Abstract
Osteoporosis affects millions of individuals worldwide, rendering them susceptible to fragility fractures of the spine, hip, and wrist and leading to significant morbidity, mortality, and economic cost. Given the substantial impact of osteoporosis on both patients and the medical community, it is imperative that physicians improve awareness and knowledge of osteoporosis in the setting of low-energy fractures. In this review, we provide information on effective means of preventing fragility fractures and introduce clinicians to issues pertinent to the patient who suffers an osteoporotic fracture. Prevention of fragility fractures centers around adequate mineral nutrition, including daily calcium and vitamin D supplementation, as well as prescription antiresorptive medications such as bisphosphonates or teriparatide therapy in severe cases, both of which have been shown to decrease future fracture risk. Balance and strength training also play important roles in the management of the osteoporotic patient, particularly following a low-energy fracture, and external hip protectors may be useful for certain patients. Kyphoplasty and vertebroplasty are two minimally invasive techniques that show great promise in the treatment of vertebral compression fractures, although questions regarding long-term biomechanical effects still exist. Traditionally, osteoporosis has been underdiagnosed and undertreated following a low-energy fracture in an elderly patient. Although treatment rates may be improving through public health initiatives, the majority of patients with osteoporosis remain inadequately treated. Perioperative intervention programs that focus on patient education about osteoporosis and treatment options lead to significant increases in intervention and treatment. Reducing the risk of skeletal fractures in patients susceptible to osteoporosis involves improved physician education on the risk factors and management of osteoporosis, as well as informing patients on the significance of dual-energy X-ray absorptiometry testing and medical treatment so that they may serve as their own healthcare advocates in this often-undertreated disease.
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References
Lin JT, Lane JM (2004) Osteoporosis: a review. Clin Orthop Relat Res 126–134
NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy, March 7–29, 2000: highlights of the conference (2001) South Med J 94:569–573
Lane JM, Russell L, Khan SN (2000) Osteoporosis. Clin Orthop Relat Res 139–150
BL Riggs LJ Melton SuffixIII (1992) ArticleTitleThe prevention and treatment of osteoporosis N Engl J Med 327 620–627 Occurrence Handle1:CAS:528:DyaK3sXnt12jsg%3D%3D Occurrence Handle1640955
CW Slemenda SL Hui C Longcope H Wellman CC Johnston (1990) ArticleTitlePredictors of bone mass in perimenopausal women. A prospective study of clinical data using photon absorptiometry Ann Intern Med 112 96–101 Occurrence Handle1:STN:280:By%2BC3czjtFw%3D Occurrence Handle2294827
RBS Rosier (2002) Bone metabolism and metabolic bone diseases K Koval (Eds) Orthopaedic knowledge update 7 American Academy of Orthopaedic Surgeons Rosemont IL
BL Riggs LJ Melton SuffixIII (1995) ArticleTitleThe worldwide problem of osteoporosis: insights afforded by epidemiology Bone 17 505S–511S Occurrence Handle10.1016/8756-3282(95)00258-4 Occurrence Handle1:STN:280:BymC2cnptlA%3D Occurrence Handle8573428
