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Image-Derived Input Function from Cardiac Gated Maximum a Posteriori Reconstructed PET Images in Mice

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Abstract

Purpose

The purpose of this study was to determine if accurate image-derived input functions (IDIF) can be measured from cardiac gated positron emission tomography (PET) images reconstructed using ordered subset expectation maximization–maximum a posteriori (OSEM-MAP) without further correction.

Procedures

IDIFs from the left ventricle were measured from cardiac gated PET images reconstructed using OSEM-MAP with computed tomography (CT)-based attenuation correction for five C57/BL6 mice. The accuracy of the IDIF was tested against blood samples using Bland–Altman analysis.

Results

Image-derived blood radioactivity concentration values were not significantly different from sampled blood values at two late time points as determined by a paired t test (P = 0.97). Bland–Altman analysis revealed a mean difference of 0.06 μCi/ml (1%). Using kinetic analysis, the mean myocardial 2-deoxy-2-[18F]fluoro-d-glucose uptake rate constant based on the IDIF was comparable to values reported in the literature based on physical blood sampling.

Conclusions

Accurate IDIFs can be obtained non-invasively. Although reconstruction times are increased, no further spillover corrections are necessary for IDIFs derived from gated, OSEM-MAP reconstructed images with attenuation correction.

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Acknowledgment

This work was supported in part by the Jeffress Grant, J-899 from the Jeffress Memorial Trust, the Partners fund from the University of Virginia Cardiovascular Research Center, and NIH grant 1R21HL102627 to BKK. The work was also supported in part by a gift provided by Philip Morris USA (the review and approval process was overseen by an External Advisory Committee without any affiliation with the University, PMUSA, or any other tobacco company. PMUSA funding for this work to SSB was based upon independent intramural and extramural reviews). The authors thank Gina Wimer for her assistance with the experiments.

Conflict of interest disclosure

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Biomedical Engineering, The University of Virginia, P.O. Box 801339, 480 Ray C Hunt Drive, Snyder Building, Charlottesville, VA, 22908, USA

    Landon W. Locke & Stuart S. Berr

  2. Department of Radiology, The University of Virginia, P.O. Box 801339, 480 Ray C Hunt Drive, Snyder Building, Charlottesville, VA, 22908, USA

    Stuart S. Berr & Bijoy K. Kundu

Authors
  1. Landon W. Locke
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  2. Stuart S. Berr
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  3. Bijoy K. Kundu
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Correspondence to Bijoy K. Kundu.

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Locke, L.W., Berr, S.S. & Kundu, B.K. Image-Derived Input Function from Cardiac Gated Maximum a Posteriori Reconstructed PET Images in Mice. Mol Imaging Biol 13, 342–347 (2011). https://doi.org/10.1007/s11307-010-0347-4

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  • DOI: https://doi.org/10.1007/s11307-010-0347-4

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