Skip to main content

Advertisement

SpringerLink
Log in

Genomic sequence of an antigenic variant Newcastle disease virus isolated in Korea

  • Original Article
  • Published:
Virus Genes Aims and scope Submit manuscript

Abstract

In Korea, extensive Newcastle disease (ND) vaccine programs have been implemented, but ND outbreaks continue to occur occasionally, even in well-vaccinated farms. KBNP-4152 is a virulent ND virus, which has been isolated from vaccinated chickens in Korea. In this study, we conducted a comparison of the antigenicity of KBNP-4152 with that of a vaccine strain, La Sota, via virus-neutralization (VN) and cross haemagglutination-inhibition (HI) tests, and analyzed the genomic sequences. The antigenicity of KBNP-4152 was distinct from La Sota, and the expected genome size was 15,192 nt, as was the case with other recent virulent ND viruses analyzed. Based on the partial F gene, the strain was phylogenetically classified into the VIId genotype, but was distinct from other VII viruses due to amino acid changes at (E347K) and proximal to (M354K), the major linear epitope of HN, as well as relatively low amino acid similarity of the V protein, and a truncated W protein (203 aa vs. 227 aa). Therefore, KBNP-4152 is unique among genotype VII.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. M.A. Mayo, Arch. Virol. 147, 1071 (2002)

    Article  CAS  Google Scholar 

  2. D.J. Alexander, in A Laboratory Manual for the Isolation and Identification of Avian Pathogens, ed. by H.G. Purchase, L.H. Arp, C.H. Domermuth, J.E. Pearson (American Association of Avian Pathologists, Kennett Square, PA, 1989), pp. 114–120

  3. N.S. Millar, P.T. Emmerson, in Newcastle Disease, ed. by D.J. Alexander (Kluwer, Boston, 1988), pp. 79–97

  4. M.S. Collins, J.B. Bashiruddin, D.J. Alexander, Arch. Virol. 128, 363 (1993)

    Article  CAS  Google Scholar 

  5. Z. Huang, S. Krishnamurthy, A. Panda, S.K. Samal, J. Virol. 77, 8676 (2003)

    Article  CAS  Google Scholar 

  6. M. Steward, I.B. Vipond, N.S. Millar, P.T. Emmerson, J. Gen. Virol. 74, 2539 (1993)

    Article  CAS  Google Scholar 

  7. T. Mebatsion, L.T.C. de Vaan, N. de Haas, A. Römer-Oberdörfer, M. Braber, J. Virol. 77, 9259 (2003)

    Article  CAS  Google Scholar 

  8. B. Lomniczi, E. Wehmann, J. Herczeg, A. Ballagi-Pordány, E.F. Kaleta, O. Werner, G. Meulemans, P.H. Jorgensen, A.P. Mante, A.L.J. Gielkens, I. Capua, J. Damoser, Arch. Virol. 143, 49 (1998)

    Article  CAS  Google Scholar 

  9. J. Herczeg, E. Wehmann, R.R. Bragg, P.M. Travassos Dias, G. Hadjiev, O. Werner, B. Lomniczi, Arch. Virol. 144, 2087 (1999)

