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Protein and Coronary Heart Disease: The Role of Different Protein Sources

  • Nutrition (William S. Harris, Section Editor)
  • Published:
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Abstract

Meat protein is associated with an increase in risk of heart disease. Recent data have shown that meat protein appeared to be associated with weight gain over 6.5 years, with 1 kg of weight increase per 125 g of meat per day. In the Nurses’ Health Study, diets low in red meat, containing nuts, low-fat dairy, poultry, or fish, were associated with a 13% to 30% lower risk of CHD compared with diets high in meat. Low-carbohydrate diets high in animal protein were associated with a 23% higher total mortality rate whereas low-carbohydrate diets high in vegetable protein were associated with a 20% lower total mortality rate. Recent soy interventions have been assessed by the American Heart Association and found to be associated with only small reductions in LDL cholesterol. Although dairy intake has been associated with a lower weight and lower insulin resistance and metabolic syndrome, the only long-term (6 months) dairy intervention performed so far has shown no effects on these parameters.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. • Halkjær J, Olsen A, Overvad K, et al Intake of total, animal and plant protein and subsequent changes in weight or waist circumference in European men and women: the Diogenes project. Int J Obes (Lond). 2010 Dec 7. [Epub ahead of print]. This article shows that animal protein (except dairy and fish) was related to weight gain (but no waist circumference) over 6.5 years.

  2. • Vergnaud AC, Norat T, Romaguera D, et al. Meat consumption and prospective weight change in participants of the EPIC-PANACEA study. Am J Clin Nutr. 2010;92:398–407. This article shows a 1-kg gain in weight over 5 years for every 125 g/d of meat.

    Article  PubMed  CAS  Google Scholar 

  3. •• Bernstein AM, Sun Q, Hu FB, et al. Major dietary protein sources and risk of coronary heart disease in women. Circulation. 2010;122:876–83. It was calculated that if participants replaced red meat with nuts, low-fat dairy, poultry, or fish it would lead to a 13% to 30% lower risk of CHD, with fish being the best replacement option.

    Article  PubMed  CAS  Google Scholar 

  4. • Preis SR, Stampfer MJ, Spiegelman D, Willett WC, Rimm EB. Dietary protein and risk of ischemic heart disease in middle-aged men. Am J Clin Nutr. 2010;92:1265–72. No association was seen between dietary protein and risk of total IHD in this group of men aged 40 to 75 years.

    Article  PubMed  CAS  Google Scholar 

  5. Craig WJ, Mangels AR. American Dietetic Association. Position of the American Dietetic Association: vegetarian diets. J Am Diet Assoc. 2009;109(7):1266–82.

    Article  PubMed  CAS  Google Scholar 

  6. •• Fung TT, van Dam RM, Hankinson SE, et al. Low-carbohydrate diets and all-cause and cause-specific mortality: two cohort studies. Ann Intern Med. 2010;153:289–98. A higher animal low-carbohydrate score was associated with a 23% higher all-cause mortality comparing extreme deciles (P < 0.05). A higher vegetable low-carbohydrate score was associated with a 20% lower all-cause mortality (P for trend ≤ 0.001).

    PubMed  Google Scholar 

  7. Umesawa M, Sato S, Imano H, et al. Relations between protein intake and blood pressure in Japanese men and women: the Circulatory Risk in Communities Study (CIRCS). Am J Clin Nutr. 2009;90:377–84.

    Article  PubMed  CAS  Google Scholar 

  8. Sauvaget C, Nagano J, Allen N, Grant EJ, Beral V. Intake of animal products and stroke mortality in the Hiroshima/Nagasaki Life Span Study. Int J Epidemiol. 2003;32:536–43.

    Article  PubMed  Google Scholar 

  9. Preis SR, Stampfer MJ, Spiegelman D, et al. Lack of association between dietary protein intake and risk of stroke among middle-aged men. Am J Clin Nutr. 2010;91:39–45.

