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Risk of sleep-disordered breathing in Parkinson's disease

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Abstract

Objective

The objective of this study is to assess the risk of sleep-disordered breathing (SDB) in patients with Parkinson's disease (PD) in a cross-sectional survey of PD subjects and controls in a university-based movement disorders clinic.

Methods

One hundred thirty-four consecutive PD subjects and 94 control subjects without prior diagnosis of SDB were assessed. Participants were assessed with clinical history, Unified Parkinson's Disease Rating Scale, Geriatric Depression Scale, Berlin Questionnaire to classify SDB risk, Epworth Sleepiness Scale, Parkinson's Disease Sleep Scale, and SF-36 to examine quality of life. The presence of risk for SDB was assessed by the Berlin Questionnaire.

Results

High risk for SDB was apparent in 66 (49.3%) of the PD patients and 32 (34.8%) of the controls. After adjustment for age, gender, and body mass index (BMI), PD subjects in comparison to controls showed higher risk for SBD (odds ratio = 2.81; 95% confidence interval, 1.36–5.82). Quality of life (physical component score) was significantly diminished in PD patients at high risk for SDB. PD severity did not correlate well with SDB risk. PD patients at high risk for SDB had higher BMIs and Epworth scores.

Conclusions

PD patients have features suggesting increased risk for SDB. This frequently undiagnosed sleep disorder may have a substantial impact on quality of life of PD patients.

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Acknowledgements

The authors thank the patients and staff of the University of Michigan Movement Disorders Clinic, Ann Arbor, MI, USA, for their participation and help in this survey; Dr. Ninith V. Kartha, Dr. Kelvin L. Chou, and Dr. Kirk A. Frey for their help in recruitment of the participants; and Brady T. West and Kenneth E. Guire for statistical consultation. Dr. Chotinaiwattarakul's effort was funded by Siriraj Hospital, Mahidol University, Bangkok, Thailand. This study was also supported by NS15655 and the Michael J. Fox Foundation. All authors had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

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Authors and Affiliations

  1. Sleep Disorders Center and Department of Neurology, University of Michigan, 1500 E. Medical Center Dr., Ann Arbor, MI, 48109, USA

    Wattanachai Chotinaiwattarakul & Ronald D. Chervin

  2. Movement Disorders Clinic and Department of Neurology, University of Michigan, 1500 E. Medical Center Dr., Ann Arbor, MI, 48109, USA

    Praveen Dayalu & Roger L. Albin

  3. Geriatrics Research, Education, and Clinical Center, VAAAHS, 2215 Fuller Rd., Ann Arbor, MI, 48105, USA

    Roger L. Albin

  4. 5023 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA

    Roger L. Albin

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  1. Wattanachai Chotinaiwattarakul
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  2. Praveen Dayalu
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  3. Ronald D. Chervin
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  4. Roger L. Albin
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Correspondence to Roger L. Albin.

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Chotinaiwattarakul, W., Dayalu, P., Chervin, R.D. et al. Risk of sleep-disordered breathing in Parkinson's disease. Sleep Breath 15, 471–478 (2011). https://doi.org/10.1007/s11325-010-0362-3

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  • DOI: https://doi.org/10.1007/s11325-010-0362-3

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