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IL28B Genotype on HCV Infection in Asia

  • Global Perspectives: Taiwan and Asia (ML Yu and RN Chien, Section Editors)
  • Published:
Current Hepatitis Reports Aims and scope Submit manuscript

Abstract

Hepatitis C virus (HCV) infection is the leading cause of cirrhosis, hepatic decompensation, hepatocellular carcinoma (HCC). Successful HCV eradication can reduce the liver-related mortality and morbidity. Previous studies show that Asian HCV-1 patients tend to have higher sustained virologic response (SVR) rates than Caucasian, Hispanic or African-American HCV-1 patients. Recent genome-wide association studies (GWAS) reveal interleukin-28B (IL28B) genotypes at locus rs12979860 or rs8099917 are strong predictors for SVR in HCV-1 patients treated with peginterferon-α (PEG-IFN-α) plus ribavirin (RBV), and the higher frequencies of favorable IL28B genotype in Asian patients than those in other ethnicity may explain the superior response in Asian HCV-1 patients. However, the predictive role of IL28B genotype is limited for HCV-2 patients and for HCV patients with response-guided therapy. IL28B genotype still predicts SVR in patients with triple therapy by telaprevir (TVR) or boceprevir (BOC). For newer direct-acting antivirals (DAAs), its predictive role remains to be confirmed.

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Acknowledgments

The study was supported by grants from the National Taiwan University Hospital; the National Science Council, and Department of Health, Executive Yuan, Taiwan.

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Conflict of Interest

Chen-Hua Liu declares that he has no conflict of interest.

Jia-Horng Kao declares that he is the consultant for Abbott, Bristol-Myers Squibb, Gilead Sciences, GlaxoSmithKline, Merck Sharp & Dohme, Novartis, and Roche and he is on speaker’s bureau for Abbott, Roche, Bayer, Bristol-Myers Squibb, GlaxoSmithKline, and Novartis.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Department of Internal Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan

    Chen-Hua Liu & Jia-Horng Kao

  2. Hepatitis Research Center, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan

    Chen-Hua Liu & Jia-Horng Kao

  3. Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, 1 Chang-Te St., Taipei, 10002, Taiwan

    Chen-Hua Liu & Jia-Horng Kao

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  1. Chen-Hua Liu
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  2. Jia-Horng Kao
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Correspondence to Jia-Horng Kao.

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Liu, CH., Kao, JH. IL28B Genotype on HCV Infection in Asia. Curr Hepatitis Rep 12, 149–156 (2013). https://doi.org/10.1007/s11901-013-0176-4

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