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Neurocritical Care of a Reperfused Brain

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Abstract

Cerebral hyperperfusion and reperfusion injuries are not infrequently encountered following in reperfusion of ischemic or hypoperfused brain. Mechanism of injury could be related to tissue plasminogen activator toxicity, oxidative stress, and hyperperfusion due to impaired cerebral autoregulation in already maximally dilated cerebral vasculature and compromised cerebral hemodynamic reserve. Reperfusion injury can present as headaches and seizures in mild forms and as subarachnoid hemorrhage, intracranial hemorrhage, cerebral edema, and encephalopathy in its most severe manifestation. Prevention and identifying those at risk of hyperperfusion syndromes are the best strategy. Active treatment includes basic neurocritical care with reduction of blood pressure to a reperfused brain and timely neuroprotection and cerebral edema control measures are the mainstay of its management approach.

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Disclosure

No potential conflicts of interest relevant to this article were reported.

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Authors and Affiliations

  1. Department of Neurology, Radiology and Neurosurgery, Medical College of Wisconsin and Froedtert Hospital West, 9200 West Wisconsin Avenue, Milwaukee, WI, 53226, USA

    Osama O. Zaidat

  2. Department of Neurology, Medical College of Wisconsin and Froedtert Hospital West, Milwaukee, WI, USA

    Aamir Badruddin, Muhammad A. Taqi, Michael G. Abraham & Dhimant Dani

Authors
  1. Aamir Badruddin
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  2. Muhammad A. Taqi
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  3. Michael G. Abraham
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  4. Dhimant Dani
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  5. Osama O. Zaidat
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Corresponding author

Correspondence to Osama O. Zaidat.

Additional information

Aamir Badruddin—Daniel M. Soref Clinical Neuroscience Fellow at Froedtert Hospital (March 2010–June 2011)

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Badruddin, A., Taqi, M.A., Abraham, M.G. et al. Neurocritical Care of a Reperfused Brain. Curr Neurol Neurosci Rep 11, 104–110 (2011). https://doi.org/10.1007/s11910-010-0156-9

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  • DOI: https://doi.org/10.1007/s11910-010-0156-9

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