LJ Melton SuffixIII (1995) Epidemiology of fractures BL Riggs LJ Melton (Eds) Osteoporosis etiology, diagnosis, and management EditionNumber2 Lippincott-Raven Philadelphia, PA 225–248
LJ Melton SuffixIII M Thamer NF Ray et al. (1997) ArticleTitleFractures attributable to osteoporosis: report from the National Osteoporosis Foundation J Bone Miner Res 12 16–23 Occurrence Handle9240721
LJ Melton SuffixIII (1995) ArticleTitleHow many women have osteoporosis now? J Bone Miner Res 10 175–177 Occurrence Handle7754796
NF Ray JK Chan M Thamer LJ Melton SuffixIII (1997) ArticleTitleMedical expenditures for the treatment of osteoporotic fractures in the United States in 1995: report from the National Osteoporosis Foundation J Bone Miner Res 12 24–35 Occurrence Handle1:STN:280:ByiA1c3ntl0%3D Occurrence Handle9240722
Cosman F (2005) The prevention and treatment of osteoporosis. Medscape Gen Med 7
WS Browner AR Pressman MC Nevitt SR Cummings (1996) ArticleTitleMortality following fractures in older women. The study of osteoporotic fractures Arch Intern Med 156 1521–1525 Occurrence Handle10.1001/archinte.156.14.1521 Occurrence Handle1:STN:280:BymB1M7it1w%3D Occurrence Handle8687260
MC Nevitt B Ettinger DM Black et al. (1998) ArticleTitleThe association of radiographically detected vertebral fractures with back pain and function: a prospective study Ann Intern Med 128 793–800 Occurrence Handle1:STN:280:DyaK1c3ktlSjsQ%3D%3D Occurrence Handle9599190
DT Gold (2001) ArticleTitleThe nonskeletal consequences of osteoporotic fractures. Psychologic and social outcomes Rheum Dis Clin North Am 27 255–262 Occurrence Handle10.1016/S0889-857X(05)70197-6 Occurrence Handle1:STN:280:DC%2BD3MzpsVClsg%3D%3D Occurrence Handle11285999
SR Cummings MC Nevitt WS Browner et al. (1995) ArticleTitleRisk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group N Engl J Med 332 767–773 Occurrence Handle10.1056/NEJM199503233321202 Occurrence Handle1:STN:280:ByqC28nislE%3D Occurrence Handle7862179
R Lindsay SL Silverman C Cooper et al. (2001) ArticleTitleRisk of new vertebral fracture in the year following a fracture JAMA 285 320–323 Occurrence Handle10.1001/jama.285.3.320 Occurrence Handle1:STN:280:DC%2BD3M7kslamtw%3D%3D Occurrence Handle11176842
KB Freedman FS Kaplan WB Bilker BL Strom RA Lowe (2000) ArticleTitleTreatment of osteoporosis: are physicians missing an opportunity? J Bone Jt Surg Am 82-A 1063–1070 Occurrence Handle1:STN:280:DC%2BD3cvjslarsQ%3D%3D
MJ Gardner KR Flik P Mooar JM Lane (2002) ArticleTitleImprovement in the undertreatment of osteoporosis following hip fracture J Bone Joint Surg Am 84-A 1342–1348 Occurrence Handle12177263
MC Chapuy ME Arlot F Duboeuf et al. (1992) ArticleTitleVitamin D3 and calcium to prevent hip fractures in the elderly women N Engl J Med 327 1637–1642 Occurrence Handle1:STN:280:ByyD28zgvVw%3D Occurrence Handle1331788
MC Chapuy ME Arlot PD Delmas PJ Meunier (1994) ArticleTitleEffect of calcium and cholecalciferol treatment for three years on hip fractures in elderly women Basic Mus J 308 1081–1082 Occurrence Handle1:STN:280:ByuB38jmsV0%3D
JA Grisso JL Kelsey BL Strom et al. (1991) ArticleTitleRisk factors for falls as a cause of hip fracture in women. The Northeast Hip Fracture Study Group N Engl J Med 324 1326–1331 Occurrence Handle1:STN:280:By6B3cvgtFM%3D Occurrence Handle2017229
C Cooper DJ Barker C Wickham (1988) ArticleTitlePhysical activity, muscle strength, and calcium intake in fracture of the proximal femur in Britain Basic Mus J 297 1443–1446 Occurrence Handle1:STN:280:BiaC3srhsVI%3D
