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Recombinant activated factor VII to control life-threatening haemorrhagic radiation cystitis

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Abstract

Introduction

The use of recombinant activated factor VII has been described for many clinical scenarios, but the value of this therapeutic agent for life-threatening haemorrhagic cystitis remains novel.

Method

We describe a case of persistent life-threatening haemorrhagic radiation cystitis, and discuss current knowledge of this therapy including potential complications.

Result

Control of haemorrhage was successfully achieved only after use of this agent.

Conclusion

This therapy deserves mention in any future management algorithm devised for this condition.

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References

  1. Levi M, Peters M, Buller HR (2005) Efficacy and safety of recombinant factor VIIa for treatment of severe bleeding: a systematic review. Crit Care Med 33(4):883–890. doi:10.1097/01.CCM.0000159087.85970.38

    Article  CAS  PubMed  Google Scholar 

  2. Geisler JP, Linnemeier GC, Manahan KJ (2008) Recombinant factor VIIa to treat late radiation-induced haemorrhagic cystitis. J Reprod Med 53(5):360–362

    PubMed  Google Scholar 

  3. Choong SKS, Walkden M, Kirby R (2000) The management of intractable haematuria. BJU Int 86:951–959. doi:10.1046/j.1464-410x.2000.00900.x

    Article  CAS  PubMed  Google Scholar 

  4. Crew JP, Jephcott CR, Reynard JM (2001) Radiation-induced haemorrhagic cystitis. Eur Urol 40:111–123. doi:10.1159/000049760

    Article  CAS  PubMed  Google Scholar 

  5. Bevers RFM, Bakker DJ, Kurth KH (1995) Hyperbaric oxygen treatment for haemorrhagic radiation cystitis. Lancet 346:803–805. doi:10.1016/S0140-6736(95)91620-2

    Article  CAS  PubMed  Google Scholar 

  6. Helmstein K (1972) Treatment of bladder carcinoma by a hydrostatic pressure technique. Br J Urol 44:434–450. doi:10.1111/j.1464-410X.1972.tb10103.x

    Article  CAS  PubMed  Google Scholar 

  7. Brown RB (1969) A method of management of inoperable carcinoma of the bladder. Med J Aust 1:23

    CAS  PubMed  Google Scholar 

  8. Hald T, Mygind T (1974) Control of life-threatening vesical haemorrhage by unilateral hypogastric artery muscle embolization. J Urol 112:60–63

    CAS  PubMed  Google Scholar 

  9. Khan AZ, Parry JM, Crowley WF, McAllen K, Pharm D, Davis AT, Bonnell BW, Hoogeboom JE (2005) Recombinant factor VIIa for the treatment of severe postoperative and traumatic haemorrhage. Am J Surg 189:331–334. doi:10.1016/j.amjsurg.2004.11.021

    Article  CAS  PubMed  Google Scholar 

  10. Friederich PW, Henny CP, Messelink EJ, Geerdink MG, Keller T, Kurth KH, Buller HR, Levi M (2003) Effect of recombinant activated factor VII on perioperative blood loss in patients undergoing retropubic prostatectomy: a double-blind placebo-controlled randomised trial. Lancet 361:201–205. doi:10.1016/S0140-6736(03)12268-4

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Urology, University College Hospital Galway, Galway, Ireland

    S. S. Connolly, F. T. D’Arcy & M. O. Corcoran

Authors
  1. S. S. Connolly
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  2. F. T. D’Arcy
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  3. M. O. Corcoran
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Correspondence to S. S. Connolly.

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Connolly, S.S., D’Arcy, F.T. & Corcoran, M.O. Recombinant activated factor VII to control life-threatening haemorrhagic radiation cystitis. Ir J Med Sci 179, 431–433 (2010). https://doi.org/10.1007/s11845-009-0324-6

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  • DOI: https://doi.org/10.1007/s11845-009-0324-6

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