52(11):1133–1137

    Article  PubMed  Google Scholar 

  42. Greenhawt M, McMorris M, Baldwin J (2009) Carmine hypersensitivity masquerading as azithromycin hypersensitivity. Allergy Asthma Proc 30(1):95–101

    Article  PubMed  CAS  Google Scholar 

  43. Shaw DW (2009) Allergic contact dermatitis from carmine. Dermatitis 20(5):292–295

    PubMed  Google Scholar 

  44. Greenhawt MJ, Baldwin JL (2009) Carmine dye and cochineal extract: hidden allergens no more. Ann Allergy Asthma Immunol 103(1):73–75

    Article  PubMed  CAS  Google Scholar 

  45. Kägi MK, Wüthrich B, Johansson SG (1994) Campari-Orange anaphylaxis due to carmine allergy. Lancet 344(8914):60–61

    Article  PubMed  Google Scholar 

  46. DiCello MC, Myc A, Baker JR Jr, Baldwin JL (1999) Anaphylaxis after ingestion of carmine colored foods: two case reports and a review of the literature. Allergy Asthma Proc 20(6):377–382

    Article  PubMed  CAS  Google Scholar 

  47. Chung K, Baker JR Jr, Baldwin JL, Chou A (2001) Identification of carmine allergens among three carmine allergy patients. Allergy 56(1):73–77

    Article  PubMed  CAS  Google Scholar 

  48. Ohgiya Y, Arakawa F, Akiyama H, Yoshioka Y, Hayashi Y, Sakai S, Ito S, Yamakawa Y, Ohgiya S, Ikezawa Z, Teshima R (2009) Molecular cloning, expression, and characterization of a major 38-kd cochineal allergen. J Allergy Clin Immunol 123(5):1157–1162

    Article  PubMed  CAS  Google Scholar 

  49. Guy C, Dzviga C, Genot A, Patural P, Ollagnier M (1995) Hypersensitivity to Sintrom, caused by cochineal red A. Therapie 50(5):483–484

    PubMed  CAS  Google Scholar 

  50. Ibero M, Eseverri JL, Barroso C, Botey J (1982) Dyes, preservatives and salicylates in the induction of food intolerance and/or hypersensitivity in children. Allergol Immunopathol 10(4):263–268

    CAS  Google Scholar 

  51. Veien NK, Krogdahl A (1991) Cutaneous vasculitis induced by food additives. Acta Derm Venereol 71(1):73–74

    PubMed  CAS  Google Scholar 

  52. Elhkim MO, Héraud F, Bemrah N, Gauchard F, Lorino T, Lambré C, Frémy JM, Poul JM (2007) New considerations regarding the risk assessment on tartrazine—an update toxicological assessment, intolerance reactions and maximum theoretical daily intake in France. Regul Toxicol Pharmacol 47(3):308–316

    Article  PubMed  CAS  Google Scholar 

  53. Virchow C, Szczeklik A, Bianco S (1988) Intolerance to tartrazine in aspirin-induced asthma: results of multicenter study. Respiration 53:20–23

    Article  PubMed  CAS  Google Scholar 

  54. Nettis E, Colanardi MC, Ferrannini A, Tursi A (2003) Suspected tartrazine-induced acute urticaria/angioedema is only rarely reproducible by oral rechallenge. Clin Exp Allergy 33:1725–1729

    Article  PubMed  CAS  Google Scholar 

  55. Pestana S, Moreira M, Olej B (2010) Safety of ingestion of yellow tartrazine by double-blind placebo controlled challenge in 26 atopic adults. Allergol Immunopathol 38(3):142–146

    Article  CAS  Google Scholar 

  56. Pacor ML, Di Lorenzo G, Martinelli N, Mansueto P, Rini GB, Corrocher R (2004) Monosodium benzoate hypersensitivity in subjects with persistent rhinitis. Allergy 59(2):192–197

    Article  PubMed  CAS  Google Scholar 

  57. Sakakibara H, Suetsugu S (1995) Aspirin-induced asthma as an important type of bronchial asthma. Nihon Kyobu Shikkan Gakkai Zasshi Suppl 33:106–115

    Google Scholar 

  58. Ardern KD, Ram FS (2001) Tartrazine exclusion for allergic asthma. Cochrane Database Syst Rev (4):CD000460.

  59. Devlin J, David TJ (1992) Tartrazine in atopic eczema. Arch Dis Child 67(6):709–711

    Article  PubMed  CAS  Google Scholar 

  60. Van Bever HP, Docx M, Stevens WJ (1989) Food and food additives in severe atopic dermatitis. Allergy 44(8):588–594

    Article  PubMed  Google Scholar 

  61. Orchard DC, Varigos GA (1997) Fixed drug eruption to tartrazine. Australas J Dermatol 38(4):212–214

    Article  PubMed  CAS  Google Scholar 

  62. Bhatia MS (2000) Allergy to tartrazine in psychotropic drugs. J Clin Psychiatry 61(7):473–476

    Article  PubMed  CAS  Google Scholar 

  63. Inomata N, Osuna H, Fujita H, Ogawa T, Ikezawa Z (2006) Multiple chemical sensitivities following intolerance to azo dye in sweets in a 5-year-old girl. Allergol Int 55(2):203–205

