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Body weight-tailored contrast material injection protocol for 64-detector row computed tomography coronary angiography

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Abstract

Purpose

The aim of this study was to assess the body weight-tailored contrast material injection protocol for 64-detector computed tomography (CT) to maintain optimal coronary CT attenuation.

Materials and methods

A total of 60 patients who underwent CT coronary angiography were assigned to one of three groups: protocol A, total of 0.7 ml kg−1 with 300 mg I/ml iodine concentration; protocol B, total of 0.6 ml kg−1 with 350 mg I/ml; protocol C, total of 0.7 ml kg−1 with 350 mg I/ml. The injection duration was 10 s in all patients. The proportion of intracoronary attenuation values >325 HU was compared on a pervessel and per-patient basis.

Results

The attenuation value was significantly more likely to exceed 325 HU with protocol C (95% for reader 1 and 90% for reader 2) than with protocol A or B on the per-vessel analysis (P < 0.05). The attenuation value also signifi cantly exceeded 325 HU with protocol C (95% and 90%, respectively) more often than with protocol A or B on the per-patient analysis (P < 0.05).

Conclusion

A total of at least 0.7 ml kg−1 contrast material with 350 mg/ml iodine concentration is required to achieve optimal coronary CT attenuation (>325 HU) with 64-detector CT when using an injection duration of 10 s.

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References

  1. Goldstein JA, Gallagher MJ, O’Neill WW, Ross MA, O’Neil BJ, Raff GL. A randomized controlled trial of multi-slice coronary computed tomography for evaluation of acute chest pain. J Am Coll Cardiol 2007;49:863–871.

    Article  PubMed  Google Scholar 

  2. Herzog C, Zwerner PL, Doll JR, Nielsen CD, Nguyen SA, Savino G, et al. Signifi cant coronary artery stenosis: comparison on per-patient and per-vessel or per-segment basis at 64-section CT angiography. Radiology 2007;244:112–120.

    Article  PubMed  Google Scholar 

  3. Johnson TR, Nikolaou K, Busch S, Leber AW, Becker A, Wintersperger BJ, et al. Diagnostic accuracy of dual-source computed tomography in the diagnosis of coronary artery disease. Invest Radiol 2007;42:684–691.

    Article  PubMed  Google Scholar 

  4. Budoff MJ, Dowe D, Jollis JG, Gitter M, Sutherland J, Halamert E, et al. Diagnostic performance of 64-multidetector row coronary computed tomographic angiography for evaluation of coronary artery stenosis in individuals without known coronary artery disease: results from the prospective multicenter ACCURACY (Assessment by Coronary Computed Tomographic Angiography of Individuals Undergoing Invasive Coronary Angiography) trial. J Am Coll Cardiol 2008;52:1724–1732.

    Article  PubMed  Google Scholar 

  5. Miller JM, Rochitte CE, Dewey M, Arbab-Zadeh A, Niinuma H, Gottlieb I, et al. Diagnostic performance of coronary angiography by 64-row CT. N Engl J Med 2008;359:2324–2336.

    Article  CAS  PubMed  Google Scholar 

  6. Becker CR, Hong C, Knez A, Leber A, Bruening R, Schoepf UJ, et al. Optimal contrast application for cardiac 4-detectorrow computed tomography. Invest Radiol 2003;38:690–694.

    Article  PubMed  Google Scholar 

  7. Rist C, Nikolaou K, Kirchin MA, van Gessel R, Bae KT, von Ziegler F, et al. Contrast bolus optimization for cardiac 16-slice computed tomography: comparison of contrast medium formulations containing 300 and 400 milligrams of iodine per milliliter. Invest Radiol 2006;41:460–467.

    Article  PubMed  Google Scholar 

  8. Cademartiri F, Mollet NR, van der Lugt A, McFadden EP, Stijnen T, de Feyter PJ, et al. Intravenous contrast material administration at helical 16-detector row CT coronary angiography: effect of iodine concentration on vascular attenuation. Radiology 2005;236:661–665.

    Article  PubMed  Google Scholar 

  9. Cademartiri F, de Monye C, Pugliese F, Mollet NR, Runza G, van der Lugt A, et al. High iodine concentration contrast material for noninvasive multislice computed tomography coronary angiography: iopromide 370 versus iomeprol 400. Invest Radiol 2006;41:349–353.

    Article  PubMed  Google Scholar 

  10. Cademartiri F, Mollet NR, Lemos PA, Saia F, Midiri M, de Feyter PJ, et al. Higher intracoronary attenuation improves diagnostic accuracy in MDCT coronary angiography. AJR Am J Roentgenol 2006;187:W430–W433.