    Article  CAS  Google Scholar 

  10. C.Y. Yang, H.K. Shieh, Y.L. Lin, P.C. Chang, Avian Dis. 43, 125 (1999)

    Article  CAS  Google Scholar 

  11. H.J. Kwon, S.H. Cho, Y.J. Ahn, S.H. Seo, K.S. Choi, S.J. Kim, Vet. Microbiol. 95, 39 (2003)

    Article  CAS  Google Scholar 

  12. X.F. Liu, H.Q. Wan, X.X. Ni, Y.T. Wu, W.B. Liu, Arch. Virol. 148, 1387 (2003)

    CAS  PubMed  Google Scholar 

  13. H.J. Tsai, K.H. Chang, C.H. Tseng, K.M. Frost, R.J. Manvell, D.J. Alexander, Vet. Microbiol. 104, 19 (2004)

    Article  CAS  Google Scholar 

  14. J. Zou, S. Shan, N. Yao, Z. Gong, Virus Gen. 30, 13 (2005)

    Article  CAS  Google Scholar 

  15. A. Czeglédi, D. Ujvári, E. Somogyi, E. Wehmann, O. Werner, B. Lomniczi, Virus Res. 120, 36 (2006)

    Article  Google Scholar 

  16. D. Ujvári, Virus Gen. 32, 49 (2006)

    Article  Google Scholar 

  17. P.H. Russell, D.J. Alexander, Arch. Virol. 75, 243 (1983)

    Article  CAS  Google Scholar 

  18. R.M. Iorio, J.B. Borgman, R.L. Glickman, M.A. Bratt, J. Gen. Virol. 67, 1393 (1986)

    Article  CAS  Google Scholar 

  19. B. Gotoh, T. Sakaguchi, K. Nishikawa, N.M. Inocencio, M. Hamaguchi, T. Toyoda, Y. Nagai, Virology 163, 174 (1988)

    Article  CAS  Google Scholar 

  20. R.M. Iorio, R.J. Syddall, J.P. Sheehan, M.A. Bratt, R.L. Glickman, A.M. Riel, J. Virol. 65, 4999 (1991)

    CAS  PubMed  PubMed Central  Google Scholar 

  21. H.J. Kwon, PhD Thesis, Seoul National University (2000)

  22. D.J. Alexander, J.S. Mackenzie, P.H. Russell, Aus. Vet. J. 63, 365 (1986)

    Article  CAS  Google Scholar 

  23. D.J. Alexander, R.J. Manvell, P.A. Kemp, G. Parsons, M.S. Collins, S. Brackman, P.H. Russell, S.A. Lister, Avian Pathol. 16, 553 (1987)

    Article  CAS  Google Scholar 

  24. I. Archetti, F.L. Horsfall, J. Exp. Med. 92, 441 (1950)

    Article  CAS  Google Scholar 

  25. S. Kumar, K. Tamura, M. Nei, Brief. Bioinform. 5, 150 (2004)

    Article  CAS  Google Scholar 

  26. N. Guex, M.C. Peitsch, Electrophoresis 18, 2714 (1997)

    Article  CAS  Google Scholar 

  27. D.J. Alexander, R.J. Manvell, J.P. Lowings, K.M. Frost, M.S. Collins, P.H. Russell, J.E. Smith, Avian Pathol. 26, 399 (1997)

    Article  CAS  Google Scholar 

  28. A. Panshin, E. Shihmanter, Y. Weisman, C. Örvell, M. Lipkind, Comp. Immunol. Microbiol. Infect. Dis. 25, 173 (2002)

    Article  CAS  Google Scholar 

  29. D.J. Alexander, G. Campbell, R.J. Manvell, M.S. Collins, G. Parsons, M.S. McNulty, Vet. Rec. 130, 65 (1992)

    Article  CAS  Google Scholar 

  30. D.J. Alexander, R.J. Manvell, J. Banks, M.S. Collins, G. Parsons, B. Cox, K.M. Frost, E.C. Speidel, S. Ashman, E.W. Aldous, Avian Pathol. 28, 501 (1999)

    Article  CAS  Google Scholar 

  31. P. Roy, A.T. Venugopalan, R. Manvell, Vet. Res. Commun. 24, 135 (2000)

    Article  CAS  Google Scholar 

  32. E. Shihmanter, A. Panshin, C. Orvell, Y. Weisman, M. Lipkind, Annual Meeting of the Israel Society of Microbiology, Tel Aviv, 20–23 January, 1997, p. 96

