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Bench to bedside: new developments in our understanding of the pathophysiology of thrombosis

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Abstract

There has been a resurgent interest in the molecular and cellular mechanisms of thrombogenesis in venous thromboembolism (VTE). Improved animal models of VTE, combined with high-resolution microscopy techniques, have helped to uncover novel roles for blood cells including platelets and innate immune cells, particularly neutrophils. These insights are likely to result in novel disease biomarkers and perhaps even adjunctive anti-thrombotic therapies.

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Acknowledgment

The author acknowledges support from NIH grant HL095096.

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Authors and Affiliations

  1. Departments of Medicine and Pathology and Laboratory Medicine, University of North Carolina, 303 Mary Ellen Jones Building, CB #7035, Chapel Hill, NC, 27599, USA

    Nigel S. Key

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  1. Nigel S. Key
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Correspondence to Nigel S. Key.

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Key, N.S. Bench to bedside: new developments in our understanding of the pathophysiology of thrombosis. J Thromb Thrombolysis 35, 342–345 (2013). https://doi.org/10.1007/s11239-013-0898-8

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  • DOI: https://doi.org/10.1007/s11239-013-0898-8

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