Skip to main content
Log in

Managing anticoagulant related coagulopathy

  • Published:
Journal of Thrombosis and Thrombolysis Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Flaherty ML, Kissela B, Woo D et al (2007) The increasing incidence of anticoagulant-associated intracerebral hemorrhage. Neurology 68(2):116–121

    Article  PubMed  CAS  Google Scholar 

  2. Koo S, Kucher N, Nguyen PL, Fanikos J, Marks PW, Goldhaber SZ (2004) The effect of excessive anticoagulation on mortality and morbidity in hospitalized patients with anticoagulant-related major hemorrhage. Arch Intern Med 164(14):1557–1560

    Article  PubMed  Google Scholar 

  3. Levine MN, Raskob G, Beyth RJ, Kearon C, Schulman S (2004) Hemorrhagic complications of anticoagulant treatment: the seventh ACCP conference on antithrombotic and thrombolytic therapy. Chest 126(3 Suppl):287S–310S

    Article  PubMed  CAS  Google Scholar 

  4. Hylek EM, Heiman H, Skates SJ, Sheehan MA, Singer DE (1998) Acetaminophen and other risk factors for excessive warfarin anticoagulation. Jama 279(9):657–662

    Article  PubMed  CAS  Google Scholar 

  5. Hart RG, Pearce LA, Aguilar MI (2007) Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med 146(12):857–867

    PubMed  Google Scholar 

  6. Beyth RJ, Quinn LM, Landefeld CS (1998) Prospective evaluation of an index for predicting the risk of major bleeding in outpatients treated with warfarin. Am J Med 105(2):91–99

    Article  PubMed  CAS  Google Scholar 

  7. Gage BF, Yan Y, Milligan PE et al (2006) Clinical classification schemes for predicting hemorrhage: results from the national registry of atrial fibrillation (NRAF). Am Heart J 151(3):713–719

    Article  PubMed  Google Scholar 

  8. Hylek EM, Chang YC, Skates SJ, Hughes RA, Singer DE (2000) Prospective study of the outcomes of ambulatory patients with excessive warfarin anticoagulation. Arch Intern Med 160(11):1612–1617

    Article  PubMed  CAS  Google Scholar 

  9. Kearon C, Ginsberg JS, Kovacs MJ et al (2003) Comparison of low-intensity warfarin therapy with conventional-intensity warfarin therapy for long-term prevention of recurrent venous thromboembolism. N Engl J Med 349(7):631–639

    Article  PubMed  CAS  Google Scholar 

  10. Ridker PM, Goldhaber SZ, Danielson E et al (2003) Long-term, low-intensity warfarin therapy for the prevention of recurrent venous thromboembolism. N Engl J Med 348(15):1425–1434

    Article  PubMed  CAS  Google Scholar 

  11. Kearon C (2004) Long-term management of patients after venous thromboembolism. Circulation 110(9 Suppl 1):I10–18

    Article  PubMed  CAS  Google Scholar 

  12. DeLoughery TG (2005) Venous thromboembolism in the ICU and reversal of bleeding on anticoagulants. Crit Care Clin 21(3):497–512

    Article  PubMed  Google Scholar 

  13. Grand’Maison ACA, Geerts WH (2005) Anticoagulant use in patients with chronic renal impairment. Am J Cardiovasc Drugs 5(5):291–305

    Article  PubMed  CAS  Google Scholar 

  14. Thorevska N, Amoateng-Adjepong Y, Sabahi R et al (2004) Anticoagulation in hospitalized patients with renal insufficiency: a comparison of bleeding rates with unfractionated heparin vs enoxaparin. Chest 125(3):856–863

    Article  PubMed  CAS  Google Scholar 

  15. Aguilar MI, Hart RG, Kase CS et al (2007) Treatment of warfarin-associated intracerebral hemorrhage: literature review and expert opinion. Mayo Clin Proc 82(1):82–92

    Article  PubMed  CAS  Google Scholar 

  16. Mayer SA, Brun NC, Begtrup K et al (2005) Recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med 352(8):777–785

    Article  PubMed  CAS  Google Scholar 

  17. Dager WE, King JH, Regalia RC et al (2006) Reversal of elevated international normalized ratios and bleeding with low-dose recombinant activated factor VII in patients receiving warfarin. Pharmacotherapy 26(8):1091–1098

    Article  PubMed  CAS  Google Scholar 

  18. Lisman T, De Groot PG (2003) Mechanism of action of recombinant factor VIIa. J Thromb Haemost 1(6):1138–1139

    Article  PubMed  CAS  Google Scholar 

  19. Ansell J, Hirsh J, Poller L, Bussey H, Jacobson A, Hylek E (2004) The pharmacology and management of the vitamin K antagonists: the seventh ACCP conference on antithrombotic and thrombolytic therapy. Chest 126(3 Suppl):204S–233S

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Amir K. Jaffer.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jaffer, A.K. Managing anticoagulant related coagulopathy. J Thromb Thrombolysis 25, 85–90 (2008). https://doi.org/10.1007/s11239-007-0107-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11239-007-0107-8

Keywords

Navigation