    Article  PubMed  Google Scholar 

  64. Asero R (1998) A strange case of “tuna allergy”. Allergy 53(8):816–817

    Article  PubMed  CAS  Google Scholar 

  65. Kalinke DU, Wüthrich B (1999) Purpura pigmentosa progressiva in type III cryoglobulinemia and tartrazine intolerance. A follow-up over 20 years. Hautarzt 50(1):47–51

    Article  PubMed  CAS  Google Scholar 

  66. Michaëlsson G, Pettersson L, Juhlin L (1974) Purpura caused by food and drug additives. Arch Dermatol 109(1):49–52

    Article  PubMed  Google Scholar 

  67. Parodi G, Parodi A, Rebora A (1985) Purpuric vasculitis due to tartrazine. Dermatologica 171(1):62–63

    Article  PubMed  CAS  Google Scholar 

  68. Lowry MD, Hudson CF, Callen JP (1994) Leukocytoclastic vasculitis caused by drug additives. J Am Acad Dermatol 30(5 Pt 2):854–855

    Article  PubMed  CAS  Google Scholar 

  69. Koppel BS, Harden CL, Daras M (1991) Tegretol excipient-induced allergy. Arch Neurol 48(8):789

    Article  PubMed  CAS  Google Scholar 

  70. de Barrio M, Fuentes V, Tornero P, Sánchez I, Zubeldia J, Herrero T (2008) Anaphylaxis to oral iron salts. desensitization protocol for tolerance induction. J Investig Allergol Clin Immunol 18(4):305–308

    PubMed  Google Scholar 

  71. Narama I, Ozaki K, Matsushima S, Matsuura T (1999) Eosinophilic gastroenterocolitis in iron lactate-overloaded rats. Toxicol Pathol 27(3):318–324

    Article  PubMed  CAS  Google Scholar 

  72. Sweatman MC, Tasker R, Warner JO, Ferguson MM, Mitchell DN (1986) Oro-facial granulomatosis. Response to elemental diet and provocation by food additives. Clin Allergy 16(4):331–338

    Article  PubMed  CAS  Google Scholar 

  73. Masuda K, Katoh N, Mizutani H, Kishimoto S (2009) Anaphylaxis to vitamin B2 added to an energy drink. Clin Exp Dermatol 34(7):263–264

    Article  Google Scholar 

  74. Chadwick BL, Hunter ML, Evans MT, Hunter B (1990) Allergic reaction to the food dye patent blue. Br Dent J 168(10):386–387

    Article  PubMed  CAS  Google Scholar 

  75. Foti C, Bonamonte D, Conserva A, Casulli C, Angelini G (2006) Allergic contact dermatitis to glyceryl-hydrogenated rosinate in a topical plaster. Contact Dermatitis 55(2):120–121

    Article  PubMed  Google Scholar 

  76. Bonamonte D, Foti C, Angelini G (2001) Contact allergy to ester gums in cosmetics. Contact Dermatitis 45:110–111

    Article  PubMed  CAS  Google Scholar 

  77. Goossens A, Armingaud P, Avenel-Audran M et al (2002) An epidemic of allergic contact dermatitis due to epilating products. Contact Dermatitis 47:67–70

    Article  PubMed  CAS  Google Scholar 

  78. Jensen CD, Andersen KE (2005) Allergic contact dermatitis from sodium stearoyl lactylate, an emulsifier commonly used in food products. Contact Dermatitis 53(2):116

    Article  PubMed  Google Scholar 

  79. Palm M, Moneret-Vautrin DA, Kanny G, Denery-Papini S, Frémont S (1999) Food allergy to egg and soy lecithins. Allergy 54(10):1116–1117

    Article  PubMed  CAS  Google Scholar 

  80. Renaud C, Cardiet C, Dupont C (1996) Allergy to soy lecithin in a child. J Pediatr Gastroenterol Nutr 22(3):328–329

    Article  PubMed  CAS  Google Scholar 

  81. Lavaud F, Perdu D, Prévost A, Vallerand H, Cossart C, Passemard F (1994) Baker's asthma related to soybean lecithin exposure. Allergy 49(3):159–162

    Article  PubMed  CAS  Google Scholar 

  82. Béliveau S, Gaudreault P, Goulet L, Primeau MN, Marcoux D (2008) Type I hypersensitivity in an asthmatic child allergic to peanuts: was soy lecithin to blame? J Cutan Med Surg 12(1):27–30

    PubMed  Google Scholar 

  83. Awazuhara H, Kawai H, Baba M, Matsui T, Komiyama A (1998) Antigenicity of the proteins in soy lecithin and soy oil in soybean allergy. Clin Exp Allergy 28(12):1559–1564

    Article  PubMed  CAS  Google Scholar 

  84. Gu X, Beardslee T, Zeece M, Sarath G, Markwell J (2001) Identification of IgE-binding proteins in soy lecithin. Int Arch Allergy Immunol 126(3):218–225

    Article  PubMed  CAS  Google Scholar 

  85. Lowther A, McCormick T, Nedorost S (2008) Systemic contact dermatitis from propylene glycol. Dermatitis 19(2):105–108

