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Sorting Through the Roles of Beclin 1 in Microglia and Neurodegeneration

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Abstract

Beclin 1 has a well-established role in regulating autophagy, a cellular degradation pathway. Although the yeast ortholog of beclin 1 (Atg6/Vps30) was discovered to also regulate vacuolar protein sorting nearly 30 years ago, the varied functions of beclin 1 in mammalian cells are only beginning to be sorted out. We recently described a role for beclin 1 in regulating recycling of phagocytic receptors in microglia, a function analogous to that of its yeast ortholog. Microglia lacking beclin 1 have a reduced phagocytic capacity, which impairs clearance of amyloid β (Aβ) in a mouse model of Alzheimer’s Disease (AD). Here we summarize these findings and discuss the implications for beclin 1-regulated receptor recycling in neurodegenerative disease.

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Authors and Affiliations

  1. Cell and Molecular Biology Program, Stanford University, Stanford, CA, 94305, USA

    Caitlin E. O’Brien

  2. Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA

    Caitlin E. O’Brien & Tony Wyss-Coray

  3. Center for Tissue Regeneration, Repair, and Restoration, Veterans Administration Palo Alto, Health Care System, Palo Alto, CA, 94304, USA

    Caitlin E. O’Brien & Tony Wyss-Coray

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O’Brien, C.E., Wyss-Coray, T. Sorting Through the Roles of Beclin 1 in Microglia and Neurodegeneration. J Neuroimmune Pharmacol 9, 285–292 (2014). https://doi.org/10.1007/s11481-013-9519-8

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