Abstract
Introduction
Gastrointestinal symptoms such as heartburn, indigestion (or dyspepsia), bloating, distension, constipation, abdominal pain, abdominal discomfort and diarrhoea are extremely common worldwide. For some, such symptoms can prove to be chronic and disabling.
Methods
The recent literature on irritable bowel syndrome and, in particular, work emanating form this authors research group, was reviewed.
Results
These functional symptoms commonly occur in aggregations, referred to as functional gastrointestinal disorders (FGIDs). Some of the FGIDs and, most notably irritable bowel syndrome (IBS), have achieved a degree of scientific and clinical credibility as coherent entities. Several lines of evidence ranging from gut motility to the microbiota are under investigation in attempts to explain IBS or its symptomatology.
Conclusion
Though biomarkers for IBS and other FGIDs have proven elusive, considerable progress has been made in understanding possible aetiological factors in IBS; progress which may well lead to better therapeutic strategies.
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Acknowledgments
Based on the 52nd Robert Graves lecture. The author wishes to acknowledge the contributions of the many co-investigators, collaborators, post-graduate and undergraduate students, as well as nursing, technical and administrative staff who have contributed to the research described in this paper. These studies have been supported, in part, by a grant from Science Foundation Ireland to the Alimentary Pharmabiotic Centre.
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Quigley, E.M.M. Bugs on the brain; brain in the gut—seeking explanations for common gastrointestinal symptoms. Ir J Med Sci 182, 1–6 (2013). https://doi.org/10.1007/s11845-012-0865-y
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DOI: https://doi.org/10.1007/s11845-012-0865-y