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Treatment Considerations for HIV-Infected Individuals with Severe Mental Illness

  • Behavioral Aspects of HIV Management (RJ DiClemente and JL Brown, Section Editors)
  • Published:
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Abstract

There has been a general recognition of a syndemic that includes HIV/AIDS and serve mental illnesses including schizophrenia, major depression, bipolar disorder, post-traumatic stress disorder, and others. The pathophysiology and direction of effects between severe mental illness and HIV infection is less clear however, and relatively little work has been done on prevention and treatment for people with these complex, co-occurring conditions. Here we present the most recent work that has been published on HIV and mental illness. Further, we describe the need for better treatments for “triply diagnosed persons”; those with HIV, mental illness, and substance abuse and dependence. Finally, we describe the potential drug-drug interactions between psychotropic medications and anti-retrovirals, and the need for better treatment guidelines in this area. We describe one example of an individually tailored intervention for persons with serious mental illness and HIV (PATH+) that shows that integrated community-based treatments using advanced practice nurses (APNs) as health navigators can be successful in improving health-related quality of life and reducing the burden of disease in these persons.

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Acknowledgments

This project was in part supported by P30-AI45008 (Hoxie, PI) Penn Center for AIDS Research (CFAR), and by P30 MH097488-01 (Evans, PI) Penn Mental Health AIDS Research Center.

Compliance with Ethics Guidelines

ᅟ

Conflict of Interest

James Walkup received honoraria, payment for development of education presentations, and travel/acommodations expenses covered or reimbursed by the Columbia University HIV Mental Health Training Project.

Michael B. Blank, Seth Himelhoch, and Marlene M. Eiensberg declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Center for Mental Health Policy and Services Research, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, 3535 Market St., room 3020, Philadelphia, PA, 19104-3309, USA

    Michael B. Blank

  2. Division of Psychiatric Services Research, Department of Psychiatry, University of Maryland School of Medicine, 701 W. Pratt Street, 388, Baltimore, MD, USA

    Seth Himelhoch

  3. Institute for Health, Health Care Policy and Aging Research, Rutgers, The State University of New Jersey, 112 Paterson, New Brunswick, NJ, 08504, USA

    James Walkup

  4. Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, 3535 Market St., Suite 4000, Philadelphia, PA, 19104, USA

    Marlene M. Eisenberg

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  1. Michael B. Blank
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  2. Seth Himelhoch
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  3. James Walkup
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  4. Marlene M. Eisenberg
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Correspondence to Michael B. Blank.

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Blank, M.B., Himelhoch, S., Walkup, J. et al. Treatment Considerations for HIV-Infected Individuals with Severe Mental Illness. Curr HIV/AIDS Rep 10, 371–379 (2013). https://doi.org/10.1007/s11904-013-0179-3

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