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Neurologic Complications of Bariatric Surgery: Involvement of Central, Peripheral, and Enteric Nervous Systems

  • Nutrition and Obesity (S McClave, Section Editor)
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Abstract

Approximately one in three Americans is obese. Current society guidelines recommend bariatric surgery after conservative measures at weight loss have failed. The frequency of bariatric surgeries has increased significantly over the past decade. While considered both safe and effective, bariatric surgery presents a distinct set of risks. This review focuses on the neurological complications of bariatric surgery. Injuries have been reported at all levels of the nervous system, including the central, peripheral, and enteric nervous system. Injury can be classified according to time of presentation and location. The two main mechanisms of nerve injury are from mechanical injury or as a consequence of malnutrition. Encephalopathy, peripheral neuropathies, myelopathies, and radiculoneuropathies have all been reported. Mechanical injuries likely occur from mechanical compression. Malnutrition injuries result from multi-micronutrient deficiencies. The most likely candidates are vitamin B12, folate, zinc, thiamin, copper, vitamin A, and vitamin E deficiencies.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. • Flegal KM, Carroll MD, Kit BK, et al. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999–2010. JAMA. 2012;307(5):491–7. Most current review of obesity trends in the United States.

    Article  PubMed  Google Scholar 

  2. In The Surgeon General's Call To Action To Prevent and Decrease Overweight and Obesity. 2001: Rockville (MD).

  3. Finkelstein EA, Trogdon JG, Cohen JW, et al. Annual medical spending attributable to obesity: payer-and service-specific estimates. Health Aff (Millwood). 2009;28(5):w822–31.

    Article  Google Scholar 

  4. Riley, K. FDA expands use of banding system for weight loss. 2011; Available from: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm245617.htm.

  5. • Park CW, Torquati A. Physiology of weight loss surgery. Surg Clin North Am. 2011;91(6):1149–61. vii, Excellent review of the physiologic effects of bariatric surgery.

    Article  PubMed  Google Scholar 

  6. Pontiroli AE, Morabito A. Long-term prevention of mortality in morbid obesity through bariatric surgery: a systematic review and meta-analysis of trials performed with gastric banding and gastric bypass. Ann Surg. 2011;253(3):484–7.

    Article  PubMed  Google Scholar 

  7. Nguyen NT, Masoomi H, Magno CP, et al. Trends in use of bariatric surgery, 2003–2008. J Am Coll Surg. 2011;213(2):261–6.

    Article  PubMed  Google Scholar 

  8. Livingston EH. The incidence of bariatric surgery has plateaued in the U.S. Am J Surg. 2010;200(3):378–85.

    Article  PubMed  Google Scholar 

  9. Longitudinal Assessment of Bariatric Surgery, Flum DR, Belle SH, et al. Perioperative safety in the longitudinal assessment of bariatric surgery. N Engl J Med. 2009;361(5):445–54.

    Article  PubMed  Google Scholar 

  10. Buchwald H, Estok R, Fahrbach K, et al. Trends in mortality in bariatric surgery: a systematic review and meta-analysis. Surgery. 2007;142(4):621–32. discussion 632–5.

    Article  PubMed  Google Scholar 

  11. Padwal R, Klarenbach S, Wiebe N, et al. Bariatric surgery: a systematic review and network meta-analysis of randomized trials. Obes Rev. 2011;12(8):602–21.

    Article  PubMed  CAS  Google Scholar 

  12. DeMaria EJ, Pate V, Warthen M, et al. Baseline data from American Society for Metabolic and Bariatric Surgery-designated Bariatric Surgery Centers of Excellence using the Bariatric Outcomes Longitudinal Database. Surg Obes Relat Dis. 2010;6(4):347–55.

    Article  PubMed  Google Scholar 

  13. Macgregor AM, Thoburn EK. Meralgia paresthetica following bariatric surgery. Obes Surg. 1999;9(4):364–8.

    Article  PubMed  CAS  Google Scholar 

  14. Shafi MA, Pasricha PJ. Post-surgical and obstructive gastroparesis. Curr Gastroenterol Rep. 2007;9(4):280–5.

    Article  PubMed  Google Scholar 

  15. McGlinch BP, Que FG, Nelson JL, et al. Perioperative care of patients undergoing bariatric surgery. Mayo Clin Proc. 2006;81(10 Suppl):S25–33.

    PubMed  Google Scholar 

  16. Shah RN, Izanec JL, Friedel DM, et al. Achalasia presenting after operative and nonoperative trauma. Dig Dis Sci. 2004;49(11–12):1818–21.

    Article  PubMed  Google Scholar 

  17. Cubattoli L, Barneschi C, Mastrocinque E, et al. Cardiac arrest after intragastric balloon insertion in a super-obese patient. Obes Surg. 2009;19(2):253–6.