    PubMed  Google Scholar 

  86. Warshaw EM, Botto NC, Maibach HI, Fowler JF Jr, Rietschel RL, Zug KA, Belsito DV, Taylor JS, DeLeo VA, Pratt MD, Sasseville D, Storrs FJ, Marks JG Jr, Mathias CG (2009) Positive patch-test reactions to propylene glycol: a retrospective cross-sectional analysis from the North American Contact Dermatitis Group, 1996 to 2006. Dermatitis 20(1):14–20

    PubMed  Google Scholar 

  87. Lessmann H, Schnuch A, Geier J, Uter W (2005) Skin-sensitizing and irritant properties of propylene glycol. Contact Dermatitis 53(5):247–259

    Article  PubMed  CAS  Google Scholar 

  88. Curry EJ, Warshaw EM (2005) Benzyl alcohol allergy: importance of patch testing with personal products. Dermatitis 16:203–208

    Article  PubMed  Google Scholar 

  89. Jacob SE, Stechschulte S (2008) Eyelid dermatitis associated with balsam of Peru constituents: benzoic acid and benzyl alcohol. Contact Dermatitis 58:111–112

    Article  PubMed  Google Scholar 

  90. Carrascosa JM, Domingo H, Soria X, Ferrándiz C (2006) Allergic contact dermatitis due to benzyl alcohol in a hair dye. Contact Dermatitis 55(2):124–125

    Article  PubMed  Google Scholar 

  91. Shaw DW (1999) Allergic contact dermatitis to benzyl alcohol in a hearing aid impression material. Am J Contact Dermat 10(4):228–232

    Article  PubMed  CAS  Google Scholar 

  92. Shmunes E (1984) Allergic dermatitis to benzyl alcohol in an injectable solution. Arch Dermatol 120:1200–1201

    Article  PubMed  CAS  Google Scholar 

  93. Podda M, Zollner T, Grundmann-Kollmann M, Kaufmann R, Boehncke WH (1999) Allergic contact dermatitis from benzyl alcohol during topical antimycotic treatment. Contact Dermatitis 41:302

    Article  PubMed  CAS  Google Scholar 

  94. Verecken P, Birringer C, Knitelius AC, Herbaut D, Germaux MA (1998) Sensitization to benzyl alcohol: a possible cause of ‘corticosteroid allergy’. Contact Dermatitis 38:106

    Article  PubMed  CAS  Google Scholar 

  95. Edwards EK (1981) Allergic reactions to benzyl alcohol in a sunscreen. Cutis 28:332–333

    PubMed  Google Scholar 

  96. Corazza M, Mantovani L, Maranini C, Virgili A (1996) Allergic contact dermatitis from benzyl alcohol. Contact Dermatitis 34:74–75

    Article  PubMed  CAS  Google Scholar 

  97. Sestini S, Mori M, Francalanci S (2004) Allergic contact dermatitis from benzyl alcohol in multiple medicaments. Contact Dermatitis 50(5):316–317

    Article  PubMed  Google Scholar 

  98. Turvey SE, Cronin B, Arnold AD, Twarog FJ, Dioun AF (2004) Adverse reactions to vitamin B12 injections due to benzyl alcohol sensitivity: successful treatment with intranasal cyanocobalamin. Allergy 59(9):1023–1024

    Article  PubMed  CAS  Google Scholar 

  99. Amado A, Jacob SE (2007) Letter: Benzyl alcohol preserved saline used to dilute injectables poses a risk of contact dermatitis in fragrance-sensitive patients. Dermatol Surg 33(11):1396–1397

    Article  PubMed  CAS  Google Scholar 

  100. Orton DI, Salim A, Shaw S (2001) Allergic contact cheilitis due to shellac. Contact Dermatitis 44:250

    PubMed  CAS  Google Scholar 

  101. Scheman AJ (1998) Contact allergy to quaternium-22 and shellac in mascara. Contact Dermatitis 38:342

    Article  PubMed  CAS  Google Scholar 

  102. Le Coz CJ, Leclere JM, Arnoult E, Raison-Peyron N, Pons-Guiraud A, Vigan M (2002) Allergic contact dermatitis from shellac in mascara. Contact Dermatitis 46:149–152

    Article  PubMed  Google Scholar 

  103. Gallo R, Marro I, Pavesi A (2005) Allergic contact dermatitis from shellac in mascara. Contact Dermatitis 53:238–239

    Article  PubMed  CAS  Google Scholar 

  104. Strauss RM, Orton DI (2003) Allergic contact cheilitis in the United Kingdom: a retrospective study. Am J Contact Dermat 14(2):75–77

    PubMed  Google Scholar 

  105. Chowdhury MM (2002) Allergic contact dermatitis from prime yellow carnauba wax and coathylene in mascara. Contact Dermatitis 46(4):244

    Article  PubMed  CAS  Google Scholar 

  106. Jacob SE, Chimento S, Castanedo-Tardan MP (2008) Allergic contact dermatitis to propolis and carnauba wax from lip balm and chewable vitamins in a child. Contact Dermatitis 58(4):242–243

    Article  PubMed  Google Scholar 

  107. Vanderburg LE, Wilder EA (2000) The structural constituents of carnauba wax. J Am Oil Chem Soc 47:514–518

    Article  Google Scholar 

  108. Talens P, Krochta JM (2005) Plasticizing effects of bees wax and carnauba wax on tensile and water vapor permeability properties of whey protein films. J Food Sci 70:239–243