PJ Meunier PD Delmas R Eastell et al. (1999) ArticleTitleDiagnosis and management of osteoporosis in postmenopausal women: clinical guidelines. International Committee for Osteoporosis Clinical Guidelines Clin Ther 21 1025–1044 Occurrence Handle10.1016/S0149-2918(99)80022-8 Occurrence Handle1:STN:280:DyaK1MzmslagtQ%3D%3D Occurrence Handle10440625
J Reginster HW Minne OH Sorensen et al. (2000) ArticleTitleRandomized trial of the effects of risedronate on vertebral fractures in women with established postmenopausal osteoporosis. Vertebral Efficacy with Risedronate Therapy (VERT) Study Group Osteoporos Int 11 83–91 Occurrence Handle10.1007/s001980050010 Occurrence Handle1:CAS:528:DC%2BD3cXhvFGgsr0%3D Occurrence Handle10663363
CA Wickham K Walsh C Cooper et al. (1989) ArticleTitleDietary calcium, physical activity, and risk of hip fracture: a prospective study Basic Mus J 299 889–892 Occurrence Handle1:STN:280:By%2BD2MjnvVI%3D
AM Grant A Avenell MK Campbell et al. (2005) ArticleTitleOral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial Lancet 365 1621–1628 Occurrence Handle1:STN:280:DC%2BD2M3kslClsA%3D%3D Occurrence Handle15885294
J Porthouse S Cockayne C King et al. (2005) ArticleTitleRandomised controlled trial of calcium and supplementation with cholecalciferol (vitamin D3) for prevention of fractures in primary care Basic Mus J 330 1003 Occurrence Handle1:CAS:528:DC%2BD2MXkslKlu78%3D
UA Liberman SR Weiss J Broll et al. (1995) ArticleTitleEffect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. The Alendronate Phase III Osteoporosis Treatment Study Group N Engl J Med 333 1437–1443 Occurrence Handle10.1056/NEJM199511303332201 Occurrence Handle1:CAS:528:DyaK28XkslehtA%3D%3D Occurrence Handle7477143
A Cranney G Guyatt L Griffith G Wells P Tugwell C Rosen (2002) ArticleTitleMeta-analyses of therapies for postmenopausal osteoporosis. IX: Summary of meta-analyses of therapies for postmenopausal osteoporosis Endocr Rev 23 570–578 Occurrence Handle1:CAS:528:DC%2BD38Xnt1Whs78%3D Occurrence Handle12202472
DM Black SR Cummings DB Karpf et al. (1996) ArticleTitleRandomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group Lancet 348 1535–1541 Occurrence Handle1:CAS:528:DyaK2sXisFCktQ%3D%3D Occurrence Handle8950879
DM Black DE Thompson DC Bauer et al. (2000) ArticleTitleFracture risk reduction with alendronate in women with osteoporosis: the Fracture Intervention Trial. FIT Research Group J Clin Endocrinol Metab 85 4118–4124 Occurrence Handle10.1210/jc.85.11.4118 Occurrence Handle1:CAS:528:DC%2BD3cXotlWnurw%3D Occurrence Handle11095442
HA Pols D Felsenberg DA Hanley et al. (1999) ArticleTitleMultinational, placebo-controlled, randomized trial of the effects of alendronate on bone density and fracture risk in postmenopausal women with low bone mass: results of the FOSIT study. Foxamax International Trial Study Group Osteoporos Int 9 461–468 Occurrence Handle10.1007/PL00004171 Occurrence Handle1:CAS:528:DyaK1MXkt1CktrY%3D Occurrence Handle10550467
I Fogelman C Ribot R Smith D Ethgen E Sod JY Reginster (2000) ArticleTitleRisedronate reverses bone loss in postmenopausal women with low bone mass: results from a multinational, double-blind, placebo-controlled trial. BMD-MN Study Group J Clin Endocrinol Metab 85 1895–1900 Occurrence Handle10.1210/jc.85.5.1895 Occurrence Handle1:CAS:528:DC%2BD3cXlt1Wlsb4%3D Occurrence Handle10843171
