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Comparison of Gastric Fundus Invagination and Gastric Greater Curvature Plication for Weight Loss in a Rat Model of Diet-Induced Obesity

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Abstract

Background

Gastric fundus invagination (GFI) is a novel weight loss procedure. The gastric fundus is invaginated inside the gastric lumen and anastomosed to the gastric antrum. In gastric plication (GP), the greater curvature is plicated inside the gastric lumen leaving a narrow gastric channel for food passage. This study compares GFI to GP in a diet-induced obesity rat model.

Methods

Twenty Long-Evans male rats were fed a 60 % high fat diet for 6 weeks. At 14 weeks of age, the rats underwent either GFI (N = 10) or GP (N = 10) surgery. Body weight and food intake were measured for 6 weeks. Serum adipokines and ghrelin hormone were assayed. Six weeks after surgery, all rats were euthanized and the stomachs examined. The two-sample t test was used to compare the results between the two groups.

Results

All GFI rats had an intact fundus invagination at 6 weeks following surgery. The greater curvature plication unfurled in three out of ten GP rats. Part of the fundus herniated through the plication suture line in one GP rat. There was no significant difference between the mean percent weight change for the GFI (4.2 ± 4.1 %) and GP (8.8 ± 6.0 %) groups. There was no difference in food intake between both groups. GFI was associated with a significant lower fasting ghrelin levels (101.1 ± 13.1 versus 137.3 ± 27.4; p = 0.044) compared with GP.

Conclusions

GFI offers a more effective and more durable surgical alternative for weight loss than GP.

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References

  1. Mason EE. Development and future of gastroplasties for morbid obesity. Arch Surg. 2003;138:361–6.

    Article  PubMed  Google Scholar 

  2. Tretbar LL, Taylor TL, Sifers EC. Weight reduction. Gastric plication for morbid obesity. J Kans Med Soc. 1976;77(11):488–90.

    CAS  PubMed  Google Scholar 

  3. Brethauer SA, Harris JL, Kroh M, et al. Laparoscopic gastric plication for treatment of severe obesity. Surg Obes Relat Dis. 2011;7:15–22.

    Article  PubMed  Google Scholar 

  4. Spiegelman BM, Flier JS. Obesity and the regulation of energy balance. Cell. 2001;104:531–43.

    Article  CAS  PubMed  Google Scholar 

  5. Sumithran P, Prendergast LA, Delbridge E, et al. Long-term persistence of hormonal adaptations to weight loss. N Engl J Med. 2011;365:1597–604.

    Article  CAS  PubMed  Google Scholar 

  6. Scott WR, Batterham RL. Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy: understanding weight loss and improvements in type 2 diabetes after bariatric surgery. Am J Physiol Regul Integr Comp Physiol. 2011;301:R15–27.

    Article  CAS  PubMed  Google Scholar 

  7. Valderas JP, Irribarra V, Rubio L, et al. Effects of sleeve gastrectomy and medical treatment for obesity on glucagon-like peptide 1 levels and glucose homeostasis in non-diabetic subjects. Obes Surg. 2011;21:902–9.

    Article  PubMed  Google Scholar 

  8. Lindeboom MY, Vu MK, Ringers J, et al. Function of the proximal stomach after partial versus complete laparoscopic fundoplication. Am J Gastroenterol. 2003;98:284–90.

    Article  CAS  PubMed  Google Scholar 

  9. Longo KA, Charoenthongtrakul S, Giuliana DJ, et al. Improved insulin sensitivity and metabolic flexibility in ghrelin receptor knockout mice. Regul Pept. 2008;150(1–3):55–61.

    Article  CAS  PubMed  Google Scholar 

  10. Cummings DE, Weigle DS, Frayo RS, et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Eng J Med. 2002;346(21):1623–30.

    Article  Google Scholar 

  11. Dimitriadis E, Daskalakis M, Kampa M, et al. Alterations in gut hormones after laparoscopic sleeve gastrectomy: a prospective clinical laboratory investigational study. Ann Surg. 2013;257(4):647–54.

    Article  PubMed  Google Scholar 

  12. Shen D, Ye H, Wang Y, et al. Comparison of short-term outcomes between laparoscopic greater curvature plication and laparoscopic sleeve gastrectomy. Surg Endosc. 2013;27:2768–74.

    Article  PubMed  Google Scholar 

  13. Fusco PE, Poggetti RS, Younes RN, et al. Evaluation of gastric greater curvature invagination for weight loss in rats. Obes Surg. 2006;16:172–7.

    Article  PubMed  Google Scholar 

  14. Fusco PE, Poggetti RS, Younes RN, et al. Comparison of anterior gastric wall and greater gastric curvature invaginations for weight loss in rats. Obes Surg. 2007;17:1340–5.

    Article  PubMed  Google Scholar 

  15. Menchaca HJ, Harris TL, Thompson SE, et al. Gastric plication: a pre-clinical study of the durability of serosa-to-serosa apposition. Surg Obes Relat Dis. 2011;7(1):8–14.

    Article  PubMed  Google Scholar 

  16. Guimaraes M, Nora M, Ferreira T, et al. Sleeve gastrectomy and gastric plication in the rat result in weight loss with different endocrine profiles. Obes Surg. 2013;23:710–7.

    Article  PubMed  Google Scholar 

  17. Talebpour M, Amoli BS. Laparoscopic total gastric vertical plication in morbid obesity. J Laparoendosc Adv Surg Tech A. 2007;17(16):793–8.

    Article  PubMed  Google Scholar 

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Conflict of Interest

None of the authors have a conflict of interest to declare.

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Authors and Affiliations

  1. Metabolic and Bariatric Surgery, AnMed Health, 2000 E. Greenville Street, Suite 2600, Anderson, SC, 29621, USA

    Elias Darido

  2. College of Business, Anderson University, 316 Boulevard, Anderson, SC, 29621, USA

    Jeffery R. Moore

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  1. Elias Darido
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  2. Jeffery R. Moore
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Correspondence to Elias Darido.

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Darido, E., Moore, J.R. Comparison of Gastric Fundus Invagination and Gastric Greater Curvature Plication for Weight Loss in a Rat Model of Diet-Induced Obesity. OBES SURG 24, 897–902 (2014). https://doi.org/10.1007/s11695-014-1181-6

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  • DOI: https://doi.org/10.1007/s11695-014-1181-6

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