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Insights on pathogenesis of type 2 diabetes from MODY genetics

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Abstract

Maturity-onset diabetes of the young (MODY) is a type of non-insulin-dependent diabetes mellitus caused by rare autosomal-dominant mutations. MODY genes play key biochemical roles in the pancreatic β cell; therefore, common variants of MODY genes are excellent candidate genes for type 2 diabetes. We review recent studies that suggest that common MODY gene variation contributes modestly to the heritability of type 2 diabetes.

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  1. Institute of Biomedical & Clinical Sciences, Peninsula College of Medicine & Dentistry, Peninsula Medical School, St. Lukes Campus, Magdalen Road, Exeter, EX1 2LU, UK

    Michael N. Weedon PhD

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  2. Timothy M. Frayling PhD
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Correspondence to Michael N. Weedon PhD.

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Weedon, M.N., Frayling, T.M. Insights on pathogenesis of type 2 diabetes from MODY genetics. Curr Diab Rep 7, 131–138 (2007). https://doi.org/10.1007/s11892-007-0022-6

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