Abstract
The quality of functional outcome has become increasingly important in view of improvement in prognosis with colorectal cancer patients. Sexual dysfunction remains a common problem after colorectal cancer treatment, despite the good oncologic outcomes achieved by expert surgeons. Although radiotherapy and chemotherapy contribute, surgical nerve damage is the main cause of sexual dysfunction. The autonomic nerves are in close contact with the visceral pelvic fascia that surrounds the mesorectum. The concept of total mesorectal excision (TME) in rectal cancer treatment has led to a substantial improvement of autonomic nerve preservation. In addition, use of laparoscopy has allowed favorable results with regards to sexual function. The present paper describes the anatomy and pathophysiology of autonomic pelvic nerves, prevalence of sexual dysfunction, and the surgical technique of nerve preservation in order to maintain sexual function.
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Centers for Disease Control abd Prevention. Cancer survivors- United States. MMWR. 2007;60:269–72.
Heald RJ, Karanjia ND. Results of radical surgery for rectal cancer. World J Surg. 1992;16:848–57.
Murty M, Enker WE, Martz J. Current status of total mesorectal excision and autonomic nerve preservation in rectal cancer. Semin Surg Oncol. 2000;19:321–8.
Denlinger CS, Barsevick AM. The challenges of colorectal cancer survivorship. J Natl Compr Cancer Netw. 2009;7:883–93. quiz 94.
Hendren SK, O'Connor BI, Liu M, et al. Prevalence of male and female sexual dysfunction is high following surgery for rectal cancer. Ann Surg. 2005;242:212–23.
Ho VP, Lee Y, Stein SL, Temple LK. Sexual function after treatment for rectal cancer: a review. Dis Colon Rectum. 2011;54(1):113–25.
Miles W. A method of performing abdominoperineal excision for excision for carcinoma of the rectum and of the terminal portion of the pelvic colon. Lancet. 1908;2:1812–3.
Smith LJ, Mulhall JP, Deveci S, Monaghan N, Reid MC. Sex after seventy: a pilot study of sexual function in older persons. J Sex Med. 2007;4:1247–53.
Balslev I, Harling H. Sexual dysfunction following operation for carcinoma of the rectum. Dis Colon Rectum. 1983;26:785–8.
Danzi M, Ferulano GP, Abate S, Califano G. Male sexual function after abdominoperineal resection for rectal cancer. Dis Colon Rectum. 1983;26:665–8.
Williams JT, Slack WW. A prospective study of sexual function after major colorectal surgery. Br J Surg. 1980;67:772–4.
Fazio VW, Fletcher J, Montague D. Prospective study of the effect of resection of the rectum on male sexual function. World J Surg. 1980;4:149–52.
Santangelo ML, Romano G, Sassaroli C. Sexual function after resection for rectal cancer. Am J Surg. 1987;154:502–4.
Heald RJ. A new approach to rectal cancer. Br J Hosp Med. 1979;22:277–81.
Heald RJ, Ryall RD. Recurrence and survival after total mesorectal excision for rectal cancer. Lancet. 1986;1:1479–82.
Mynster T, Nielsen HJ, Harling H, Bulow S. Blood loss and transfusion after total mesorectal excision and conventional rectal cancer surgery. Colorectal Dis. 2004;6:452–7.
Enker WE. Potency, cure, and local control in the operative treatment of rectal cancer. Arch Surg. 1992;127:1396–401. discussion 402.
Maas CP, Moriya Y, Steup WH, Klein Kranenbarg E, van de Velde CJ. A prospective study on radical and nerve-preserving surgery for rectal cancer in the Netherlands. Eur J Surg Oncol. 2000;26:751–7.
Vironen JH, Kairaluoma M, Aalto AM, Kellokumpu IH. Impact of functional results on quality of life after rectal cancer surgery. Dis Colon Rectum. 2006;49:568–78.
Kapiteijn E, Marijnen CA, Nagtegaal ID, et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med. 2001;345:638–46.
Church JM, Raudkivi PJ, Hill GL. The surgical anatomy of the rectum–a review with particular relevance to the hazards of rectal mobilisation. Int J Colorectal Dis. 1987;2:158–66.
Nano M, Levi AC, Borghi F, et al. Observations on surgical anatomy for rectal cancer surgery. Hepatogastroenterology. 1998;45:717–26.
Ashley FL, Anson BJ. The pelvic autonomic nerves in the male. Surg Gynecol Obstet. 1946;82:598–608.
Lepor H, Gregerman M, Crosby R, Mostofi FK, Walsh PC. Precise localization of the autonomic nerves from the pelvic plexus to the corpora cavernosa: a detailed anatomical study of the adult male pelvis. J Urol. 1985;133:207–12.
Mundy AR. An anatomical explanation for bladder dysfunction following rectal and uterine surgery. Br J Urol. 1982;54:501–4.
Jones OM, Smeulders N, Wiseman O, Miller R. Lateral ligaments of the rectum: an anatomical study. Br J Surg. 1999;86:487–9.
Walsh PC, Donker PJ. Impotence following radical prostatectomy: insight into etiology and prevention. J Urol. 1982;128:492–7.
Zelefsky MJ, Eid JF. Elucidating the etiology of erectile dysfunction after definitive therapy for prostatic cancer. Int J Radiat Oncol Biol Phys. 1998;40:129–33.
•• Lange MM, Marijnen CA, Maas CP, et al. Risk factors for sexual dysfunction after rectal cancer treatment. Eur J Cancer. 2009;45:1578–88. Describes the risk factors that pr-dispose men to sexual difficulty after rectal cancer treatment.
Havenga K, Maas CP, DeRuiter MC, Welvaart K, Trimbos JB. Avoiding long-term disturbance to bladder and sexual function in pelvic surgery, particularly with rectal cancer. Semin Surg Oncol. 2000;18:235–43.
