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Evaluation of epirubicin-induced cardiotoxicity by two-dimensional strain echocardiography in breast cancer patients

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Summary

The value of two-dimensional strain echocardiography for assessing left ventricular regional systolic function in breast cancer patients who were treated with epirubicin was evaluated. A total of 116 breast cancer patients were divided into 3 groups: Thirty-eight patients in group A were given epirubicin (Epi) of 120–340 mg/m2, 42 patients in group B received epirubicin of ≥ 360 mg/m2, and 36 patients after surging without chemotherapy served as the control group C. High frame rate two-dimensional images were recorded from apical long-axis view, four-chamber view, two-chamber view of left ventricle. Peak systolic strain of left ventricular subendocardial myocardium was measured using two-dimensional strain software. The conventional echocardiographic parameters were also obtained. Conventional echocardiography showed there was no significant changes in conventional echocardiographic parameters among the three groups (P>0.05). Two-dimensional strain echocardiography revealed that the peak systolic strain of left ventricular subendocardial myocardium in group A was reduced in some segments as compared with the controls (P<0.05). The peak systolic strain of left ventricular subendocardial myocardium in group B was reduced significantly as compared with group C (P<0.05), but that was reduced in group B just in some of the segments as compared with group A (P<0.05). It was concluded that two-dimensional strain echocardiography could early and sensitively display the effects of epirubicin-induced cardiotoxicity on the systolic function of left ventricular subendocardial myocardium, and early monitor the epirubicin-induced cardiotoxicity.

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Authors and Affiliations

  1. Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Xiaojun Bi  (毕小军), Youbin Deng  (邓又斌), Fanjing Zeng  (曾繁静), Ying Zhu  (朱 英), Yuhan Wu  (伍玉晗), Ceyao Zhao  (赵策瑶) & Chunlei Li  (黎春雷)

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  1. Xiaojun Bi  (毕小军)
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  2. Youbin Deng  (邓又斌)
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  3. Fanjing Zeng  (曾繁静)
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  4. Ying Zhu  (朱 英)
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  5. Yuhan Wu  (伍玉晗)
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  6. Ceyao Zhao  (赵策瑶)
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  7. Chunlei Li  (黎春雷)
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Correspondence to Xiaojun Bi  (毕小军).

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Bi, X., Deng, Y., Zeng, F. et al. Evaluation of epirubicin-induced cardiotoxicity by two-dimensional strain echocardiography in breast cancer patients. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 29, 391–394 (2009). https://doi.org/10.1007/s11596-009-0326-7

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  • DOI: https://doi.org/10.1007/s11596-009-0326-7

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