    Article  Google Scholar 

  109. Lucente P, Cavalli M, Vezzani C, Orlandi C, Vincenzi C (1996) Contact cheilitis due to beeswax. Contact Dermatitis 35(4):258

    Article  PubMed  CAS  Google Scholar 

  110. Camarasa G (1975) Occupational dermatitis from beeswax Contact dermatitis 1:124

    Article  CAS  Google Scholar 

  111. Schwartz L, Peck SM (1935) The irritants in adhesive plaster. Public Health Rep 50:811

    Article  CAS  Google Scholar 

  112. Sánchez-Pérez J, Diez MB, Pérez AA, Jiménez YD, Diez G (2006) Allergic and systemic contact dermatitis to methylparaben. Contact Dermatitis 54(2):117–118

    Article  PubMed  Google Scholar 

  113. Ishiwatari S, Suzuki T, Hitomi T, Yoshino T, Matsukuma S, Tsuji T (2007) Effects of methyl paraben on skin keratinocytes. J Appl Toxicol 27(1):1–9

    Article  PubMed  CAS  Google Scholar 

  114. Igoe RS (2011) Part II: Ingredient categories. In: Dictionary of food ingredients, 5th edn. Springer, Berlin, p 185

  115. Soni MG, Taylor SL, Greenberg NA, Burdock GA (2002) Evaluation of the health aspects of methyl paraben: a review of the published literature. Food Chem Toxicol 40(10):1335–1373

    Article  PubMed  CAS  Google Scholar 

  116. White-Chu EF, Reddy M (2011) Dry skin in the elderly: complexities of a common problem. Clin Dermatol 29(1):37–42

    Article  PubMed  Google Scholar 

  117. Simon RA (1986) Adverse reactions to food additives. N Engl Reg Allergy Proc 7(6):533–542

    Article  PubMed  CAS  Google Scholar 

  118. Mowad CM (2000) Allergic contact dermatitis caused by parabens: 2 case reports and a review. Am J Contact Dermat 11(1):53–56

    Article  PubMed  CAS  Google Scholar 

  119. Anonymous (2008) Final amended report on the safety assessment of methylparaben, ethylparaben, propylparaben, isopropylparaben, butylparaben, isobutylparaben, and benzylparaben as used in cosmetic products. Int J Toxicol 27(Suppl 4):1–82

  120. Oiso N, Fukai K, Ishii M (2004) Allergic contact dermatitis caused by parabens in a compress. Contact Dermatitis 50(5):317

    Article  PubMed  CAS  Google Scholar 

  121. Soni MG, Carabin IG, Burdock GA (2005) Safety assessment of esters of p-hydroxybenzoic acid (parabens). Food Chem Toxicol 43(7):985–1015

    Article  PubMed  CAS  Google Scholar 

  122. Nagel JE, Fuscaldo JT, Fireman P (1977) Paraben allergy. JAMA 237(15):1594–1595

    Article  PubMed  CAS  Google Scholar 

  123. Vally H, Misso NL, Madan V (2009) Clinical effects of sulphite additives. Clin Exp Allergy 39(11):1643–1651

    Article  PubMed  CAS  Google Scholar 

  124. Lester MR (1995) Sulfite sensitivity: significance in human health. J Am Coll Nutr 14(3):229–232

    PubMed  CAS  Google Scholar 

  125. Nater JP (1968) Allergic contact dermatitis caused by potassium metabisulfite. Dermatologica 136:477–478

    Article  PubMed  CAS  Google Scholar 

  126. Epstein E (1970) Sodium bisulfite. Contact Dermatitis Newsletter 7:155

    Google Scholar 

  127. Apetato M, Marques MS (1986) Contact dermatitis caused by sodium metabisulphite. Contact Dermatitis 14:194

    Article  PubMed  CAS  Google Scholar 

  128. Lee A, Nixon R (2001) Contact dermatitis from sodium metabisulfite in a baker. Contact Dermatitis 44:127–128

    Article  PubMed  CAS  Google Scholar 

  129. Petersen CS, Menne T (1992) Consecutive patch testing with sodium sulfite in eczema patients. Contact Dermatitis 27:344–345

    Article  PubMed  CAS  Google Scholar 

  130. Vena GA, Foti C, Angelini G (1994) Sulfite contact allergy. Contact Dermatitis 31:172–175

    Article  PubMed  CAS  Google Scholar 

  131. Madan V, Walker SL, Beck MH (2007) Sodium metabisulfite allergy is common but is it relevant. Contact Dermatitis 57:173–176

    Article  PubMed  Google Scholar 

  132. Malik MM, Hegarty MA, Bourke JF (2007) Sodium metabisulfite—a marker for cosmetic allergy? Contact Dermatitis 56:241–242

    Article  PubMed  Google Scholar 

  133. Schorr WF (1983) Multiple injuries from permanents. In: Presented at the Cosmetic Symposium. American Academy of Dermatology, Chicago

  134. Sanchez-Perez J, Abajo P, Cordoba S, Garcia-Diez A (2000) Allergic contact dermatitis from sodium metabisulfite in an antihemorrhoidal cream. Contact Dermatitis 42:176–177

