Abstract
We report a case of a urothelial carcinoma with trophoblastic differentiation of the bladder that occured in a 23-year-old man. The patient presented with hematuria. Multiple papillary masses were resected transurethrally. Histopathologically, grade III urothelial cell carcinoma contained giant cells that were positive for human chorionic gonadotrophin (HCG), placental alkalen phosphatase, and human placental lactogen. HCG secreting tumors are reported to be highly aggressive. The patient is alive and well without evidence of recurrent disease or metastasis at 10 months from transurethral resection. To our knowledge, this case is the youngest patient in the literature so far.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
E Campo F Algaba A Palacin et al. (1989) ArticleTitlePlacental proteins in high-grade urothelial neoplasms. An immunohistochemical study of human chorionic gonadotropin, human placental lactogen, and pregnancy-specific beta-1-glycoprotein Cancer 63 2497–2504
D Grammatico DJ Grignon P Eberwein et al. (1993) ArticleTitleTransitional cell carcinoma of the renal pelvis with choriocarcinomatous differentiation. Immunohistochemical and immunoelectron microscopic assessment of human chorionic gonadotrophin production by transitional cell carcinoma of the urinary bladder Cancer 71 1835–1841
RS Wurzel HT Yamase PT N\ieh (1987) ArticleTitleEctopic production of human chorionic gonadotropin by poorly differentiated transitional cell tumors of the urinary tract J Urol 137 502–504
S Yokoyama Y Hayashida J Nagahama et al. (1992) ArticleTitlePrimary and metaplastic choriocarcinoma of the bladder. A report of two cases Acta Cytol 36 176–182
A Zetti MA Konrad S Polzin et al. (2002) ArticleTitleUrothelial carcinoma of the renal pelvis with choriocarcinomatous features: genetic evidence of clonal evolution Hum Pathol 33 1234–1237
K Jindrak JF Bochetto LI Alpert (1976) ArticleTitlePrimary gastric choriocarcinoma: case report with review of world literature Hum Pathol 7 595–604
JA Obe N Rosen LG Koss (1983) ArticleTitlePrimary choriocarcinoma of the urinary bladder: report of a case with probably epithelial origin Cancer 52 1405–1409
RE Fernandez PG Suarez GI Rodriguez et al. (2002) ArticleTitleBladder choriocarcinoma: retrospective analysis of the dedifferentiation of a transitional-cell papillary bladder carcinoma Arch Esp Urol 55 556–559
M Moldovsy A Sazbon N Kuchersky et al. (1998) ArticleTitleScreening for transitional cell carcinoma of the bladder with trophoblastic differentiation in Upper Galilee Harefuah 134 IssueID4 260–263
JE Martin BJ Jenkins RJ Zuk et al. (1989) ArticleTitleHuman chorionic gonadotropin expression and histological findings as predictors of response to radiotherapy in carcinoma of the bladder Virhows Arch [A] 414 273–277
F Dexeus C Logothetis E Hossan et al. (1986) ArticleTitleCarcinoembryonic antigen and beta-human chorionic gonadotropin as serum markers for advanced urothelial malignancies J Urol 136 403–407
VM Shah J Newman J Crocker et al. (1986) Ectopic β-human chorionic gonadotropin production by bladder urothelial neoplasia Arch Pathol Lab Med 110 107–111
HT Yamase RS Wurzel PT Hieh et al. (1985) ArticleTitleImmunohistochemical demonstration of human chorionic gonadotropin in tumors of the urinary bladder Ann Clin Lab Sci 15 414–417
S Dirnhofer P Koessler C Ensinger et al. (1998) ArticleTitleProduction of trophoblastic hormones by transitional cell carcinoma of the bladder: association to tumor stage and grade Hum Pathol 29 377–382 Occurrence Handle10.1016/S0046-8177(98)90119-8 Occurrence Handle1:CAS:528:DyaK1cXivVCjs78%3D Occurrence Handle9563788
RK Iles SA Butler (1998) ArticleTitleHuman urothelial carcinomas–a-typical disease of the aged: the clinical utility of human chorionic gonadotrophin in patient management and future therapy Exp Gerontol 33 379–391
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Tuna, B., Yörükoğlu, K., Mungan, U. et al. Urothelial carcinoma of the bladder with trophoblastic differentiation: A case report. Int Urol Nephrol 36, 529–531 (2004). https://doi.org/10.1007/s11255-004-0859-4
Issue Date:
DOI: https://doi.org/10.1007/s11255-004-0859-4