ST Harris NB Watts HK Genant et al. (1999) ArticleTitleEffects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Vertebral Efficacy with Risedronate Therapy (VERT) Study Group JAMA 282 1344–1352 Occurrence Handle10.1001/jama.282.14.1344 Occurrence Handle1:CAS:528:DyaK1MXmvFansr0%3D Occurrence Handle10527181
MR McClung P Geusens PD Miller et al. (2001) ArticleTitleEffect of risedronate on the risk of hip fracture in elderly women. Hip Intervention Program Study Group N Engl J Med 344 333–340 Occurrence Handle10.1056/NEJM200102013440503 Occurrence Handle1:CAS:528:DC%2BD3MXht1Wlu7g%3D Occurrence Handle11172164
A Peretz JJ Body JC Dumon et al. (1996) ArticleTitleCyclical pamidronate infusions in postmenopausal osteoporosis Maturitas 25 69–75 Occurrence Handle10.1016/0378-5122(96)01118-8 Occurrence Handle1:STN:280:ByiD2c3gsVQ%3D Occurrence Handle8887311
G Guttmann D Linthoudt ParticleVan (1999) ArticleTitleEfficacy of intravenous pamidronate in osteoporosis, mineralometric evaluation Schweiz Rundsch Med PRAXIS 88 2057–2060 Occurrence Handle1:STN:280:DC%2BD3c7gsl2gtA%3D%3D
IR Reid JP Brown P Burckhardt et al. (2002) ArticleTitleIntravenous zoledronic acid in postmenopausal women with low bone mineral density N Engl J Med 346 653–661 Occurrence Handle10.1056/NEJMoa011807 Occurrence Handle1:CAS:528:DC%2BD38XhsFOjsrw%3D Occurrence Handle11870242
Koivukangas A, Tuukkanen J, Kippo K et al (2003) Long-term administration of clodronate does not prevent fracture healing in rats. Clin Orthop Relat Res 268–278
DG Little MS Cornell J Briody CT Cowell S Arbuckle CM Cooke-Yarborough (2001) ArticleTitleIntravenous pamidronate reduces osteoporosis and improves formation of the regenerate during distraction osteogenesis. A study in immature rabbits J Bone Jt Surg Br 83 1069–1074 Occurrence Handle1:STN:280:DC%2BD3MrlslCntQ%3D%3D
C Gennari (2002) ArticleTitleAnalgesic effect of calcitonin in osteoporosis Bone 30 67S–70S Occurrence Handle10.1016/S8756-3282(02)00713-5 Occurrence Handle1:CAS:528:DC%2BD38Xjtl2lur4%3D Occurrence Handle12008161
MG Martens (2003) ArticleTitleRisk of fracture and treatment to prevent osteoporosis-related fracture in postmenopausal women. A review J Reprod Med 48 425–434 Occurrence Handle12856513
SL Silverman (2003) ArticleTitleCalcitonin Endocrinol Metab Clin N Am 32 273–284 Occurrence Handle10.1016/S0889-8529(02)00060-9 Occurrence Handle1:CAS:528:DC%2BD3sXjtFOjtr4%3D
JJ Body GA Gaich WH Scheele et al. (2002) ArticleTitleA randomized double-blind trial to compare the efficacy of teriparatide [recombinant human parathyroid hormone (1–34)] with alendronate in postmenopausal women with osteoporosis J Clin Endocrinol Metab 87 4528–4535 Occurrence Handle10.1210/jc.2002-020334 Occurrence Handle1:CAS:528:DC%2BD38XnvFCrsr8%3D Occurrence Handle12364430
DW Dempster F Cosman ES Kurland et al. (2001) ArticleTitleEffects of daily treatment with parathyroid hormone on bone microarchitecture and turnover in patients with osteoporosis: a paired biopsy study J Bone Miner Res 16 1846–1853 Occurrence Handle1:CAS:528:DC%2BD3MXnsVKqtLw%3D Occurrence Handle11585349
J Reeve PJ Meunier JA Parsons et al. (1980) ArticleTitleAnabolic effect of human parathyroid hormone fragment on trabecular bone in involutional osteoporosis: a multicentre trial Br Med J 280 1340–1344 Occurrence Handle1:STN:280:Bi%2BB383gtFc%3D Occurrence Handle6992932
