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First-line treatment of Hodgkin’s lymphoma

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Abstract

Substantial clinical progress over the last decades has made Hodgkin’s lymphoma into one of the most curable human cancers in adults. About 80% of patients in all stages and of all histologic subtypes experience long-term disease-free survival. Modern treatment strategies aim to improve chemotherapy and radiotherapy, while minimizing therapy-related toxicities. Ongoing trials investigate a reduction of chemotherapy doses or cycles and the application of lower radiation doses and smaller radiation field sizes. For patients with a specific high-risk profile, novel approaches with more intense drug combinations are currently being investigated in clinical trials. This review discusses recent approaches to the first-line treatment of early-favorable, early-unfavorable, and advanced-stage Hodgkin’s lymphoma.

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Authors and Affiliations

  1. First Department of Internal Medicine, University Hospital Cologne, Herderstr. 52, 50931, Cologne, Germany

    Beate Klimm MD

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  1. Beate Klimm MD
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  2. Andreas Engert MD
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  3. Volker Diehl MD
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Correspondence to Beate Klimm MD.

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Klimm, B., Engert, A. & Diehl, V. First-line treatment of Hodgkin’s lymphoma. Curr Hematol Malig Rep 1, 51–59 (2006). https://doi.org/10.1007/s11899-006-0018-3

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