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Immunosuppressive Properties of Mesenchymal Stem Cells

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Abstract

Mesenchymal stem cells (MSC) can be isolated from different adult tissues including bone marrow, adipose tissue, cord blood and placenta. MSCs modulate the immune function of the major immune cell populations involved in alloantigen recognition and elimination, including antigen presenting cells, T cells, B cells and natural killer cells. Many clinical trials are currently underway that employ MSCs to treat human immunological diseases. However, the molecular mechanism that mediates the immunosuppressive effect of MSCs is still unclear and the safety of using MSC in patient needs further confirmation. Here, we review the cytokines that activate MSCs and the soluble factors produced by MSCs, which allow them to exert their immunosuppressive effects. We review the mechanism responsible, at least in part, for the immune suppressive effects of MSCs and highlight areas of research required for a better understanding of MSC immune modulation.

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Acknowledgements

We wish to acknowledge the financial support of KAIMRC Grant No. RC08/114, KACST Grant No. ARP-29-186, NHMRC Grant No. 509178, the RWH Foundation, Cecilia Kilkeary Foundation, Eirene Lucas Foundation, Harold & Cora Brennen Benevolent Trust (Equity Trustees), Jack Brockhoff Foundation, J & R McGauran Charitable Trust, Diana Brown Trust (Perpetual Trustees), Helen Macpherson Smith Trust, Thomas R & Rosalinda B Ditchfield Medical Research Endowment Fund and the Wenkart Foundation. There are no conflicts of interest with respect to the authors of this work.

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Authors and Affiliations

  1. King Saud Bin Abdulaziz University for Health Sciences/King Abdullah International Medical Research Center, King Abdulaziz Medical City, National Guard Health Affairs, P.O. Box 22490, Riyadh, 11426, Mail Code 1515, Saudi Arabia

    Mohamed Abumaree & Mohammed Al Jumah

  2. Department of Obstetrics and Gynaecology, Royal Women’s Hospital, University of Melbourne, Parkville, Victoria, Australia, 3052

    Rishika A. Pace & Bill Kalionis

  3. Department of Perinatal Medicine Pregnancy Research Centre, Royal Women’s Hospital, University of Melbourne, Parkville, Victoria, Australia, 3052

    Rishika A. Pace & Bill Kalionis

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  1. Mohamed Abumaree
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  2. Mohammed Al Jumah
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  4. Bill Kalionis
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Correspondence to Bill Kalionis.

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Abumaree, M., Al Jumah, M., Pace, R.A. et al. Immunosuppressive Properties of Mesenchymal Stem Cells. Stem Cell Rev and Rep 8, 375–392 (2012). https://doi.org/10.1007/s12015-011-9312-0

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