RL Jilka RS Weinstein T Bellido P Roberson AM Parfitt SC Manolagas (1999) ArticleTitleIncreased bone formation by prevention of osteoblast apoptosis with parathyroid hormone J Clin Invest 104 439–446 Occurrence Handle1:CAS:528:DyaK1MXltlekur8%3D Occurrence Handle10449436
RM Neer CD Arnaud JR Zanchetta et al. (2001) ArticleTitleEffect of parathyroid hormone (1–34) on fractures and bone mineral density in postmenopausal women with osteoporosis N Engl J Med 344 1434–1441 Occurrence Handle10.1056/NEJM200105103441904 Occurrence Handle1:CAS:528:DC%2BD3MXktVSgsbw%3D Occurrence Handle11346808
DM Black SL Greenspan KE Ensrud et al. (2003) ArticleTitleThe effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis N Engl J Med 349 1207–1215 Occurrence Handle10.1056/NEJMoa031975 Occurrence Handle1:CAS:528:DC%2BD3sXns1Kmsrw%3D Occurrence Handle14500804
JS Finkelstein A Hayes JL Hunzelman JJ Wyland H Lee RM Neer (2003) ArticleTitleThe effects of parathyroid hormone, alendronate, or both in men with osteoporosis N Engl J Med 349 1216–1226 Occurrence Handle1:CAS:528:DC%2BD3sXns1Kmsrs%3D Occurrence Handle14500805
R. Lindsay F Cosman (2003) Estrogen-dependent bone loss and osteoporosis E Orwell (Eds) Atlas of osteoporosis Current Medicine Philadelphia, PA 95–104
R Lindsay DM Hart C Forrest C Baird (1980) ArticleTitlePrevention of spinal osteoporosis in oophorectomised women Lancet 2 1151–1154 Occurrence Handle1:STN:280:Bi6D2M7jsFA%3D Occurrence Handle6107766
EG Lufkin HW Wahner WM O'Fallon et al. (1992) ArticleTitleTreatment of postmenopausal osteoporosis with transdermal estrogen Ann Intern Med 117 1–9 Occurrence Handle1:STN:280:By2B1c7is1I%3D Occurrence Handle1534476
JE Rossouw GL Anderson RL Prentice et al. (2002) ArticleTitleRisks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial JAMA 288 321–333 Occurrence Handle1:CAS:528:DC%2BD38Xltlegs7k%3D Occurrence Handle12117397
GL Anderson M Limacher AR Assaf et al. (2004) ArticleTitleEffects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial JAMA 291 1701–1712 Occurrence Handle1:CAS:528:DC%2BD2cXjt1WktLw%3D Occurrence Handle15082697
M Maricic JD Adachi S Sarkar W Wu M Wong KD Harper (2002) ArticleTitleEarly effects of raloxifene on clinical vertebral fractures at 12 months in postmenopausal women with osteoporosis Arch Intern Med 162 1140–1143 Occurrence Handle10.1001/archinte.162.10.1140 Occurrence Handle1:CAS:528:DC%2BD38XksFWksbw%3D Occurrence Handle12020184
KC Morello GT Wurz MW DeGregorio (2002) ArticleTitleSERMs: current status and future trends Crit Rev Oncol Hematol 43 63–76 Occurrence Handle12098608
P Kannus J Parkkari S Niemi et al. (2000) ArticleTitlePrevention of hip fracture in elderly people with use of a hip protector N Engl J Med 343 1506–1513 Occurrence Handle10.1056/NEJM200011233432101 Occurrence Handle1:STN:280:DC%2BD3M%2FjsVSjsw%3D%3D Occurrence Handle11087879
Mm Hubacher A Wettstein (2001) ArticleTitleAcceptance of hip protectors for hip fracture prevention in nursing homes Osteoporos Int 12 794–799 Occurrence Handle10.1007/s001980170057 Occurrence Handle1:STN:280:DC%2BD3MrlvFekuw%3D%3D Occurrence Handle11605747
ID Cameron B Stafford RG Cumming et al. (2000) ArticleTitleHip protectors improve falls self-efficacy Age Ageing 29 57–62 Occurrence Handle10.1093/ageing/29.1.57 Occurrence Handle1:STN:280:DC%2BD3c7lt1GmtA%3D%3D Occurrence Handle10690697
Aharonoff GB, Dennis MG, Elshinawy A, Zuckerman JD, Koval KJ (1998) Circumstances of falls causing hip fractures in the elderly. Clin Orthop Relat Res 10–14
