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Experimental Basis and New Insights for Cell Therapy in Chronic Obstructive Pulmonary Disease

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Abstract

Chronic Obstructive Pulmonary Disease (COPD) can be briefly described as air flow limitation and chronic dyspnea associated to an inflammatory response of the respiratory tract to noxious particles and gases. Its main feature is the obstruction of airflow and consequent chronic dyspnea. Despite recent advances, and the development of new therapeutic, medical and clinical approaches, a curative therapy is yet to be achieved. Therapies involving the use of tissue-specific or donor derived cells present a promising alternative in the treatment of degenerative diseases and injuries. Recent studies demonstrate that mesenchymal stem cells have the capacity to modulate immune responses in acute lung injury and pulmonary fibrosis in animal models, as well as in human patients. Due to these aspects, different groups raised the possibility that the stem cells from different sources, such as those found in bone marrow or adipose tissue, could act preventing the emphysematous lesion progression. In this paper, it is proposed a review of the current state of the art and future perspectives on the use of cell therapy in obstructive lung diseases.

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Acknowledgments

The authors thank Fundunesp – Fundação para o desenvolvimento da UNESP – and the Municipal Government of Assis for the support. The authors Carolina Arruda de Faria, Rodrigo de las Heras Kozma and Talita Stessuk thank were financially supported by Capes – Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.

Conflict of interest

The authors declare no potential conflicts of interest.

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Authors and Affiliations

  1. Program of Post-Graduation in Genetics, University of São Paulo, Ribeirão Preto, São Paulo, Brazil

    Carolina Arruda de Faria

  2. Post-Graduation Program in Biotechnology, USP - Butantan Institute - IPT, São Paulo, São Paulo, Brazil

    Rodrigo de las Heras Kozma & Talita Stessuk

  3. Department of Biological Sciences, University of the State of São Paulo - UNESP, Assis, São Paulo, Brazil

    João Tadeu Ribeiro-Paes

Authors
  1. Carolina Arruda de Faria
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  2. Rodrigo de las Heras Kozma
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  3. Talita Stessuk
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  4. João Tadeu Ribeiro-Paes
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Correspondence to Carolina Arruda de Faria or João Tadeu Ribeiro-Paes.

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de Faria, C.A., de las Heras Kozma, R., Stessuk, T. et al. Experimental Basis and New Insights for Cell Therapy in Chronic Obstructive Pulmonary Disease. Stem Cell Rev and Rep 8, 1236–1244 (2012). https://doi.org/10.1007/s12015-012-9410-7

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