    Article  PubMed  Google Scholar 

  11. Cademartiri F, Maffei E, Palumbo AA, Malagò R, La Grutta L, Meiijboom WB, et al. Infl uence of intra-coronary enhancement on diagnostic accuracy with 64-slice CT coronary angiography. Eur Radiol 2008;18:576–583.

    Article  PubMed  Google Scholar 

  12. Yamamuro M, Tadamura E, Kanao S, Wu YW, Tambara K, Komeda M, et al. Coronary angiography by 64-detector row computed tomography using low dose of contrast material with saline chaser: infl uence of total injection volume on vessel attenuation. J Comput Assist Tomogr 2007;31:272–280.

    Article  PubMed  Google Scholar 

  13. Bae KT, Seeck BA, Hildebolt CF, Tao C, Zhu F, Kanematsu M, et al. Contrast enhancement in cardiovascular MDCT: effect of body weight, height, body surface area, body mass index, and obesity. AJR Am J Roentgenol 2008;190:777–784.

    Article  PubMed  Google Scholar 

  14. Nakaura T, Awai K, Yanaga Y, Nakayama Y, Oda S, Hatemura M, et al. Contrast injection protocols for coronary computed tomography angiography using a 64-detector scanner: comparison between patient weight-adjusted and fixed iodinedose protocols. Invest Radiol 2008;43:512–519.

    Article  PubMed  Google Scholar 

  15. Hirai N, Horiguchi J, Fujioka C, Kiguchi M, Yamamoto H, Matsuura N, et al. Prospective versus retrospective ECG-gated 64-detector coronary CT angiography: assessment of image quality, stenosis, and radiation dose. Radiology 2008;248:424–430.

    Article  PubMed  Google Scholar 

  16. Cademartiri F, van der Lugt A, Luccichenti G, Pavone P, Krestin GP. Parameters affecting bolus geometry in CTA: a review. J Comput Assist Tomogr 2002;26:598–607.

    Article  PubMed  Google Scholar 

  17. Bae KT, Tao C, Gürel S, Hong C, Zhu F, Gebke TA, et al. Effect of patient weight and scanning duration on contrast enhancement during pulmonary multidetector CT angiography. Radiology 2007;242:582–589.

    Article  PubMed  Google Scholar 

  18. Tatsugami F, Kanamoto T, Nakai G, Takeda Y, Morita H, Morinaga I, et al. Reduction of the total injection volume of contrast material with a short injection duration in 64-detector row CT coronary angiography. Br J Radiol 2010;83:35–39.

    Article  CAS  PubMed  Google Scholar 

  19. Kim DJ, Kim TH, Kim SJ, Kim DP, Oh CS, Ryu YH, et al. Saline fl ush effect for enhancement of aorta and coronary arteries at multidetector CT coronary angiography. Radiology 2008;246:110–115.

    PubMed  Google Scholar 

  20. Cademartiri F, Nieman K, van der Lugt A, Raaijmakers RH, Mollet N, Pattynama PM, et al. Intravenous contrast material administration at 16-detector row helical CT coronary angiography: test bolus versus bolus-tracking technique. Radiology 2004;233:817–823.

    Article  PubMed  Google Scholar 

  21. Bae KT. Test-bolus versus bolus-tracking techniques for CT angiographic timing. Radiology 2005;236:369–370; reply 370.

    Article  PubMed  Google Scholar 

  22. Cademartiri F, Mollet NR, Runza G, Bruining N, Hamers R, Somers P, et al. Infl uence of intracoronary attenuation on coronary plaque measurements using multislice computed tomography: observations in an ex vivo model of coronary computed tomography angiography. Eur Radiol 2005; 15:1426–1431.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Diagnostic Radiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan

    Tsuyoshi Isogai, Masahiro Jinzaki, Yutaka Tanami, Hiroyuki Kusuzaki & Sachio Kuribayashi

  2. Cardiovascular Imaging Laboratory, Research Park, Keio University School of Medicine, Tokyo, Japan

    Minoru Yamada

Authors
  1. Tsuyoshi Isogai
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  2. Masahiro Jinzaki
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  3. Yutaka Tanami
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  4. Hiroyuki Kusuzaki
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  5. Minoru Yamada
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  6. Sachio Kuribayashi
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Corresponding author

Correspondence to Masahiro Jinzaki.

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Isogai, T., Jinzaki, M., Tanami, Y. et al. Body weight-tailored contrast material injection protocol for 64-detector row computed tomography coronary angiography. Jpn J Radiol 29, 33–38 (2011). https://doi.org/10.1007/s11604-010-0514-1

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  • DOI: https://doi.org/10.1007/s11604-010-0514-1

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