  33. C.Y. Yang, P.C. Chang, J.M. Kwang, H.K. Shieh, Avian Dis. 41, 365 (1997)

    Article  CAS  Google Scholar 

  34. L. Yu, Z. Wang, Y. Jiang, L. Chang, J. Kwang, J. Clin. Microbiol. 39, 3512 (2001)

    Article  CAS  Google Scholar 

  35. D.J. Alexander, P.H. Russell, M.S. Collins, Vet. Rec. 114, 444 (1984)

    Article  CAS  Google Scholar 

  36. T. Morrison, A. Portner, in The Paramyxoviruses, ed. by D.W. Kingsbury (Plenum Press, New York, 1991), pp. 347–482

  37. R.M. Iorio, R.L. Glickman, A.M. Riel, J.P. Sheehan, M.A. Bratt, Virus Res. 13, 245 (1989)

    Article  CAS  Google Scholar 

  38. A.C. Samson, M. Nesbit, A.M. Lyon, G. Meulemans, J. Gen. Virol. 69, 473 (1988)

    Article  CAS  Google Scholar 

  39. S. Crennell, T. Takimoto, A. Portner, G. Taylor, Nat. Struct. Biol. 7, 1068 (2000)

    Article  CAS  Google Scholar 

  40. T.L. Bousse, G. Taylor, S. Krishnamurthy, A. Portner, S.K. Samal, T. Takimoto, J. Virol. 78, 13351 (2004)

    Article  CAS  Google Scholar 

  41. A. Kato, K. Kiyotani, M.K. Hasan, T. Shioda, Y. Sakai, T. Yoshida, Y. Nagai, J. Virol. 73, 9237 (1999)

    CAS  PubMed  PubMed Central  Google Scholar 

  42. S. Finke, J.H. Cox, K.K. Conzelmann, J. Virol. 74, 7261 (2000)

    Article  CAS  Google Scholar 

  43. J.C. Rassa, G.M. Wilson, G.A. Brewer, G.D. Parks, Virology 274, 438 (2000)

    Article  CAS  Google Scholar 

  44. M.E. Peeples, in Newcastle Disease, ed. by D.J. Alexander (Kluwer Academic Publishers, Boston, 1988), p. 53

  45. D.F. Young, N. Chatziandreou, B. He, S. Goodbourn, R.A. Lamb, R.E. Randall, J. Virol. 75, 3363 (2001)

    Article  CAS  Google Scholar 

  46. N. Chatziandreou, D. Young, J. Andrejeva, S. Goodbourn, R.E. Randall, Virology 293, 234 (2002)

    Article  CAS  Google Scholar 

  47. E. Wansley, G.D. Parks, J. Virol. 76, 10109 (2002)

    Article  CAS  Google Scholar 

  48. B. Lomniczi, J. Interferon Cytokine Res. 18, 399 (1973)

    Google Scholar 

  49. C. Park, M.J. Lecomte, C. Schindler, Nucleic Acids Res. 27, 4191 (1999)

    Article  CAS  Google Scholar 

  50. M. Paulson, S. Pisharody, L. Pan, S. Guadagno, A.L. Mui, D.E. Levy, J. Biol. Chem. 274, 25343 (1999)

    Article  CAS  Google Scholar 

  51. J.P. Parisien, J.F. Lau, C.M. Horvath, J. Virol. 76, 6435 (2002)

    Article  CAS  Google Scholar 

  52. M.S. Park, A. García-Sastre, J.F. Cros, C.F. Basler, P. Palese, J. Virol. 77, 9522 (2003)

    Article  CAS  Google Scholar 

Download references

Acknowledgment

This study was supported by the Technology Development Program of the Ministry of Agriculture and Forestry, Korea.

Author information

Authors and Affiliations

  1. Laboratory of Avian Diseases, College of Veterinary Medicine and BK21 for Veterinary Science, Seoul National University, Seoul, 151-742, Korea

    Sun-Hee Cho & Sun-Joong Kim

  2. Laboratory of Influenza virus Zoonotic Disease Institute (ZooDI), College of Veterinary Medicine and BK21 for Veterinary Science, Seoul National University, San 56-1, Shillim-Dong, Gwanak-Gu, Seoul, 151-742, Korea

    Sun-Joong Kim & Hyuk-Joon Kwon

Authors
  1. Sun-Hee Cho
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sun-Joong Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hyuk-Joon Kwon
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hyuk-Joon Kwon.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cho, SH., Kim, SJ. & Kwon, HJ. Genomic sequence of an antigenic variant Newcastle disease virus isolated in Korea. Virus Genes 35, 293–302 (2007). https://doi.org/10.1007/s11262-007-0078-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11262-007-0078-z

Keywords

Search

Navigation