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Sleeve Gastrectomy Provides a Better Control of Diabetes by Decreasing Ghrelin in the Diabetic Goto–Kakizaki Rats

  • Original Article
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Journal of Gastrointestinal Surgery Aims and scope

Abstract

Aim

Sleeve gastrectomy (SG) and modified duodenal jejunal bypass (MDJB) were compared as procedures for glucose control. We aim to form the initial conclusions with respect to the possibility of (1) whether gastric fundus exclusion is essential for the control of diabetes and (2) application as a low morbidity procedure.

Materials and Methods

SG and MDJB were performed on 10- to 12-week-old Goto–Kakizaki rats that spontaneously develop type 2 diabetes. Rats were observed for 36 weeks after surgery, and glucose, insulin, glucagons-like peptide-1 (GLP-1), glucose tolerate, insulin sensitivity, cholesterol, triglycerides, and free fatty acid levels were measured.

Results

Apart from distinct weight loss of SG and MDJB after 1 month compared with sham-operated rats (P < 0.001), SG showed strikingly improved blood glucose levels and significantly decreased Ghrelin secretion (P < 0.001). Furthermore, SG resulted in a shorter operative time (P < 0.01) and postoperative recovery time (P < 0.01) than MDJB group.

Conclusions

SG shows better control in terms of glucose tolerance and other measurements. This study provides direct evidence that SG possesses better improvement of diabetes by reduction of Ghrelin.

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Abbreviations

SG:

Sleeve gastrectomy

GK:

Goto–Kakizaki

MDJB:

Modified duodenal jejunal bypass

OGTT:

Oral glucose tolerance test

ITT:

Insulin tolerance test

GLP-1:

Glucagon-like peptide-1

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Authors and Affiliations

  1. Department of General Surgery, Qilu Hospital of Shandong University, 107#, Wenhua Xi Road, Jinan, 250012, Shandong, People’s Republic of China

    Feng Li, Guangyong Zhang, Jianwei Liang, Xiangjiu Ding, Zhiqiang Cheng & Sanyuan Hu

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  1. Feng Li
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  2. Guangyong Zhang
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  3. Jianwei Liang
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Correspondence to Sanyuan Hu.

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Li, F., Zhang, G., Liang, J. et al. Sleeve Gastrectomy Provides a Better Control of Diabetes by Decreasing Ghrelin in the Diabetic Goto–Kakizaki Rats. J Gastrointest Surg 13, 2302–2308 (2009). https://doi.org/10.1007/s11605-009-0997-1

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  • DOI: https://doi.org/10.1007/s11605-009-0997-1

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