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DTI tractography and white matter fiber tract characteristics in euthymic bipolar I patients and healthy control subjects

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Abstract

With the introduction of diffusion tensor imaging (DTI), structural differences in white matter (WM) architecture between psychiatric populations and healthy controls can be systematically observed and measured. In particular, DTI-tractography can be used to assess WM characteristics over the entire extent of WM tracts and aggregated fiber bundles. Using 64-direction DTI scanning in 27 participants with bipolar disorder (BD) and 26 age-and-gender-matched healthy control subjects, we compared relative length, density, and fractional anisotrophy (FA) of WM tracts involved in emotion regulation or theorized to be important neural components in BD neuropathology. We interactively isolated 22 known white matter tracts using region-of-interest placement (TrackVis software program) and then computed relative tract length, density, and integrity. BD subjects demonstrated significantly shorter WM tracts in the genu, body and splenium of the corpus callosum compared to healthy controls. Additionally, bipolar subjects exhibited reduced fiber density in the genu and body of the corpus callosum, and in the inferior longitudinal fasciculus bilaterally. In the left uncinate fasciculus, however, BD subjects exhibited significantly greater fiber density than healthy controls. There were no significant differences between groups in WM tract FA for those tracts that began and ended in the brain. The significance of differences in tract length and fiber density in BD is discussed.

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Acknowledgments

This work was supported by grants to LLA from the National Institute of Mental Health (R21MH086104, R21MH085944) and a generous donation from the HF Foundation.

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Authors and Affiliations

  1. Laboratory of Neuro Imaging (LONI), Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, 635 Charles E. Young Dr. S, Los Angeles, CA, 90095, USA

    Carinna M. Torgerson, Andrei Irimia & John Darrell Van Horn

  2. Department of Psychiatry, Department of Bioengineering, University of Illinois Chicago and Community Psychiatry Associates, Sacramento, California, Room 584, 1601 West Taylor Street, Chicago, IL, 60612, USA

    Alex D. Leow

  3. Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, 300 Medical Plaza, Suite 1544, Box 956968, Los Angeles, CA, 90095-7057, USA

    George Bartzokis & Teena D. Moody

  4. ADCS Imaging Core, University of California San Diego, 8950 Villa La Jolla Drive Suite 216, San Diego, CA, 92037, USA

    Robin G. Jennings & Lori L. Altshuler

  5. Department of Radiology, David Geffen School of Medicine, University of California Los Angeles, 660 Charles E. Young Dr. S, Los Angeles, CA, 90095, USA

    Jeffry R. Alger

  6. Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, Los Angeles, CA, USA

    Lori L. Altshuler

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  1. Carinna M. Torgerson
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  2. Andrei Irimia
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  3. Alex D. Leow
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Correspondence to Carinna M. Torgerson.

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Torgerson, C.M., Irimia, A., Leow, A.D. et al. DTI tractography and white matter fiber tract characteristics in euthymic bipolar I patients and healthy control subjects. Brain Imaging and Behavior 7, 129–139 (2013). https://doi.org/10.1007/s11682-012-9202-3

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