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Antihypertensive treatment and new-onset diabetes mellitus

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Abstract

The various antihypertensive regimens have varying effects on glucose metabolism and the development of diabetes mellitus. Recent large hypertension trials have shown great differences in the development of new-onset diabetes among antihypertensive drug therapies. The incidence of diabetes is unchanged or increased by thiazide diuretics and β-adrenergic blockers, and unchanged or decreased by angiotensin-converting enzyme inhibitors, calcium channel blockers, and angiotensin-receptor blockers. The differences in new-onset diabetes mellitus have not influenced the outcome of cardiovascular mortality and morbidity in all of the large clinical trials, but drug-induced diabetes among hypertensive patients is known to carry the same cardiovascular risk as that seen in patients with previously known diabetes; however, it might take years for the increased risk to become apparent.

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Authors and Affiliations

  1. Clinica Medica, Ospedale S Gerardo, University of Milan-Bicocca, Via Donizetti 106, 200 52, Monza, Italy

    Tonje Amb Aksnes MD, Henrik M. Reims MD, Sverre E. Kjeldsen MD, PhD & Giuseppe Mancia MD, PhD

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  1. Tonje Amb Aksnes MD
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  2. Henrik M. Reims MD
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  3. Sverre E. Kjeldsen MD, PhD
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  4. Giuseppe Mancia MD, PhD
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Aksnes, T.A., Reims, H.M., Kjeldsen, S.E. et al. Antihypertensive treatment and new-onset diabetes mellitus. Current Science Inc 7, 298–303 (2005). https://doi.org/10.1007/s11906-005-0029-9

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