    Article  PubMed  CAS  Google Scholar 

  10. Wang ET, de Koning L, Kanaya AM. Higher protein intake is associated with diabetes risk in South Asian Indians: the Metabolic Syndrome and Atherosclerosis in South Asians Living in America (MASALA) study. J Am Coll Nutr. 2010;29:130–5.

    PubMed  CAS  Google Scholar 

  11. • Liese AD, Weis KE, Schulz M, Tooze JA. Food intake patterns associated with incident type 2 diabetes: the Insulin Resistance Atherosclerosis Study. Diabetes Care. 2009;32:263–8. A wide variety of animal protein sources were associated with the development of type 2 diabetes.

    Article  PubMed  CAS  Google Scholar 

  12. McNaughton SA, Mishra GD, Brunner EJ. Dietary patterns, insulin resistance, and incidence of type 2 diabetes in the Whitehall II Study. Diabetes Care. 2008;31(7):1343–8.

    Article  PubMed  Google Scholar 

  13. Halton TL, Willett WC, Liu S, et al. Low-carbohydrate-diet score and the risk of coronary heart disease in women. N Engl J Med. 2006;355:1999–2002.

    Article  Google Scholar 

  14. •• Aune D, Ursin G, Veierød MB. Meat consumption and the risk of type 2 diabetes: a systematic review and meta-analysis of cohort studies. Diabetologia. 2009;52(11):2277–87. Red meat is clearly associated with the development of type 2 diabetes.

    Article  PubMed  CAS  Google Scholar 

  15. Schulze MB, Schulz M, Heidemann C, et al. Carbohydrate intake and incidence of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Br J Nutr. 2008;99:1107–16.

    Article  PubMed  CAS  Google Scholar 

  16. Villegas R, Gao YT, Yang G, et al. Legume and soy food intake and the incidence of type 2 diabetes in the Shanghai Women’s Health Study. Am J Clin Nutr. 2008;87:162–7.

    PubMed  CAS  Google Scholar 

  17. Zhang X, Shu XO, Gao YT, et al. Soy food consumption is associated with lower risk of coronary heart disease in Chinese women. J Nutr. 2003;133:2874–8.

    PubMed  CAS  Google Scholar 

  18. • van Meijl LE, Vrolix R, Mensink RP. Dairy product consumption and the metabolic syndrome. Nutr Res Rev. 2008;21:148–57. Review. Dairy foods seem to protect against the development of insulin resistance and the metabolic syndrome.

    Article  PubMed  Google Scholar 

  19. German JB, Gibson RA, Krauss RM, et al. A reappraisal of the impact of dairy foods and milk fat on cardiovascular disease risk. Eur J Nutr. 2009;48:191–203.

    Article  PubMed  CAS  Google Scholar 

  20. • Mozaffarian D, Cao H, King IB, et al. Trans-palmitoleic acid, metabolic risk factors, and new-onset diabetes in U.S. adults: a cohort study. Ann Intern Med. 2010;153:790–9. Dairy intake as judged by trans-palmitoleic acid levels is associated with lower rates of type 2 diabetes.

    PubMed  Google Scholar 

  21. Liao FH, Shieh MJ, Yang SC, et al. Effectiveness of a soy-based compared with a traditional low-calorie diet on weight loss and lipid levels in overweight adults. Nutrition. 2007;23:551–6.

    Article  PubMed  CAS  Google Scholar 

  22. Gardner CD, Messina M, Kiazand A, et al. Effect of two types of soy milk and dairy milk on plasma lipids in hypercholesterolemic adults: a randomized trial. J Am Coll Nutr. 2007;26:669–77.

    PubMed  CAS  Google Scholar 

  23. Jenkins DJ, Wong JM, Kendall CW, et al. The effect of a plant-based low-carbohydrate (“Eco-Atkins”) diet on body weight and blood lipid concentrations in hyperlipidemic subjects. Arch Intern Med. 2009;169:1046–54.

    Article  PubMed  CAS  Google Scholar 

  24. • Wycherley TP, Brinkworth GD, Keogh JB, et al. Long-term effects of weight loss with a very low carbohydrate and low fat diet on vascular function in overweight and obese patients. J Intern Med. 2010;267:452–61. A high saturated fat diet increased LDL cholesterol and impaired vascular function despite a 14-kg weight loss.