    PubMed  CAS  Google Scholar 

  135. Nagayama H, Hatamochi A, Shinkai H (1997) A case of contact dermatitis due to sodium bisulfite in an ophthalmic solution. J Dermatol 24:675–677

    PubMed  CAS  Google Scholar 

  136. Przybilla B, Ring J (1987) Sulfite hypersensitivity. Hautarzt 38(8):445–448

    PubMed  CAS  Google Scholar 

  137. Dooms-Goossens A, de Alam AG, Degreef H, Kochuyt A (1989) Local anesthetic intolerance due to metabisulfite. Contact Dermatitis 20(2):124–126

    Article  PubMed  CAS  Google Scholar 

  138. Smolinske SC (1992) Review of parenteral sulfite reactions. J Toxicol Clin Toxicol 30:597–606

    Article  PubMed  CAS  Google Scholar 

  139. Prenner BM, Stevens JJ (1976) Anaphylaxis after ingestion of sodium bisulfite. Ann Allergy 37:180–182

    PubMed  CAS  Google Scholar 

  140. Wuthrich B, Huwyler T (1989) Asthma due to disulfites. Schweiz Med Wochenschr 119:1177–1184

    PubMed  CAS  Google Scholar 

  141. Tsevat J, Gross GN, Dowling GP (1987) Fatal asthma after ingestion of sulfite-containing wine. Ann Intern Med 107:263

    Article  PubMed  CAS  Google Scholar 

  142. Twarog FJ, Leung DY (1982) Anaphylaxis to a component of isoetharine (sodium bisulfite). JAMA 248:2030–2031

    Article  PubMed  CAS  Google Scholar 

  143. Baker GJ, Collett P, Allen DH (1981) Bronchospasm induced by metabisulphite-containing foods and drugs. Med J Aust 2:614–617

    PubMed  CAS  Google Scholar 

  144. Koepke JW, Selner JC, Dunhill AL (1983) Presence of sulfur dioxide in commonly used bronchodilator solutions. J Allergy Clin Immunol 72:504–508

    Article  PubMed  CAS  Google Scholar 

  145. Sher TH, Schwartz HJ (1985) Bisulfite sensitivity manifesting as an allergic reaction to aerosol therapy. Ann Allergy 54:224–226

    PubMed  CAS  Google Scholar 

  146. Habenicht HA, Preuss L, Lovell RG (1983) Sensitivity to ingested metabisulfites: cause of bronchospasm and urticaria. Immunol Allergy Practice 5:243

    Google Scholar 

  147. Huang AS, Fraser WM (1984) Are sulfite additives really safe? N Engl J Med 311:542

    PubMed  CAS  Google Scholar 

  148. Schwartz HJ (1983) Sensitivity to ingested metabisulfite: variations in clinical presentation. J Allergy Clin Immunol 71:487–489

    Article  PubMed  CAS  Google Scholar 

  149. Valero AL, Bescos M, Amat P, Malet A (1993) Bronchial asthma caused by occupational sulfite exposure. Allergol Immunopathol 21:221–224

    CAS  Google Scholar 

  150. Jacobs MC, Rycroft RJ (1995) Contact dermatitis and asthma from sodium metabisulfite in a photographic technician. Contact Dermatitis 33:65–66

    Article  PubMed  CAS  Google Scholar 

  151. Camarasa JG, Barnadas M (1982) Occupational dermatosis by vitamin K3 sodium bisulphite. Contact Dermatitis 8:268

    Article  PubMed  CAS  Google Scholar 

  152. Malo JL, Cartier A, Desjardins A (1995) Occupational asthma caused by dry metabisulphite. Thorax 50:585–589

    Article  PubMed  CAS  Google Scholar 

  153. Agard C, Nicolet-Akhavan F, Bouillard J, Sandron D (1998) Occupational asthma to metabisulfites. Three cases. Rev Mal Respir 15:537–540

    PubMed  CAS  Google Scholar 

  154. Gunnison AF, Jacobsen DW (1987) Sulfite hypersensitivity. A critical review. CRC Crit Rev Toxicol 17(3):185–214

    Article  PubMed  CAS  Google Scholar 

  155. Steinman HA, Le Roux M, Potter PC (1993) Sulphur dioxide sensitivity in South African asthmatic children. S Afr Med J 83(6):387–390

    PubMed  CAS  Google Scholar 

  156. Arai Y, Muto H, Sano Y, Ito K (1998) Food and food additives hypersensitivity in adult asthmatics. III. Adverse reaction to sulfites in adult asthmatics. Arerugi 47(11):1163–1167

    PubMed  CAS  Google Scholar 

  157. Asero R (2006) Sodium benzoate-induced pruritus. Allergy 61(10):1240–1241

    Article  PubMed  CAS  Google Scholar 

  158. Hong SP, Park HS, Lee MK, Hong CS (1989) Oral provocation tests with aspirin and food additives in asthmatic patients. Yonsei Med J 30(4):339–345

    PubMed  CAS  Google Scholar 

  159. Hannuksela M, Haahtela T (2009) Food additive hypersensitivity—near myth. Duodecim 125(5):527–532

    PubMed  Google Scholar 

  160. Frémont S, Kanny G, Nicolas JP, Moneret-Vautrin DA (1997) Prevalence of lysozyme sensitization in an egg-allergic population. Allergy 52(2):224–228

