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Multidrug-Resistant Bacteria in Organ Transplantation: An Emerging Threat with Limited Therapeutic Options

  • Transplant and Oncology (M Ison and N Theodoropoulos, Section Editors)
  • Published:
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Abstract

Multidrug-resistant organisms (MDROs) are an emerging threat in solid organ transplantation (SOT). The changing epidemiology of these MDROs is reviewed along with the growing evidence regarding risk factors and outcomes associated with both colonization and infection in SOT. The management of these infections is complicated by the lack of antimicrobial agents available to treat these infections, and only a handful of new agents, especially for the treatment of MDR GNR infections, are being evaluated in clinical trials. Due to the increased prevalence of MDROs and limited treatment options, as well as organ shortages, transplant candidacy and use of organs from donors with evidence of MDRO colonization and/or infection remain controversial. Increasing collaboration between transplant programs, individual practitioners, infection control programs, and researchers in antimicrobial development will be needed to face this challenge.

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Gopi Patel, Meenakshi M. Rana, and Shirish Huprikar declare that they have no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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  1. Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1090, New York, NY, 10029, USA

    Gopi Patel, Meenakshi M. Rana & Shirish Huprikar

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  1. Gopi Patel
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  2. Meenakshi M. Rana
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  3. Shirish Huprikar
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Correspondence to Shirish Huprikar.

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Patel, G., Rana, M.M. & Huprikar, S. Multidrug-Resistant Bacteria in Organ Transplantation: An Emerging Threat with Limited Therapeutic Options. Curr Infect Dis Rep 15, 504–513 (2013). https://doi.org/10.1007/s11908-013-0371-z

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