    Article  PubMed  CAS  Google Scholar 

  25. Brinkworth GD, Noakes M, Buckley JD, et al. Long-term effects of a very-low-carbohydrate weight loss diet compared with an isocaloric low-fat diet after 12 mo. Am J Clin Nutr. 2009;90:23–32.

    Article  PubMed  CAS  Google Scholar 

  26. Aldrich ND, Reicks MM, Shalamar D, et al. Varying protein source and quantity do not significantly improve weight loss, fat loss, or satiety in reduced energy diets among midlife adults. Nutr Res. 2011;31(2):104–12.

    Article  PubMed  CAS  Google Scholar 

  27. Abete I, Parra D, Martinez JA. Legume-, fish-, or high-protein-based hypocaloric diets: effects on weight loss and mitochondrial oxidation in obese men. J Med Food. 2009;12:100–8. doi:10.1089/jmf.2007.0700.

    Article  PubMed  CAS  Google Scholar 

  28. •• Wennersberg MH, Smedman A, Turpeinen AM, et al. Dairy products and metabolic effects in overweight men and women: results from a 6-mo intervention study. Am J Clin Nutr. 2009;90:960–8. This study showed no effects of increasing dairy to 4 to 5 servings per day on weight or metabolic measures.

    Article  PubMed  CAS  Google Scholar 

  29. Xiao CW. Health effects of soy protein and isoflavones in humans. J Nutr. 2008;138:1244S–9S.

    PubMed  CAS  Google Scholar 

  30. Ferdowsian HR, Barnard ND. Effects of plant-based diets on plasma lipids. Am J Cardiol. 2009;104:947–56.

    Article  PubMed  Google Scholar 

  31. Thorp AA, Howe PR, Mori TA, et al. Soy food consumption does not lower LDL cholesterol in either equol or nonequol producers. Am J Clin Nutr. 2008;88:298–304.

    PubMed  CAS  Google Scholar 

  32. Campbell SC, Khalil DA, Payton ME, Arjmandi BH. One-year soy protein supplementation does not improve lipid profile in postmenopausal women. Menopause. 2010;17:587–93.

    PubMed  Google Scholar 

  33. Kris-Etherton PM, Hu FB, Ros E, Sabaté J. The role of tree nuts and peanuts in the prevention of coronary heart disease: multiple potential mechanisms. J Nutr. 2008;138:1746S–51S.

    PubMed  CAS  Google Scholar 

  34. Altorf-van der Kuil W, Engberink MF, Brink EJ, et al. Dietary protein and blood pressure: a systematic review. PLoS One. 2010;5:e12102.

    Article  PubMed  Google Scholar 

  35. Hodgson JM, Burke V, Beilin LJ, Puddey IB. Partial substitution of carbohydrate intake with protein intake from lean red meat lowers blood pressure in hypertensive persons. Am J Clin Nutr. 2006;83:780–7.

    PubMed  CAS  Google Scholar 

  36. Wang YF, Yancy Jr WS, Yu D, et al. The relationship between dietary protein intake and blood pressure: results from the PREMIER study. J Hum Hypertens. 2008;22:745–54.

    Article  PubMed  CAS  Google Scholar 

  37. Lin PH, Miwa S, Li YJ, et al. Champagne C. Factors influencing dietary protein sources in the PREMIER trial population. J Am Diet Assoc. 2010;110:291–5.

    Article  PubMed  CAS  Google Scholar 

  38. Burke LE, Hudson AG, Warziski MT, et al. Effects of a vegetarian diet and treatment preference on biochemical and dietary variables in overweight and obese adults: a randomized clinical trial. Am J Clin Nutr. 2007;86(3):588–96.

    PubMed  CAS  Google Scholar 

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Clifton, P.M. Protein and Coronary Heart Disease: The Role of Different Protein Sources. Curr Atheroscler Rep 13, 493–498 (2011). https://doi.org/10.1007/s11883-011-0208-x

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