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Laparoscopic Adjustable Gastric Banding Reduces Subcutaneous Adipose Tissue and Blood Inflammation in Nondiabetic Morbidly Obese Individuals

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Abstract

Background

Significant and sustained excess weight loss (EWL) appears to reduce the risk of obesity-related comorbidities (insulin resistance, hyperlipidemia, and inflammation), but this has been primarily shown in adult diabetic obese patients. We evaluated whether the EWL obtained 3 years after laparoscopic adjustable gastric banding (LAGB) improves the metabolic phenotype in nondiabetic morbidly obese (NDMO) individuals from south Italy.

Methods

Serum and subcutaneous adipose tissue (SAT) samples from 20 obese individuals (median BMI = 41.5 kg/m2) before (T0) and after LAGB (T1) and from 10 controls (median BMI = 22.8 kg/m2) were taken. Serum leptin, adiponectin, C reactive protein (CRP), and main analyte levels were evaluated by routine methods or immunoassay. In SAT, adipocyte size was measured by hematoxylin/eosin staining, cluster of differentiation 68 (CD68) macrophage infiltration marker by immunohistochemistry, and adiponectin, adiponectin receptors 1 and 2, and interleukin 6 (IL6) messenger RNAs by qRT-PCR.

Results

The average EWL was 66.7 %, and CRP, triglycerides, hepatic markers, leptin levels, homeostasis model assessment, and the leptin/adiponectin ratio were lower (p < 0.05) at T1 than at T0. The expression of small adipocytes and adiponectin was increased (p < 0.05), and inflammation markers (CD68 and IL6) decreased (p < 0.05) at T1 vs. T0. At linear regression multivariate analysis, over 90 % (R 2 = 0.905) of EWL (dependent variable) was explained by CD68, adiponectinemia, triglyceridemia, CRP, and total protein levels.

Conclusions

The EWL obtained 3 years after LAGB resulted in an improvement of lipid metabolism and a reduction of inflammation in NDMO patients, thereby decreasing the risk of obesity-associated diseases.

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Acknowledgments

We thank Jean Ann Gilder (Scientific Communication srl, Naples, Italy) for revising and editing the manuscript. Grants from CEINGE Regione Campania (DGRC 1901/2009), IRCCS Fondazione SDN, Ministry of Health, POR Campania FSE 2007-2013-CUP B25B09000050007, PRIN 2008, Project CREME, and Project PON02_00619_3461281 are acknowledged.

Conflict of Interest

The authors declare no conflicts of interest.

Author information

Authors and Affiliations

  1. CEINGE-Biotecnologie Avanzate S.C.a R.L., Via G. Salvatore 486, 80145, Naples, Italy

    Laura Iaffaldano, Carmela Nardelli, Donatella Montanaro, Maddalena Ferrigno, Alfonso Baldi & Lucia Sacchetti

  2. Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, Via S. Pansini 5, 80131, Naples, Italy

    Carmela Nardelli & Lucia Sacchetti

  3. Dipartimento di Medicina e Chirurgia, Università degli Studi di Salerno, Via Giovanni Paolo II 132, 84084, Fisciano, Salerno, Italy

    Vincenzo Pilone

  4. IRCCS Fondazione SDN–Istituto di Ricerca Diagnostica e Nucleare, Via Gianturco 113, 80142, Naples, Italy

    Giuseppe Labruna, Maria Restituta Zeccolella & Pasqualina Buono

  5. Dipartimento Scienze Motorie e del Benessere, Università degli Studi di Napoli Parthenope, Via Amm. F. Acton 38, 80133, Naples, Italy

    Andreina Alfieri & Pasqualina Buono

  6. Dipartimento di Scienze Biomediche Avanzate, Università degli Studi di Napoli Federico II, Via S. Pansini 5, 80131, Naples, Italy

    Nicola Carlomagno & Andrea Renda

  7. Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Seconda Università degli Studi di Napoli, Via Vivaldi 43, 81100, Caserta, Italy

    Alfonso Baldi

  8. Dipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Napoli Federico II, Via S. Pansini 5, 80131, Naples, Italy

    Pietro Forestieri

Authors
  1. Laura Iaffaldano
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  2. Carmela Nardelli
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  3. Vincenzo Pilone
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  4. Giuseppe Labruna
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  5. Andreina Alfieri
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  6. Donatella Montanaro
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  8. Maria Restituta Zeccolella
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  9. Nicola Carlomagno
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  10. Andrea Renda
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  11. Alfonso Baldi
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  12. Pietro Forestieri
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  13. Lucia Sacchetti
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  14. Pasqualina Buono
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Corresponding author

Correspondence to Lucia Sacchetti.

Additional information

Laura Iaffaldano and Carmela Nardelli contributed equally to this paper.

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Iaffaldano, L., Nardelli, C., Pilone, V. et al. Laparoscopic Adjustable Gastric Banding Reduces Subcutaneous Adipose Tissue and Blood Inflammation in Nondiabetic Morbidly Obese Individuals. OBES SURG 24, 2161–2168 (2014). https://doi.org/10.1007/s11695-014-1326-7

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  • DOI: https://doi.org/10.1007/s11695-014-1326-7

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