    Article  PubMed  Google Scholar 

  18. Benevides ML, Nochi RJ. Junior: [Rhabdomyolysis secondary to gluteal compartment syndrome after bariatric surgery: case report.]. Rev Bras Anestesiol. 2006;56(4):408–12.

    Article  PubMed  Google Scholar 

  19. Rodriguez Uranga JJ, Ucles Sanchez AJ, Perez Diaz JM. Neuropathy of common sciatic nerve secondary to compartment syndrome as a complication after bariatric surgery. Neurologia. 2005;20(2):94–7.

    PubMed  CAS  Google Scholar 

  20. Oluigbo N, Fallouh B, Suresh V. Cardiac arrest following adjustment of a gastric band. Obes Surg. 2008;18(6):750–2.

    Article  PubMed  Google Scholar 

  21. Abarbanel JM, Berginer VM, Osimani A, et al. Neurologic complications after gastric restriction surgery for morbid obesity. Neurology. 1987;37(2):196–200.

    Article  PubMed  CAS  Google Scholar 

  22. Thaisetthawatkul P, Collazo-Clavell ML, Sarr MG, et al. A controlled study of peripheral neuropathy after bariatric surgery. Neurology. 2004;63(8):1462–70.

    Article  PubMed  CAS  Google Scholar 

  23. Singh S, Nautiyal A. Neurologic complications of bariatric surgery. Mayo Clin Proc. 2005;80(1):136–7. author reply 137.

    PubMed  Google Scholar 

  24. Mason ME, Jalagani H, Vinik AI. Metabolic complications of bariatric surgery: diagnosis and management issues. Gastroenterol Clin North Am. 2005;34(1):25–33.

    Article  PubMed  Google Scholar 

  25. Thaisetthawatkul P. Neuromuscular complications of bariatric surgery. Phys Med Rehabil Clin N Am. 2008;19(1):111–24. vii.

    Article  PubMed  Google Scholar 

  26. •• Kumar N. Neurologic presentations of nutritional deficiencies. Neurol Clin. 2010;28(1):107–70. Excellent review of the neurologic manifestations of micronutrient deficiencies. First part of the review contains tables that can be used as a pocket reference. Does an excellent job going reviewing outlining diagnostic workup for nutrient deficiencies.

    Article  PubMed  Google Scholar 

  27. •• Kazemi A, Frazier T, Cave M. Micronutrient-related neurologic complications following bariatric surgery. Curr Gastroenterol Rep. 2010;12(4):288–95. Excellent review of the current literature exploring specific micronutrient deficiencies associated with neurologic dysfunction after bariatric surgery.

    Article  PubMed  Google Scholar 

  28. Aasheim ET. Wernicke encephalopathy after bariatric surgery: a systematic review. Ann Surg. 2008;248(5):714–20.

    PubMed  Google Scholar 

  29. Koffman BM, Greenfield II LJ, et al. Neurologic complications after surgery for obesity. Muscle Nerve. 2006;33(2):166–76.

    Article  PubMed  Google Scholar 

  30. Chang CG, Adams-Huet B, Provost DA. Acute post-gastric reduction surgery (APGARS) neuropathy. Obes Surg. 2004;14(2):182–9.

    Article  PubMed  Google Scholar 

  31. Juhasz-Pocsine K, Rudnicki SA, Archer RL, et al. Neurologic complications of gastric bypass surgery for morbid obesity. Neurology. 2007;68(21):1843–50.

    Article  PubMed  Google Scholar 

  32. Colquitt JL, Picot J, Loveman E, et al. Surgery for obesity. Cochrane Database Syst Rev. 2009;2009(2):CD003641.

    Google Scholar 

  33. •• Mechanick JI, Kushner RF, Sugerman HJ, et al. American Association of Clinical Endocrinologists, The Obesity Society, and American Society for Metabolic & Bariatric Surgery medical guidelines for clinical practice for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient. Obesity (Silver Spring). 2009;17 Suppl 1:S1–70. v, Comprehensive professional tri-society guidelines for the care of bariatric surgery patients. Recommended reference for all providers caring for patients after bariatric surgery.

    Google Scholar 

  34. Bal B, Koch TR, Finelli FC, et al. Managing medical and surgical disorders after divided Roux-en-Y gastric bypass surgery. Nat Rev Gastroenterol Hepatol. 2010;7(6):320–34.

    PubMed  Google Scholar 

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Disclosures: Dr. Frantz has no relevant disclosures.

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Frantz, D.J. Neurologic Complications of Bariatric Surgery: Involvement of Central, Peripheral, and Enteric Nervous Systems. Curr Gastroenterol Rep 14, 367–372 (2012). https://doi.org/10.1007/s11894-012-0271-7

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