Maurer CA. Urinary and sexual function after total mesorectal excision. Recent Results Cancer Res. 2005;165:196–204.
La Monica G, Audisio RA, Tamburini M, Filiberti A, Ventafridda V. Incidence of sexual dysfunction in male patients treated surgically for rectal malignancy. Dis Colon Rectum. 1985;28:937–40.
Schmidt CE, Bestmann B, Kuchler T, Longo WE, Kremer B. Ten-year historic cohort of quality of life and sexuality in patients with rectal cancer. Dis Colon Rectum. 2005;48:483–92.
•• Akasu T, Sugihara K, Moriya Y. Male urinary and sexual functions after mesorectal excision alone or in combination with extended lateral pelvic lymph node dissection for rectal cancer. Ann Surg Oncol. 2009;16:2779–86. Outlines sexual function after TME.
Burnham WR, Lennard-Jones JE, Brooke BN. Sexual problems among married ileostomists. Survey conducted by The Ileostomy Association of Great Britain and Ireland. Gut. 1977;18:673–7.
Rendall MS, Weden MM, Favreault MM, Waldron H. The protective effect of marriage for survival: a review and update. Demography. 2011;48(2):481–506.
• Milbury K, Cohen L, Jenkins R, et al. The association between psychosocial and medical factors with long-term sexual dysfunction after treatment for colorectal cancer. Support Care Cancer. 2013;21:793–802. Focuses on the psychological impact of colon cancer and sexual function.
Maurer CA, Z'Graggen K, Renzulli P, Schilling MK, Netzer P, Buchler MW. Total mesorectal excision preserves male genital function compared with conventional rectal cancer surgery. Br J Surg. 2001;88:1501–5.
• Morino M, Parini U, Allaix ME, et al. Male sexual and urinary function after laparoscopic total mesorectal excision. Surg Endosc. 2009;23:1233–40. Outlines the beneficial relationship between TME and sexual function.
Quah HM, Jayne DG, Eu KW, Seow-Choen F. Bladder and sexual dysfunction following laparoscopically assisted and conventional open mesorectal resection for cancer. Br J Surg. 2002;89:1551–6.
Jayne DG, Brown JM, Thorpe H, Walker J, Quirke P, Guillou PJ. Bladder and sexual function following resection for rectal cancer in a randomized clinical trial of laparoscopic versus open technique. Br J Surg. 2005;92:1124–32.
McGlone ER, Khan O, Flashman K, Khan J, Parvaiz A. Urogenital function following laparoscopic and open rectal cancer resection: a comparative study. Surg Endosc. 2012;26(9):2559–65.
Kinn AC, Ohman U. Bladder and sexual function after surgery for rectal cancer. Dis Colon Rectum. 1986;29:43–8.
Cunsolo A, Bragaglia RB, Manara G, Poggioli G, Gozzetti G. Urogenital dysfunction after abdominoperineal resection for carcinoma of the rectum. Dis Colon Rectum. 1990;33:918–22.
Hojo K, Vernava 3rd AM, Sugihara K, Katumata K. Preservation of urine voiding and sexual function after rectal cancer surgery. Dis Colon Rectum. 1991;34:532–9.
Koukouras D, Spiliotis J, Scopa CD, et al. Radical consequence in the sexuality of male patients operated for colorectal carcinoma. Eur J Surg Oncol. 1991;17:285–8.
Leveckis J, Boucher NR, Parys BT, Reed MW, Shorthouse AJ, Anderson JB. Bladder and erectile dysfunction before and after rectal surgery for cancer. Br J Urol. 1995;76:752–6.
Havenga K, Enker WE, McDermott K, Cohen AM, Minsky BD, Guillem J. Male and female sexual and urinary function after total mesorectal excision with autonomic nerve preservation for carcinoma of the rectum. J Am Coll Surg. 1996;182:495–502.
Maas CP, Moriya Y, Steup WH, Kiebert GM, Kranenbarg WM, van de Velde CJ. Radical and nerve-preserving surgery for rectal cancer in The Netherlands: a prospective study on morbidity and functional outcome. Br J Surg. 1998;85:92–7.
Saito N, Sarashina H, Nunomura M, Koda K, Takiguchi N, Nakajima N. Clinical evaluation of nerve-sparing surgery combined with preoperative radiotherapy in advanced rectal cancer patients. Am J Surg. 1998;175:277–82.
Nagawa H, Muto T, Sunouchi K, et al. Randomized, controlled trial of lateral node dissection vs. nerve-preserving resection in patients with rectal cancer after preoperative radiotherapy. Dis Colon Rectum. 2001;44:1274–80.
Pocard M, Zinzindohoue F, Haab F, Caplin S, Parc R, Tiret E. A prospective study of sexual and urinary function before and after total mesorectal excision with autonomic nerve preservation for rectal cancer. Surgery. 2002;131:368–72.
Kim NK, Aahn TW, Park JK, et al. Assessment of sexual and voiding function after total mesorectal excision with pelvic autonomic nerve preservation in males with rectal cancer. Dis Colon Rectum. 2002;45:1178–85.
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Dr. Kamal Nagpal reported no potential conflicts of interest relevant to this article.
Dr. Nelson Bennett reported receiving consultancies and travel/accommodations expenses covered or reimbursed from American Medical Systems and Coloplast. Dr. Bennett reported receiving payment for the development of educational presentations, including service on speakers’ bureaus from Pfizer.
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Nagpal, K., Bennett, N. Colorectal Surgery and Its Impact on Male Sexual Function. Curr Urol Rep 14, 279–284 (2013). https://doi.org/10.1007/s11934-013-0341-x
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DOI: https://doi.org/10.1007/s11934-013-0341-x