    Article  PubMed  Google Scholar 

  161. Iaconelli A, Fiorentini L, Bruschi S, Rossi F, Mingrone G, Piva G (2008) Absence of allergic reactions to egg white lysozyme additive in Grana Padano cheese. J Am Coll Nutr 27(2):326–331

    Article  PubMed  CAS  Google Scholar 

  162. Rangan C, Barceloux DG (2009 May) Food additives and sensitivities. Dis Mon 55(5):292–311

    Article  PubMed  Google Scholar 

  163. Bradstock MK, Serdula MK, Marks JS, Barnard RJ, Crane NT, Remington PL, Trowbridge FL (1986) Evaluation of reactions to food additives: the aspartame experience. Am J Clin Nutr 43(3):464–469

    PubMed  CAS  Google Scholar 

  164. Castanedo-Tardan MP, González ME, Connelly EA, Giordano K, Jacob SE (2009) Systematized contact dermatitis and montelukast in an atopic boy. Pediatr Dermatol 26(6):739–743

    Article  PubMed  Google Scholar 

  165. Hill AM, Belsito DV (2003) Systemic contact dermatitis of the eyelids caused by formaldehyde derived from aspartame? Contact Dermatitis 49(5):258–259

    Article  PubMed  Google Scholar 

  166. Hanakawa Y, Hanakawa Y, Tohyama M, Yamasaki K, Hashimoto K (2005) Xylitol as a causative agent of oral erosive eczema. Br J Dermatol 152(4):821–822

    Article  PubMed  Google Scholar 

  167. Hino H, Kasai S, Hattori N, Kenjo K (2000) A case of allergic urticaria caused by erythritol. J Dermatol 27(3):163–165

    PubMed  CAS  Google Scholar 

  168. Ogawa A, Samoto M, Takahashi K (2000) Soybean allergens and hypoallergenic soybean products. J Nutr Sci Vitaminol (Tokyo) 46(6):271–279

    Article  PubMed  CAS  Google Scholar 

  169. European Commission Scientific Committee on Food (2011) Opinion of the scientific committee on food on soybean hemicellulose. SCF/CS/ADD/EMU/185 Final, 10 April 2003, s 7-8. http://ec.europa.eu/food/fs/sc/scf/out187_en.pdf. Last accessed 12 Sep 2011

  170. Taylor SL, Hefle SL (2001) Ingredient and labeling issues associated with allergenic foods. Allergy 56(Suppl 67):64–69

    Article  PubMed  Google Scholar 

  171. JECFA (2011) Propylene glycol alginate. WHO Food Additives Series 32. http://www.inchem.org/documents/jecfa/jecmono/v32je12.htm. Last accessed 12 Sep 2011

  172. Gelfand HH (1949) Vegetable gums by ingestion in etiology of allergic disorders. J Allergy 20:311–321

    Article  Google Scholar 

  173. Figley KD (1940) Karaya gum hypersensitivity. JAMA 104:747

    Google Scholar 

  174. Bullen, Stearns S, Perennial (1934) Fever from Indian gum (karaya gum). J Allergy 5:484

    Article  Google Scholar 

  175. Feinberg SM (1935) Karaya gum asthma. JAMA 105:505

    Google Scholar 

  176. Bowen R (1939) Karaya gum as a cause of urticaria. Arch Dermat & Syph 39:506

    Article  Google Scholar 

  177. JECFA (2011) Karaya gum. WHO Food Additives Series 24, http://www.inchem.org/documents/jecfa/jecmono/v024je06.htm. Last accessed 12 Sep 2011

  178. Wagner W (1980) Karaya gum hypersensitivity in an enterostomal therapist. JAMA 243(5):432

    Article  PubMed  CAS  Google Scholar 

  179. Colwell JC (1984) Karaya sensitivity. J Enterostomal Ther 11(4):159

    PubMed  CAS  Google Scholar 

  180. Camarasa JM, Alomar A (1980) Contact dermatitis from a karaya seal ring. Contact Dermatitis 6(2):139–140

    Article  PubMed  CAS  Google Scholar 

  181. Ronnen M, Suster S, Kahana M, Schewach-Millet M (1986) Contact dermatitis due to karaya gum and induced by the application of electrodes. Int J Dermatol 25(3):189–190

    Article  PubMed  CAS  Google Scholar 

  182. Axelgaard J, Brown JC (1983) Lateral electrical surface stimulation for the treatment of progressive idiopathic scoliosis. Spine 8:242–260

    Article  PubMed  CAS  Google Scholar 

  183. Gelfand HH (1943) The allergenicity of vegetable gums, a case of asthma due to tragacanth. J Allergy 14:203

    Article  CAS  Google Scholar 

  184. Studdeford WE (1937) Severe and fatal reactions following the intravenous use of gum acacia glucose infusions. Surg Gynec Obst 64:772

    Google Scholar 

  185. Spielman AD, Baldwin HS (1933) Atopy to acacia (gum arabic). JAMA 101:444

    Article  Google Scholar 

  186. Feinberg SM, Schoenkerman BB (1940) Karaya and related gums as causes of atopy. Wisconsin MJ 39:734

    CAS  Google Scholar 

  187. Bohner CB, Sheldon JM, Trenis JW (1941) Sensitivity to gum acacia with report of ten cases of asthma in printers. J Allergy 12:290

