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Pediatric Sepsis: Preparing for the Future Against a Global Scourge

  • Sepsis (J Russell, Section Editor)
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Abstract

Sepsis is a leading cause of morbidity and mortality among children worldwide. As consensus statements emerge regarding early recognition and goal-directed management of sepsis, scrutiny should be given to the unique characteristics of sepsis in children. Pediatric patients are not small adults! Sepsis epidemiology, pathophysiology, and management strategy can vary significantly from those for adults. Herein, we describe the epidemiology of pediatric sepsis, in both resource-rich and resource-poor worlds, and discuss how the pathophysiology of pediatric sepsis differs from that for adults. We discuss the timeline of management of pediatric sepsis, studying how discoveries over the past 50 years have changed the way sepsis is treated. Finally, we discuss the future of pediatric sepsis. We focus on approaches that carry the most substantive impact on the global burden of disease.

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Acknowledgements

Supported by AHRQ R18 HS020455

Disclosure

Dr. D. Wheeler’s institution has received grant support from AHRQ. No other potential conflicts of interest relevant to this article were reported.

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Authors and Affiliations

  1. Division of Critical Care Medicine, Cincinnati Children’s Hospital and Medical Center, 3333 Burnet Avenue, Division of Critical Care, ML 2005, Cincinnati, OH, 45229, USA

    Carley Riley, Rajit K. Basu & Derek S. Wheeler

  2. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA

    Rajit K. Basu & Derek S. Wheeler

  3. The James M. Anderson Center for Health Systems Excellence, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

    Derek S. Wheeler

  4. Division of Critical Care, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada

    Niranjan Kissoon

  5. British Columbia Children’s Hospital, Vancouver, BC, Canada

    Niranjan Kissoon

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  1. Carley Riley
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Riley, C., Basu, R.K., Kissoon, N. et al. Pediatric Sepsis: Preparing for the Future Against a Global Scourge. Curr Infect Dis Rep 14, 503–511 (2012). https://doi.org/10.1007/s11908-012-0281-5

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