BE Maki PJ Holliday AK Topper (1994) ArticleTitleA prospective study of postural balance and risk of falling in an ambulatory and independent elderly population J Gerontol 49 M72–M84 Occurrence Handle1:STN:280:ByuC2s3itFA%3D Occurrence Handle8126355
SL Wolf HX Barnhart NG Kutner E McNeely C Coogler T Xu (1996) ArticleTitleReducing frailty and falls in older persons: an investigation of Tai Chi and computerized balance training. Atlanta FICSIT Group. Frailty and Injuries: Cooperative Studies of Intervention Techniques J Am Geriatr Soc 44 489–497 Occurrence Handle1:STN:280:BymB3cfovFw%3D Occurrence Handle8617895
AM Wong YC Lin SW Chou FT Tang PY Wong (2001) ArticleTitleCoordination exercise and postural stability in elderly people: Effect of Tai Chi Chuan Arch Phys Med Rehabil 82 608–612 Occurrence Handle10.1053/apmr.2001.22615 Occurrence Handle1:STN:280:DC%2BD3M3ltVKgsg%3D%3D Occurrence Handle11346836
YC Lin AM Wong SW Chou FT Tang PY Wong (2000) ArticleTitleThe effects of Tai Chi Chuan on postural stability in the elderly: preliminary report Chang Gung Med J 23 197–204 Occurrence Handle1:STN:280:DC%2BD3czmtVKrsw%3D%3D Occurrence Handle10902224
JT Lin JM Lane (2002) ArticleTitleNonmedical management of osteoporosis Curr Opin Rheumatol 14 441–446 Occurrence Handle10.1097/00002281-200207000-00019 Occurrence Handle12118182
CM Snow JM Shaw KM Winters KA Witzke (2000) ArticleTitleLong-term exercise using weighted vests prevents hip bone loss in postmenopausal women J Gerontol Ser A Biol Sci Med Sci 55 M489–M491 Occurrence Handle1:STN:280:DC%2BD3cvksVKksw%3D%3D
J Iwamoto T Takeda S Ichimura (2001) ArticleTitleEffect of exercise training and detraining on bone mineral density in postmenopausal women with osteoporosis J Orthop Sci 6 128–132 Occurrence Handle1:STN:280:DC%2BD3MvjsFyjsg%3D%3D Occurrence Handle11484097
LL Seeger (1997) ArticleTitleBone density determination Spine 22 49S–57S Occurrence Handle10.1097/00007632-199712151-00009 Occurrence Handle1:STN:280:DyaK1c%2FptlOisQ%3D%3D Occurrence Handle9431645
LJ Melton SuffixIII (1997) ArticleTitleEpidemiology of spinal osteoporosis Spine 22 2S–11S Occurrence Handle10.1097/00007632-199712151-00002 Occurrence Handle9431638
InstitutionalAuthorNameNational Osteoporosis Foundation (2003) Physician's guide to prevention and treatment of osteoporosis National Osteoporosis Foundation Washington, DC
DJ Torgerson P Dolan (1998) ArticleTitlePrescribing by general practitioners after an osteoporotic fracture Ann Rheum Dis 57 378–379 Occurrence Handle1:STN:280:DyaK1cvksVWmtg%3D%3D Occurrence Handle9771215
AA Abbasi D Rudman CR Wilson et al. (1995) ArticleTitleObservations on nursing home residents with a history of hip fracture Am J Med Sci 310 229–234 Occurrence Handle1:STN:280:BymC3c7jsVc%3D Occurrence Handle7503102
MJ Gardner RH Brophy D Demetrakopoulos et al. (2005) ArticleTitleInterventions to improve osteoporosis treatment following hip fracture. A prospective, randomized trial J Bone Jt Surg Am 87 3–7
GM Kiebzak GA Beinart K Perser CG Ambrose SJ Siff MH Heggeness (2002) ArticleTitleUndertreatment of osteoporosis in men with hip fracture Arch Intern Med 162 2217–2222 Occurrence Handle10.1001/archinte.162.19.2217 Occurrence Handle12390065
MD Smith W Ross MJ Ahern (2001) ArticleTitleMissing a therapeutic window of opportunity: an audit of patients attending a tertiary teaching hospital with potentially osteoporotic hip and wrist fractures J Rheumatol 28 2504–2508 Occurrence Handle1:STN:280:DC%2BD3Mnmt1yjsw%3D%3D Occurrence Handle11708425