    Article  Google Scholar 

  188. King JH (1941) Asthma and allergic rhinitis due to gum arabic in non offset spray. J Med 22:119

    Google Scholar 

  189. Ali BH, Ziada A, Blunden G (2009) Biological effects of gum arabic: a review of some recent research. Food Chem Toxicol 47(1):1–8

    Article  PubMed  CAS  Google Scholar 

  190. Fötisch K, Fäh J, Wüthrich B, Altmann F, Haustein D, Vieths S (1998) IgE antibodies specific for carbohydrates in a patient allergic to G.A. (Acacia senegal). Allergy 53:1043–1051

    Article  PubMed  Google Scholar 

  191. Sander I, Raulf-Heimsoth M, Wiemer K, Kespohl S, Brüning T, Merget R (2006) Sensitization due to gum arabic (Acacia senegal): the cause of occupational allergic asthma or crossreaction to carbohydrates? Int Arch Allergy Immunol 141(1):51–56

    Article  PubMed  CAS  Google Scholar 

  192. Lagier F, Cartier A, Somer J, Dolovich J, Malo JL (1990) Occupational asthma caused by guar gum. J Allergy Clin Immunol 85(4):785–790

    Article  PubMed  CAS  Google Scholar 

  193. Kanerva L, Tupasela O, Jolanki R, Vaheri E, Estlander T, Keskinen H (1988) Occupational allergic rhinitis from guar gum. Clin Allergy 18(3):245–252

    Article  PubMed  CAS  Google Scholar 

  194. Papanikolaou I, Stenger R, Bessot JC, de Blay F, Pauli G (2007) Anaphylactic shock to guar gum (food additive E412) contained in a meal substitute. Allergy 62(7):822

    Article  PubMed  CAS  Google Scholar 

  195. Roesch A, Haegele T, Vogt T, Babilas P, Landthaler M, Szeimies RM (2005) Severe contact urticaria to guar gum included as gelling agent in a local anaesthetic. Contact Dermatitis 52(6):307–308

    Article  PubMed  Google Scholar 

  196. Lemière C, Cartier A, Malo JL, Lehrer SB (2000) Persistent specific bronchial reactivity to occupational agents in workers with normal nonspecific bronchial reactivity. Am J Respir Crit Care Med 162(3 Pt 1):976–980

    Article  PubMed  Google Scholar 

  197. Malo JL, Cartier A, Dolovich J (1990) Prevalence of occupational asthma and immunologic sensitization to guar gum among employees at a carpet manufacturing plant. J Allergy Clin Immunol 86:562–569

    Article  PubMed  CAS  Google Scholar 

  198. Savino F, Muratore MC, Silvestro L, Oggero R, Mostert M (1999) Allergy to carob gum in an infant. J Pediatr Gastroenterol Nutr 29:475–476

    Article  PubMed  CAS  Google Scholar 

  199. Alarcón E, del Pozo MD, Bartolomé B, Navarro B, Escudero R, Gonzalez I, Blasco A, Lobera T (2011) Urticaria and angioedema due to ingestion of carob gum: a case report. J Investig Allergol Clin Immunol 21(1):77–78

    PubMed  Google Scholar 

  200. Komericki P, Kränke B (2009) Immediate hypersensitivity to carob pods. Contact Dermatitis 61(4):239–240

    Article  PubMed  Google Scholar 

  201. Scoditti A, Peluso P, Pezzuto R, Giordano T, Melica A (1996) Asthma to carob bean flour. Ann Allergy Asthma Immunol 77(1):81

    Article  PubMed  CAS  Google Scholar 

  202. Van der Brempt X, Ledent C, Mairesse M (1992) Rhinitis and asthma caused by occupational exposure to carob bean flour. J Allergy Clin Immunol 90(6 Pt 1):1008–1010

    Article  PubMed  Google Scholar 

  203. Bush RK (1990) Occupational asthma from vegetable gums. J Allergy Clin Immunol 86:443–444

    Article  PubMed  CAS  Google Scholar 

  204. JECFA (2011) Tragacanth gum. WHO Food Additives Series 20, http://www.inchem.org/documents/jecfa/jecmono/v20je16.htm. Last accessed 12 Sep 2011

  205. Strobel S, Ferguson A, Anderson DM (1986) Immunogenicity, immunological cross reactivity and non-specific irritant properties of the exudate gums, arabic, karaya and tragacanth. Food Addit Contam 3(1):47–56

    Article  PubMed  CAS  Google Scholar 

  206. Cohen AJ, Forse MS, Tarlo SM (1993) Occupational asthma caused by pectin inhalation during the manufacture of jam. Chest 103(1):309–311

    Article  PubMed  CAS  Google Scholar 

  207. Kraut A, Peng Z, Becker AB, Warren CP (1992) Christmas candy maker's asthma. IgG4-mediated pectin allergy. Chest 102(5):1605–1607

    Article  PubMed  CAS  Google Scholar 

  208. Ferdman RM, Ong PY, Church JA (2006) Pectin anaphylaxis and possible association with cashew allergy. Ann Allergy Asthma Immunol 97(6):759–760

    Article  PubMed  Google Scholar 

  209. Nakazawa T (1983) Studies on agriculture and asthma (concerning primarily Konnyaku asthma). Jpn J Traumatol Occup Med 32:10–17

    Google Scholar 

  210. Shichijo K (1951) Research on konjac asthma (first report). Hokesekito Igaku 1:29–39

    Google Scholar 

  211. Bernstein JA, Crandall MS, Floyd R (2007) Respiratory sensitization of a food manufacturing worker to konjac glucomannan. J Asthma 44(8):675–680

    Article  PubMed  Google Scholar 

  212. Tajima S, Kon H, Oshikawa K, Bando M, Ohno S, Sugiyama Y (2003) Hypersensitivity pneumonitis induced by Konjak flour and powdered Hijikia fusiforme. Intern Med 42(9):846–849

    Article  PubMed  Google Scholar 

  213. Allen DH, Baker GJ (1981) Chinese restaurant asthma. [Letter]. N Engl J Med 278:796

    Google Scholar 

  214. Allen DH, Delohery J, Baker G (1987) Monosodium L-glutamate-induced asthma. J Allergy Clin Immunol 80:530–537

    Article  PubMed  CAS  Google Scholar 

  215. Stevenson DD (2000) Monosodium glutamate and asthma. J Nutr 130:1067–1073

    Google Scholar 

  216. Moneret-Vautrin DA (1987) Monosodium glutamate-induced asthma: study of the potential risk of 30 asthmatics and review of the literature. Allerg Immunol (Paris) 19(1):29–35

    PubMed  CAS  Google Scholar 

  217. Schwartzstein R, Kelleher M, Weinberger S, Weiss J, Drazen J (1987) Airway effects of monosodium glutamate in subjects with chronic stable asthma. J Asthma 24:167–172

    Article  PubMed  CAS  Google Scholar 

  218. Germano P, Cohen SG, Hahn B, Metcalfe DD (1991) An evaluation of clinical reactions to monosodium glutamate (MSG) in asthmatics, using a blinded placebo-controlled challenge. J Allergy Clin Immunol 87:177

    Article  Google Scholar 

  219. Woods RK, Weiner JM, Thien F, Abramson M, Walters EH (1998) The effects of monosodium glutamate in adults with asthma who perceive themselves to be monosodium glutamate-intolerant. J Allergy Clin Immunol 101(6 Pt 1):762–771

    Article  PubMed  CAS  Google Scholar 

  220. Yang WH, Drouin MA, Herbert M, Mao Y, Karsh J (1997) The monosodium glutamate symptom complex: assessment in a double-blind, placebo-controlled, randomized study. J Allergy Clin Immunol 99(6 Pt 1):757–762

    Article  PubMed  CAS  Google Scholar 

  221. Woessner KM, Simon RA, Stevenson DD (1999) Monosodium glutamate sensitivity in asthma. J Allergy Clin Immunol 104(2 Pt 1):305–310

    Article  PubMed  CAS  Google Scholar 

  222. Williams AN, Woessner KM (2009) Monosodium glutamate ‘allergy’: menace or myth? Clin Exp Allergy 39(5):640–646

    Article  PubMed  CAS  Google Scholar 

  223. Geha RS, Beiser A, Ren C, Patterson R, Greenberger PA, Grammer LC, Ditto AM, Harris KE, Shaughnessy MA, Yarnold PR, Corren J, Saxon A (2000) Review of alleged reaction to monosodium glutamate and outcome of a multicenter double-blind placebo-controlled study. J Nutr 130(4S Suppl):1058–1062

    Google Scholar 

  224. Supramaniam G, Warner JO (1986) Artificial food additive intolerance in patients with angio-edema and urticaria. Lancet 2:907–909

    Article  PubMed  CAS  Google Scholar 

  225. Botey J, Cozzo M, Marin A, Eseverri JL (1988) Monosodium glutamate and skin pathology in pediatric allergology. Allergol Immunopathol (Madrid) 16:425–428

    CAS  Google Scholar 

  226. Simon RA (2000) Additive-induced urticaria: experience with monosodium glutamate (MSG). J Nutr 130(4S Suppl):1063S–1066S

    PubMed  CAS  Google Scholar 

  227. Asero R (2002) Multiple intolerance to food additives [letter]. J Allergy Clin Immunol 110:531–532

    Article  PubMed  Google Scholar 

  228. Squire EN (1987) Angio-oedema and monosodium glutamate [letter]. Lancet 1:988

    Article  PubMed  Google Scholar 

  229. Asero R (2002) Food additives intolerance: a possible cause of perennial rhinitis [letter]. J Allergy Clin Immunol 110:937

    Article  PubMed  Google Scholar 

  230. Asero R, Bottazzi G (2007) Chronic rhinitis with nasal polyposis associated with sodium glutamate intolerance. Int Arch Allergy Immunol 144:159–161

    Article  PubMed  Google Scholar 

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  1. Medical Biochemistry Department, Medical Faculty, Suleyman Demirel University, Cunur, Isparta, Turkey

    Fatih Gultekin & Duygu Kumbul Doguc

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Gultekin, F., Doguc, D.K. Allergic and Immunologic Reactions to Food Additives. Clinic Rev Allerg Immunol 45, 6–29 (2013). https://doi.org/10.1007/s12016-012-8300-8

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