KF Mauck MT Cuddihy RT Trousdale GR Pond VS Pankratz LJ Melton SuffixIII (2002) ArticleTitleThe decision to accept treatment for osteoporosis following hip fracture: exploring the woman's perspective using a stage-of-change model Osteoporos Int 13 560–564 Occurrence Handle10.1007/s001980200073 Occurrence Handle1:STN:280:DC%2BD38zmslSmsw%3D%3D Occurrence Handle12111016
G Phillipov PJ Phillips G Leach AW Taylor (1998) ArticleTitlePublic perceptions and self-reported prevalence of osteoporosis in South Australia Osteoporos Int 8 552–556 Occurrence Handle10.1007/s001980050098 Occurrence Handle1:STN:280:DyaK1M3lsl2isg%3D%3D Occurrence Handle10326060
C Simonelli K Killeen S Mehle L Swanson (2002) ArticleTitleBarriers to osteoporosis identification and treatment among primary care physicians and orthopedic surgeons Mayo Clin Proc 77 334–338 Occurrence Handle11936928
AC Feldstein GA Nichols PJ Elmer DH Smith M Aickin M Herson (2003) ArticleTitleOlder women with fractures: patients falling through the cracks of guideline-recommended osteoporosis screening and treatment J Bone Jt Surg Am 85-A 2294–2302
NS Ali KR Twibell (1994) ArticleTitleBarriers to osteoporosis prevention in perimenopausal and elderly women Geriatr Nurs 15 201–205 Occurrence Handle1:STN:280:ByuA3MvisFQ%3D Occurrence Handle8039734
SB Jaglal WJ McIsaac G Hawker et al. (2003) ArticleTitleInformation needs in the management of osteoporosis in family practice: an illustration of the failure of the current guideline implementation process Osteoporos Int 14 672–676 Occurrence Handle12879224
JC Taylor B Sterkel M Utley et al. (2001) ArticleTitleOpinions and experiences in general practice on osteoporosis prevention, diagnosis and management Osteoporos Int 12 844–848 Occurrence Handle10.1007/s001980170035 Occurrence Handle1:STN:280:DC%2BD3MnntVCntw%3D%3D Occurrence Handle11716187
LA Bero R Grilli JM Grimshaw E Harvey AD Oxman MA Thomson (1998) ArticleTitleClosing the gap between research and practice: an overview of systematic reviews of interventions to promote the implementation of research findings. The Cochrane Effective Practice and Organization of Care Review Group Basic Mus J 317 465–468 Occurrence Handle1:STN:280:DyaK1czmvV2htQ%3D%3D
R Thomson M Lavender R Madhok (1995) ArticleTitleHow to ensure that guidelines are effective Basic Mus J 311 237–242 Occurrence Handle1:STN:280:ByqA2Mzht10%3D
KW Lyles DT Gold KM Shipp CF Pieper S Martinez PL Mulhausen (1993) ArticleTitleAssociation of osteoporotic vertebral compression fractures with impaired functional status Am J Med 94 595–601 Occurrence Handle10.1016/0002-9343(93)90210-G Occurrence Handle1:STN:280:ByyB1c3ktlA%3D Occurrence Handle8506884
AJ Evans ME Jensen KE Kip et al. (2003) ArticleTitleVertebral compression fractures: pain reduction and improvement in functional mobility after percutaneous polymethylmethacrylate vertebroplasty retrospective report of 245 cases Radiology 226 366–372 Occurrence Handle12563127
JT Ledlie M Renfro (2003) ArticleTitleBalloon kyphoplasty: one-year outcomes in vertebral body height restoration, chronic pain, and activity levels J Neurosurg 98 36–42 Occurrence Handle12546386
JM Mathis JD Barr SM Belkoff MS Barr ME Jensen H Deramond (2001) ArticleTitlePercutaneous vertebroplasty: a developing standard of care for vertebral compression fractures AJNR Am J Neuroradiol 22 373–381 Occurrence Handle1:STN:280:DC%2BD3M7ntFCmsA%3D%3D Occurrence Handle11156786
FM Phillips E Ho M Campbell-Hupp T McNally F Todd Wetzel P Gupta (2003) ArticleTitleEarly radiographic and clinical results of balloon kyphoplasty for the treatment of osteoporotic vertebral compression fractures Spine 28 2260–2265 Occurrence Handle10.1097/00007632-200303150-00011 Occurrence Handle14520041
HD Deramond C Depriester P Galibert D Gars ParticleLe (1998) ArticleTitlePercutaneous vertebroplasty with polymethylmethacrylate: technique, indications, and results Radiol Clin North Am 36 533–546 Occurrence Handle10.1016/S0033-8389(05)70042-7 Occurrence Handle1:STN:280:DyaK1c3lvFemuw%3D%3D Occurrence Handle9597071
PW Heini B Walchli B Heini U Berlemann (2000) ArticleTitlePercutaneous transpedicular vertebroplasty with PMMA: operative technique and early results: a prospective study for the treatment of osteoporotic compression fractures Eur Spine J 9 445–450 Occurrence Handle10.1007/s005860000182 Occurrence Handle1:STN:280:DC%2BD3crgsFykug%3D%3D Occurrence Handle11057541
BJ Bai LM Jazrawi FJ Kummer JM Spivak (1999) ArticleTitleThe use of an injectable, biodegradable calcium phosphate bone substitute for the prophylactic augmentation of osteoporotic vertebrae and the management of vertebral compression fractures Spine 24 1521–1526 Occurrence Handle10.1097/00007632-199908010-00004 Occurrence Handle1:STN:280:DyaK1Mzos1Shsg%3D%3D Occurrence Handle10457570
JD Barr (2002) ArticleTitlePoint of view: An in vivo comparison of the potential for extravertebral cement leak after vertebroplasty and kyphoplasty Spine 27 2178–2179 Occurrence Handle10.1097/00007632-200210010-00019
NB Watts ST Harris HK Genant (2001) ArticleTitleTreatment of painful osteoporotic vertebral fractures with percutaneous vertebroplasty or kyphoplasty Osteoporos Int 12 429–437 Occurrence Handle1:STN:280:DC%2BD3Mzpt1eguw%3D%3D Occurrence Handle11446557
MA Donovan AG Khandji E Siris (2004) ArticleTitleMultiple adjacent vertebral fractures after kyphoplasty in a patient with steroid-induced osteoporosis J Bone Miner Res 19 712–713 Occurrence Handle15070449
IH Lieberman S Dudeney MK Reinhardt G Bell (2001) ArticleTitleInitial outcome and efficacy of “kyphoplasty” in the treatment of painful osteoporotic vertebral compression fractures Spine 26 1631–1638 Occurrence Handle10.1097/00007632-200107150-00026 Occurrence Handle1:STN:280:DC%2BD3Mvhtl2rsg%3D%3D Occurrence Handle11464159
S Dudeney IH Lieberman MK Reinhardt M Hussein (2002) ArticleTitleKyphoplasty in the treatment of osteolytic vertebral compression fractures as a result of multiple myeloma J Clin Oncol 20 2382–2387 Occurrence Handle10.1200/JCO.2002.09.097 Occurrence Handle1:STN:280:DC%2BD383ktlertA%3D%3D Occurrence Handle11981012
DJ Theodorou SJ Theodorou TD Duncan SR Garfin WH Wong (2002) ArticleTitlePercutaneous balloon kyphoplasty for the correction of spinal deformity in painful vertebral body compression fractures Clin Imaging 26 1–5 Occurrence Handle11814744
Liberman IR, Reinhardt MK (2003) Vertebroplasty and kyphoplasty for osteolytic vertebral collapse. Clin Orthop Relat Res S176–S186
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Gardner, M.J., Demetrakopoulos, D., Shindle, M.K. et al. Osteoporosis and Skeletal Fractures. HSS Jrnl 2, 62–69 (2006). https://doi.org/10.1007/s11420-005-0137-8
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DOI: https://doi.org/10.1007/s11420-005-0137-8